Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic mice.
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Modulation of cardiac contractility by the phospholamban/SERCA2a regulatomeSex hormones in the cardiovascular systemMolecular targets in heart failure gene therapy: current controversies and translational perspectivesCardiac dysfunction occurs in the HIV-1 transgenic mouse treated with zidovudineCardiac specific expression of threonine 5 to alanine mutant sarcolipin results in structural remodeling and diastolic dysfunctionCardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in miceTemporal and mutation-specific alterations in Ca2+ homeostasis differentially determine the progression of cTnT-related cardiomyopathies in murine models.Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient miceThe human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPaseIn vivo administration of urolithin A and B prevents the occurrence of cardiac dysfunction in streptozotocin-induced diabetic rats.Perioperative use of dihydropyridine calcium channel blockers.Phospholamban and cardiac contractility.Discovery and structural characterization of a phospholamban-binding cyclic peptide and design of novel inhibitors of phospholamban.Type 1 phosphatase, a negative regulator of cardiac function.Cardiac-specific overexpression of sarcolipin in phospholamban null mice impairs myocyte function that is restored by phosphorylationCarvedilol prevents ovariectomy-induced myocardial contractile dysfunction in female ratß-blocker timolol prevents arrhythmogenic Ca²⁺ release and normalizes Ca²⁺ and Zn²⁺ dyshomeostasis in hyperglycemic rat heart.Myocardial contractility is preserved early but reduced late after ovariectomy in young female rats.Postextrasystolic blood pressure potentiation predicts poor outcome of cardiac patients.Phospholamban interactome in cardiac contractility and survival: A new vision of an old friend.Targeting calcium cycling proteins in heart failure through gene transfer.Emerging therapeutic targets in chronic heart failure: part II.The cardiac response to exercise in cirrhosis.Effects of increased systolic Ca²⁺ and phospholamban phosphorylation during β-adrenergic stimulation on Ca²⁺ transient kinetics in cardiac myocytes.Sex Hormones Promote Opposite Effects on ACE and ACE2 Activity, Hypertrophy and Cardiac Contractility in Spontaneously Hypertensive Rats.Pathogenesis of dilated cardiomyopathy: molecular, structural, and population analyses in tropomodulin-overexpressing transgenic mice.A novel human R25C-phospholamban mutation is associated with super-inhibition of calcium cycling and ventricular arrhythmiaCardiac GPCRs: GPCR signaling in healthy and failing hearts.Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulationACE inhibition prevents diastolic Ca2+ overload and loss of myofilament Ca2+ sensitivity after myocardial infarction.Phospholamban overexpression in transgenic rabbitsSarcolipin and phospholamban as regulators of cardiac sarcoplasmic reticulum Ca2+ ATPase.Gene therapy in heart failure.Impaired cardiac contractility in mice lacking both the AE3 Cl-/HCO3- exchanger and the NKCC1 Na+-K+-2Cl- cotransporter: effects on Ca2+ handling and protein phosphatases.The anti-apoptotic protein HAX-1 interacts with SERCA2 and regulates its protein levels to promote cell survival.Phospholamban overexpression in rabbit ventricular myocytes does not alter sarcoplasmic reticulum Ca transportRole of PP1 in the regulation of Ca cycling in cardiac physiology and pathophysiologyA human phospholamban promoter polymorphism in dilated cardiomyopathy alters transcriptional regulation by glucocorticoids.Na/K-ATPase--an integral player in the adrenergic fight-or-flight response.In vivo phosphorylation of cardiac troponin I by protein kinase Cbeta2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts.
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P2860
Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic mice.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Cardiac-specific overexpressio ...... mechanics in transgenic mice.
@en
Cardiac-specific overexpressio ...... mechanics in transgenic mice.
@nl
type
label
Cardiac-specific overexpressio ...... mechanics in transgenic mice.
@en
Cardiac-specific overexpressio ...... mechanics in transgenic mice.
@nl
prefLabel
Cardiac-specific overexpressio ...... mechanics in transgenic mice.
@en
Cardiac-specific overexpressio ...... mechanics in transgenic mice.
@nl
P2093
P2860
P356
P1476
Cardiac-specific overexpressio ...... mechanics in transgenic mice.
@en
P2093
E G Kranias
J M Harrer
V J Kadambi
P2860
P304
P356
10.1172/JCI118446
P407
P577
1996-01-01T00:00:00Z