In vivo phosphorylation of cardiac troponin I by protein kinase Cbeta2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts.
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Integration of troponin I phosphorylation with cardiac regulatory networksProtein kinase C mechanisms that contribute to cardiac remodellingRole of troponin I phosphorylation in protein kinase C-mediated enhanced contractile performance of rat myocytesASK1 associates with troponin T and induces troponin T phosphorylation and contractile dysfunction in cardiomyocytesIdentification of a functionally critical protein kinase C phosphorylation residue of cardiac troponin TPKCepsilon activation induces dichotomous cardiac phenotypes and modulates PKCepsilon-RACK interactions and RACK expressionTransgenic incorporation of skeletal TnT into cardiac myofilaments blunts PKC-mediated depression of forcePhosphorylation or glutamic acid substitution at protein kinase C sites on cardiac troponin I differentially depress myofilament tension and shortening velocityInhibition of PKC phosphorylation of cTnI improves cardiac performance in vivoIschemic dysfunction in transgenic mice expressing troponin I lacking protein kinase C phosphorylation sitesPARP-inhibitor treatment prevents hypertension induced cardiac remodeling by favorable modulation of heat shock proteins, Akt-1/GSK-3β and several PKC isoforms.PKCβII modulation of myocyte contractile performance.Brief rapid pacing depresses contractile function via Ca(2+)/PKC-dependent signaling in cat ventricular myocytes.Role of p90 ribosomal S6 kinase (p90RSK) in reactive oxygen species and protein kinase C beta (PKC-beta)-mediated cardiac troponin I phosphorylation.Dilated cardiomyopathy with increased SR Ca2+ loading preceded by a hypercontractile state and diastolic failure in the alpha(1C)TG mouse.Calcium sensitivity, force frequency relationship and cardiac troponin I: critical role of PKA and PKC phosphorylation sitesLeft ventricular and myocardial function in mice expressing constitutively pseudophosphorylated cardiac troponin I.Protein kinase C activation and its pharmacological inhibition in vascular disease.Cardiac hypertrophy and failure: lessons learned from genetically engineered mice.Coronary microvascular dysfunction in diabetes mellitus: A reviewProtein kinase C and the development of diabetic vascular complications.βIIPKC and εPKC isozymes as potential pharmacological targets in cardiac hypertrophy and heart failureGeneration and functional characterization of knock-in mice harboring the cardiac troponin I-R21C mutation associated with hypertrophic cardiomyopathy.Angiotensin II Induced Cardiac Dysfunction on a Chip.In vivo phosphorylation site mapping in mouse cardiac troponin I by high resolution top-down electron capture dissociation mass spectrometry: Ser22/23 are the only sites basally phosphorylated.Cardiac actions of protein kinase C isoformsLong-term expression of protein kinase C in adult mouse hearts improves postischemic recoveryAgonist activated PKCβII translocation and modulation of cardiac myocyte contractile function.Protein kinase C zeta. A novel regulator of both phosphorylation and de-phosphorylation of cardiac sarcomeric proteins.Protein kinase C, an elusive therapeutic target?Protein kinase C in heart failure: a therapeutic target?Multiplex kinase signaling modifies cardiac function at the level of sarcomeric proteins.Dietary supplementation with vitamin E ameliorates cardiac failure in type I diabetic cardiomyopathy by suppressing myocardial generation of 8-iso-prostaglandin F2alpha and oxidized glutathioneDesigning heart performance by gene transfer.PKCepsilon increases phosphorylation of the cardiac myosin binding protein C at serine 302 both in vitro and in vivo.Calcium signaling in cardiac myocytes.Oxidative stress and sarcomeric proteins.Erythropoietin induces positive inotropic and lusitropic effects in murine and human myocardium.PKC-ε mediates multiple endothelin-1 actions on systolic Ca2+ and contractility in ventricular myocytes.Enhanced Human-Induced Pluripotent Stem Cell Derived Cardiomyocyte Maturation Using a Dual Microgradient Substrate
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In vivo phosphorylation of cardiac troponin I by protein kinase Cbeta2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 1998
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
In vivo phosphorylation of car ...... ty in transgenic mouse hearts.
@en
In vivo phosphorylation of car ...... ty in transgenic mouse hearts.
@nl
type
label
In vivo phosphorylation of car ...... ty in transgenic mouse hearts.
@en
In vivo phosphorylation of car ...... ty in transgenic mouse hearts.
@nl
prefLabel
In vivo phosphorylation of car ...... ty in transgenic mouse hearts.
@en
In vivo phosphorylation of car ...... ty in transgenic mouse hearts.
@nl
P2093
P2860
P356
P1476
In vivo phosphorylation of car ...... ty in transgenic mouse hearts.
@en
P2093
D M Kirkpatrick
E G Kranias
H Wakasaki
Y Takeishi
P2860
P356
10.1172/JCI2709
P407
P577
1998-07-01T00:00:00Z