Oncogenesis caused by loss of the SNF5 tumor suppressor is dependent on activity of BRG1, the ATPase of the SWI/SNF chromatin remodeling complex. - Wikidata - awgldk - TriplyDB

Oncogenesis caused by loss of the SNF5 tumor suppressor is dependent on activity of BRG1, the ATPase of the SWI/SNF chromatin remodeling complex.

Oncogenesis caused by loss of the SNF5 tumor suppressor is dependent on activity of BRG1, the ATPase of the SWI/SNF chromatin remodeling complex.

http://www.wikidata.org/entity/Q37389731

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ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1 Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer Genetics and biology of pancreatic ductal adenocarcinoma Epithelioid Sarcoma: Opportunities for Biology-Driven Targeted Therapy SWI/SNF chromatin remodeling complexes and cancer Brg1 loss attenuates aberrant wnt-signalling and prevents wnt-dependent tumourigenesis in the murine small intestine Burrowing through the Heterogeneity: Review of Mouse Models of PTCL-NOS Synovial sarcoma: recent discoveries as a roadmap to new avenues for therapy SMARCB1-mediated SWI/SNF complex function is essential for enhancer regulation Functional redundancy of SWI/SNF catalytic subunits in maintaining vascular endothelial cells in the adult heart Generation of a mouse model of atypical teratoid/rhabdoid tumor of the central nervous system through combined deletion of Snf5 and p53.Germline nonsense mutation and somatic inactivation of SMARCA4/BRG1 in a family with rhabdoid tumor predisposition syndrome.Important role of indels in somatic mutations of human cancer genes.Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation An epigenetic chromatin remodeling role for NFATc1 in transcriptional regulation of growth and survival genes in diffuse large B-cell lymphomas.Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation.SNF5/INI1 deficiency redefines chromatin remodeling complex composition during tumor development.Modulation of extracellular matrix/adhesion molecule expression by BRG1 is associated with increased melanoma invasiveness.Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers.Rapid granulation tissue regeneration by intracellular ATP delivery--a comparison with Regranex.TCR-dependent transformation of mature memory phenotype T cells in mice.SWItching on the transcriptional circuitry in melanoma.SWI/SNF Subunits SMARCA4, SMARCD2 and DPF2 Collaborate in MLL-Rearranged Leukaemia Maintenance Rapid tissue regeneration induced by intracellular ATP delivery-A preliminary mechanistic study.Potential therapeutic targets in ARID1A-mutated cancers The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies.Swi/Snf chromatin remodeling/tumor suppressor complex establishes nucleosome occupancy at target promoters Brg1 Enables Rapid Growth of the Early Embryo by Suppressing Genes That Regulate Apoptosis and Cell Growth Arrest.CARMA: CARM1 methylation of SWI/SNF in breast cancer.Mammalian SWI/SNF Enzymes and the Epigenetics of Tumor Cell Metabolic Reprogramming.Diverse functions of ATP-dependent chromatin remodeling complexes in development and cancer.Targeting transcription factor corepressors in tumor cells.PBRM1 and BAP1 as novel targets for renal cell carcinoma A rationale to target the SWI/SNF complex for cancer therapy.Vulnerabilities of mutant SWI/SNF complexes in cancer.Essential role of BRG, the ATPase subunit of BAF chromatin remodeling complexes, in leukemia maintenance.ARID1B is a specific vulnerability in ARID1A-mutant cancers.Aberrant BAF57 signaling facilitates prometastatic phenotypes.Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway.

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Oncogenesis caused by loss of the SNF5 tumor suppressor is dependent on activity of BRG1, the ATPase of the SWI/SNF chromatin remodeling complex.

http://www.wikidata.org/entity/Q37389731

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 29 September 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Oncogenesis caused by loss of ...... chromatin remodeling complex.

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Oncogenesis caused by loss of ...... chromatin remodeling complex.

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type

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Oncogenesis caused by loss of ...... chromatin remodeling complex.

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Oncogenesis caused by loss of ...... chromatin remodeling complex.

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Oncogenesis caused by loss of ...... chromatin remodeling complex.

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Oncogenesis caused by loss of ...... chromatin remodeling complex.

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0008-5472.CAN-09-0733

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Cancer Research

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Oncogenesis caused by loss of ...... F chromatin remodeling complex

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Christopher S Thom

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Julia A Evans

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Phuong T L Nguyen

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Xi Wang

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P2860

Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits

Diversity and specialization of mammalian SWI/SNF complexes

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Cell cycle arrest and repression of cyclin D1 transcription by INI1/hSNF5.

Familial posterior fossa brain tumors of infancy secondary to germline mutation of the hSNF5 gene.

Germline mutation of INI1/SMARCB1 in familial schwannomatosis

Structure-function analysis of integrase interactor 1/hSNF5L1 reveals differential properties of two repeat motifs present in the highly conserved region

BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines

Characterization of SWI/SNF protein expression in human breast cancer cell lines and other malignancies

Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines

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8094-8101

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10.1158/0008-5472.CAN-09-0733

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20

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Courtney G Sansam

Charles W Roberts

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19789351

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2763035

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