Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell.
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Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formationChronic treatment with carvedilol improves ventricular function and reduces myocyte apoptosis in an animal model of heart failureCardiac Troponin and Tropomyosin: Structural and Cellular Perspectives to Unveil the Hypertrophic Cardiomyopathy PhenotypeSubcellular characteristics of functional intracellular renin-angiotensin systems.Identification and characterization of a functional mitochondrial angiotensin system.Telomere shortening is an in vivo marker of myocyte replication and aging.Expression of angiotensin AT(1) and AT(2) receptors in adult rat cardiomyocytes after myocardial infarction. A single-cell reverse transcriptase-polymerase chain reaction studyGlucose uptake and glycolysis reduce hypoxia-induced apoptosis in cultured neonatal rat cardiac myocytes.Progressive left ventricular remodeling and apoptosis late after myocardial infarction in mouse heart.Evidence of apoptosis in right ventricular dysfunction in rheumatic mitral valve stenosis.Postmitochondrial regulation of apoptosis during heart failurep53 Modulates the Fate of Cardiac Progenitor Cells Ex Vivo and in the Diabetic Heart In Vivo.Stretch-activated channel Piezo1 is up-regulated in failure heart and cardiomyocyte stimulated by AngII.Hypoxia-activated apoptosis of cardiac myocytes requires reoxygenation or a pH shift and is independent of p53.Tailored therapy to hemodynamic goals for advanced heart failure.Olmesartan prevents cardiac rupture in mice with myocardial infarction by modulating growth differentiation factor 15 and p53A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis.Lysine methyltransferase Smyd2 suppresses p53-dependent cardiomyocyte apoptosis.Hypoxia, angiotensin-II, and norepinephrine mediated apoptosis is stimulus specific in canine failed cardiomyocytes: a role for p38 MAPK, Fas-L and cyclin D1.Glutaredoxin-1 overexpression enhances neovascularization and diminishes ventricular remodeling in chronic myocardial infarction.Apoptosis and changes in contractile protein pattern in the skeletal muscle in heart failure.Intestinal intraepithelial lymphocyte derived angiotensin converting enzyme modulates epithelial cell apoptosis.The effects of apoptosis vulnerability markers on the myocardium in depression after myocardial infarction.Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling.Intervertebral disc degeneration: the role of the mitochondrial pathway in annulus fibrosus cell apoptosis induced by overload.Targeting signaling pathways in heart failure by gene transfer.Cystic medial degeneration of the aorta is associated with p53 accumulation, Bax upregulation, apoptotic cell death, and cell proliferation.Corneal endothelial autocrine trophic factor VIP in a mechanism-based strategy to enhance human donor cornea preservation for transplantation.Insulin-like growth factor-1 induces Mdm2 and down-regulates p53, attenuating the myocyte renin-angiotensin system and stretch-mediated apoptosis.Aldosterone and cardiovascular remodelling: focus on myocardial failure.Up-regulation of AT(1) and AT(2) receptors in postinfarcted hypertrophied myocytes and stretch-mediated apoptotic cell death.Insulin-like growth factor-1 receptor identifies a pool of human cardiac stem cells with superior therapeutic potential for myocardial regeneration.Inhibition of p53 function prevents renin-angiotensin system activation and stretch-mediated myocyte apoptosisAngiotensinII preconditioning promotes angiogenesis in vitro via ERKs phosphorylationIn situ ligation simplified: using PCR fragments for detection of double-strand DNA breaks in tissue sections.Nox4 oxidase overexpression specifically decreases endogenous Nox4 mRNA and inhibits angiotensin II-induced adventitial myofibroblast migration.Angiotensin II plays a critical role in alcohol-induced cardiac nitrative damage, cell death, remodeling, and cardiomyopathy in a protein kinase C/nicotinamide adenine dinucleotide phosphate oxidase-dependent mannerA synopsis of research in cardiac apoptosis and its application to congestive heart failureCardiac stem cells and mechanisms of myocardial regeneration.Targeting the renin-angiotensin-aldosterone-system in atrial fibrillation: a shift from electrical to structural therapy?
P2860
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P2860
Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 1998
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Stretch-mediated release of an ...... Bax protein ratio in the cell.
@en
Stretch-mediated release of an ...... Bax protein ratio in the cell.
@nl
type
label
Stretch-mediated release of an ...... Bax protein ratio in the cell.
@en
Stretch-mediated release of an ...... Bax protein ratio in the cell.
@nl
prefLabel
Stretch-mediated release of an ...... Bax protein ratio in the cell.
@en
Stretch-mediated release of an ...... Bax protein ratio in the cell.
@nl
P2093
P2860
P356
P1476
Stretch-mediated release of an ...... Bax protein ratio in the cell.
@en
P2093
A Malhotra
J Kajstura
P P Claudio
P2860
P304
P356
10.1172/JCI316
P407
P577
1998-04-01T00:00:00Z