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Human single-stranded DNA binding proteins are essential for maintaining genomic stabilityA genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stabilityhSSB1 binds and protects p21 from ubiquitin-mediated degradation and positively correlates with p21 in human hepatocellular carcinomasDynamics of DNA damage response proteins at DNA breaks: a focus on protein modificationsIntegrator: surprisingly diverse functions in gene expressionSingle-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangsOligonucleotide/oligosaccharide-binding fold proteins: a growing family of genome guardiansSingle strand DNA binding proteins 1 and 2 protect newly replicated telomeresThe Integrator complex controls the termination of transcription at diverse classes of gene targets.Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress.The oligonucleotide/oligosaccharide-binding fold motif is a poly(ADP-ribose)-binding domain that mediates DNA damage responseHuman single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks.hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex.The tandem affinity purification technology: an overview.FBXL5-mediated degradation of single-stranded DNA-binding protein hSSB1 controls DNA damage response.A subset of Drosophila integrator proteins is essential for efficient U7 snRNA and spliceosomal snRNA 3'-end formation.The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1.Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2.Integrator complex regulates NELF-mediated RNA polymerase II pause/release and processivity at coding genes.Integrator regulates transcriptional initiation and pause release following activation.hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity.Subnuclear domain proteins in cancer cells support the functions of RUNX2 in the DNA damage response.RPA70 depletion induces hSSB1/2-INTS3 complex to initiate ATR signaling.TIMELESS Forms a Complex with PARP1 Distinct from Its Complex with TIPIN and Plays a Role in the DNA Damage ResponseReplication protein A and more: single-stranded DNA-binding proteins in eukaryotic cells.Human single-stranded DNA binding proteins: guardians of genome stability.Replication Protein A (RPA) deficiency activates the Fanconi anemia DNA repair pathway.Novel insight into the composition of human single-stranded DNA-binding protein 1 (hSSB1)-containing protein complexesThe hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivohSSB1 associates with and promotes stability of the BLM helicaseA data-driven structural model of hSSB1 (NABP2/OBFC2B) self-oligomerization.hSSB1 regulates both the stability and the transcriptional activity of p53A core hSSB1-INTS complex participates in the DNA damage responseArchaeal genome guardians give insights into eukaryotic DNA replication and damage response proteins.snRNA 3' end formation: the dawn of the Integrator complex.A structural analysis of DNA binding by hSSB1 (NABP2/OBFC2B) in solution.Pan-Cancer Mutational and Transcriptional Analysis of the Integrator Complex.Mouse models uncap novel roles of SSBs.Regulation of expression of human RNA polymerase II-transcribed snRNA geneshSSB1 (NABP2/OBFC2B) is regulated by oxidative stress
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description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 28 September 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
INTS3 controls the hSSB1-mediated DNA damage response
@en
INTS3 controls the hSSB1-mediated DNA damage response.
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type
label
INTS3 controls the hSSB1-mediated DNA damage response
@en
INTS3 controls the hSSB1-mediated DNA damage response.
@nl
prefLabel
INTS3 controls the hSSB1-mediated DNA damage response
@en
INTS3 controls the hSSB1-mediated DNA damage response.
@nl
P2093
P2860
P50
P356
P1476
INTS3 controls the hSSB1-mediated DNA damage response
@en
P2093
Alfredo Toschi
Anita Saraf
Jeffrey R Skaar
Kum Kum Khanna
P2860
P356
10.1083/JCB.200907026
P407
P577
2009-09-28T00:00:00Z