Making synaptic plasticity and memory last: mechanisms of translational regulation.
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Calpain 2 activated through N-methyl-D-aspartic acid receptor signaling cleaves CPEB3 and abrogates CPEB3-repressed translation in neuronsNMDAR signaling facilitates the IPO5-mediated nuclear import of CPEB3A novel role of CPEB3 in regulating EGFR gene transcription via association with Stat5b in neuronsSuppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibitionFMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autismmTOR signaling: at the crossroads of plasticity, memory and diseaseSpecification of neuronal polarity regulated by local translation of CRMP2 and Tau via the mTOR-p70S6K pathwaySingle-Nucleotide Mutations in FMR1 Reveal Novel Functions and Regulatory Mechanisms of the Fragile X Syndrome Protein FMRPEukaryotic elongation factor 2 kinase as a drug target in cancer, and in cardiovascular and neurodegenerative diseasesSex steroid hormones matter for learning and memory: estrogenic regulation of hippocampal function in male and female rodentsThe function of RNA-binding proteins at the synapse: implications for neurodegenerationDendritic spine dysgenesis in autism related disordersThe FMRP regulon: from targets to disease convergenceExtensive fusion of mitochondria in spinal cord motor neuronsContribution of Orb2A stability in regulated amyloid-like oligomerization of Drosophila Orb2Pumilio-2 function in the mouse nervous systemCPEB3 Deficiency Elevates TRPV1 Expression in Dorsal Root Ganglia Neurons to Potentiate ThermosensationLate Arc/Arg3.1 expression in the basolateral amygdala is essential for persistence of newly-acquired and reactivated contextual fear memories.Synaptic Plasticity and Neurological Disorders in Neurotropic Viral InfectionsDegradation of high affinity HuD targets releases Kv1.1 mRNA from miR-129 repression by mTORC1Requirement of Mammalian target of rapamycin complex 1 downstream effectors in cued fear memory reconsolidation and its persistence.Translational control of nociception via 4E-binding protein 1Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesiaCYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic spine formationNOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure.RNA processing and its regulation: global insights into biological networksTranslational control by eIF2α kinases in long-lasting synaptic plasticity and long-term memory.Impaired social interactions and motor learning skills in tuberous sclerosis complex model mice expressing a dominant/negative form of tuberinBrain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility.Potential therapeutic interventions for fragile X syndromeSelective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage.dFMRP and Caprin, translational regulators of synaptic plasticity, control the cell cycle at the Drosophila mid-blastula transitionInhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidationAlzheimer brain-derived amyloid β-protein impairs synaptic remodeling and memory consolidation.Mammalian target of rapamycin complex 1 activation negatively regulates Polo-like kinase 2-mediated homeostatic compensation following neonatal seizures.Gender differences in a Drosophila transcriptomic model of chronic pentylenetetrazole induced behavioral deficit.Activation of extracellular regulated kinase and mechanistic target of rapamycin pathway in focal cortical dysplasia.Understanding neuronal connectivity through the post-transcriptional toolkit.Wortmannin Attenuates Seizure-Induced Hyperactive PI3K/Akt/mTOR Signaling, Impaired Memory, and Spine Dysmorphology in RatsThe Neuronal Splicing Factor Nova Co-Localizes with Target RNAs in the Dendrite.
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Making synaptic plasticity and memory last: mechanisms of translational regulation.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Making synaptic plasticity and memory last: mechanisms of translational regulation.
@en
Making synaptic plasticity and memory last: mechanisms of translational regulation.
@nl
type
label
Making synaptic plasticity and memory last: mechanisms of translational regulation.
@en
Making synaptic plasticity and memory last: mechanisms of translational regulation.
@nl
prefLabel
Making synaptic plasticity and memory last: mechanisms of translational regulation.
@en
Making synaptic plasticity and memory last: mechanisms of translational regulation.
@nl
P356
P1433
P1476
Making synaptic plasticity and memory last: mechanisms of translational regulation.
@en
P2093
Eric Klann
Joel D Richter
P356
10.1101/GAD.1735809
P577
2009-01-01T00:00:00Z