N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands
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Modulation of adenosine receptor affinity and intrinsic efficacy in adenine nucleosides substituted at the 2-position.Structural determinants of efficacy at A3 adenosine receptors: modification of the ribose moiety.2-Dialkynyl derivatives of (N)-methanocarba nucleosides: 'Clickable' A(3) adenosine receptor-selective agonists.International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors--an updateRecent improvements in the development of A(2B) adenosine receptor agonists.A neoceptor approach to unraveling microscopic interactions between the human A2A adenosine receptor and its agonists.Probing the binding site of the A1 adenosine receptor reengineered for orthogonal recognition by tailored nucleosides.Adenosine receptor agonists: from basic medicinal chemistry to clinical development.Role of adenosine A3 receptors on CA1 hippocampal neurotransmission during oxygen-glucose deprivation episodes of different duration.Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor.2-Substituted adenosine derivatives: affinity and efficacy at four subtypes of human adenosine receptors.Medicinal chemistry of the A3 adenosine receptor: agonists, antagonists, and receptor engineering.Disparity in FcεRI-induced degranulation of primary human lung and skin mast cells exposed to adenosine.(N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists."Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonistsChapter 13. A3 Adenosine Receptors.2-triazole-substituted adenosines: a new class of selective A3 adenosine receptor agonists, partial agonists, and antagonists.Synthesis and anti-renal fibrosis activity of conformationally locked truncated 2-hexynyl-N(6)-substituted-(N)-methanocarba-nucleosides as A3 adenosine receptor antagonists and partial agonists.The A3 adenosine receptor as multifaceted therapeutic target: pharmacology, medicinal chemistry, and in silico approaches.Novel approaches for targeting the adenosine A2A receptor.A3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy.New 2,6,9-trisubstituted adenines as adenosine receptor antagonists: a preliminary SAR profile2- and 8-alkynyl-9-ethyladenines: Synthesis and biological activity at human and rat adenosine receptorsMolecular modelling study of 2-phenylethynyladenosine (PEAdo) derivatives as highly selective A₃ adenosine receptor ligands.Simulation and comparative analysis of binding modes of nucleoside and non-nucleoside agonists at the A2B adenosine receptor2-Phenylhydroxypropynyladenosine derivatives as high potent agonists at A2B adenosine receptor subtype.Functionalization of guanosine and 2'-deoxyguanosine at C6: a modified Appel process and S(N)Ar displacement of imidazole.A2B adenosine receptor agonists: synthesis and biological evaluation of 2-phenylhydroxypropynyl adenosine and NECA derivatives.2-substituted 5'-N-methylcarboxamidoadenosine (MECA) derivatives as A3 adenosine receptor ligands.
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P2860
N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands
description
2002 nî lūn-bûn
@nan
2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
N(6)-alkyl-2-alkynyl derivativ ...... nt for searching A(2B) ligands
@ast
N(6)-alkyl-2-alkynyl derivativ ...... nt for searching A(2B) ligands
@en
N(6)-alkyl-2-alkynyl derivativ ...... nt for searching A(2B) ligands
@nl
type
label
N(6)-alkyl-2-alkynyl derivativ ...... nt for searching A(2B) ligands
@ast
N(6)-alkyl-2-alkynyl derivativ ...... nt for searching A(2B) ligands
@en
N(6)-alkyl-2-alkynyl derivativ ...... nt for searching A(2B) ligands
@nl
prefLabel
N(6)-alkyl-2-alkynyl derivativ ...... nt for searching A(2B) ligands
@ast
N(6)-alkyl-2-alkynyl derivativ ...... nt for searching A(2B) ligands
@en
N(6)-alkyl-2-alkynyl derivativ ...... nt for searching A(2B) ligands
@nl
P2093
P356
P1476
N(6)-alkyl-2-alkynyl derivativ ...... nt for searching A(2B) ligands
@en
P2093
Catia Lambertucci
Gloria Cristalli
Rosaria Volpini
Sara Taffi
Sauro Vittori
P304
P356
10.1021/JM0109762
P407
P577
2002-07-01T00:00:00Z