Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation.
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The MST/Hippo Pathway and Cell Death: A Non-Canonical AffairTransactivation specificity is conserved among p53 family proteins and depends on a response element sequence codehNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencingIdentification of osteosarcoma driver genes by integrative analysis of copy number and gene expression data.The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1LATS2 suppresses oncogenic Wnt signaling by disrupting β-catenin/BCL9 interaction.A kinase shRNA screen links LATS2 and the pRB tumor suppressorp53: guardian of ploidyAberrant large tumor suppressor 2 (LATS2) gene expression correlates with EGFR mutation and survival in lung adenocarcinomas.3'UTR Shortening Potentiates MicroRNA-Based Repression of Pro-differentiation Genes in Proliferating Human Cells.The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulationThe Hippo pathway, p53 and cholesterolRegulatory module involving FGF13, miR-504, and p53 regulates ribosomal biogenesis and supports cancer cell survival.Lats2 is critical for the pluripotency and proper differentiation of stem cells.RASSF Signalling and DNA Damage: Monitoring the Integrity of the Genome?p53 and ribosome biogenesis stress: the essentials.Expression of the Argonaute protein PiwiL2 and piRNAs in adult mouse mesenchymal stem cells.Hippo pathway and protection of genome stability in response to DNA damage.LATS2 induced by TNF-alpha and inhibited cell proliferation and invasion by phosphorylating YAP in oral squamous cell carcinoma.The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway.An indirect role for ASPP1 in limiting p53-dependent p21 expression and cellular senescence.The hippo tumor suppressor network: from organ size control to stem cells and cancer.Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation.Hippo and rassf1a Pathways: A Growing AffairHippo signaling: to die or not to die.Deubiquitylase USP9X suppresses tumorigenesis by stabilizing large tumor suppressor kinase 2 (LATS2) in the Hippo pathway.p53 shades of Hippo.Expression of phosphorylated Hippo pathway kinases (MST1/2 and LATS1/2) in HER2-positive and triple-negative breast cancer patients treated with neoadjuvant therapy.Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner.
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Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 26 October 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Silencing of the Lats2 tumor s ...... as-driven cell transformation.
@en
Silencing of the Lats2 tumor s ...... as-driven cell transformation.
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type
label
Silencing of the Lats2 tumor s ...... as-driven cell transformation.
@en
Silencing of the Lats2 tumor s ...... as-driven cell transformation.
@nl
prefLabel
Silencing of the Lats2 tumor s ...... as-driven cell transformation.
@en
Silencing of the Lats2 tumor s ...... as-driven cell transformation.
@nl
P2093
P2860
P356
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Silencing of the Lats2 tumor s ...... as-driven cell transformation.
@en
P2093
H Besserglick
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P2888
P304
P356
10.1038/ONC.2009.270
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P577
2009-10-26T00:00:00Z