Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis.
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Active Stat3 is required for survival of human squamous cell carcinoma cells in serum-free conditionsLinks between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skinIdentification of a PTEN-regulated STAT3 brain tumor suppressor pathwayIdentification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cellsSTATs: An Old Story, Yet MesmerizingNucleic acid-based approaches to STAT inhibitionNormal and neoplastic urothelial stem cells: getting to the root of the problemSignal transducer and activator of transcription 3 (STAT3) protein suppresses adenoma-to-carcinoma transition in Apcmin/+ mice via regulation of Snail-1 (SNAI) protein stabilityDangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancerSTAT3 as a therapeutic target in head and neck cancerSTATs in cancer inflammation and immunity: a leading role for STAT3IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancerTranscriptional activation of the suppressor of cytokine signaling-3 (SOCS-3) gene via STAT3 is increased in F9 REX1 (ZFP-42) knockout teratocarcinoma stem cells relative to wild-type cellsEGFR-targeted therapy in malignant glioma: novel aspects and mechanisms of drug resistance.S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites.Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cellsPathway biomarker profiling of localized and metastatic human prostate cancer reveal metastatic and prognostic signaturesError-prone translesion replication of damaged DNA suppresses skin carcinogenesis by controlling inflammatory hyperplasiaProtein tyrosine phosphatases, TC-PTP, SHP1, and SHP2, cooperate in rapid dephosphorylation of Stat3 in keratinocytes following UVB irradiationStat3 regulates desmoglein 3 transcription in epithelial keratinocytes.Targeted disruption of stat3 reveals a major role for follicular stem cells in skin tumor initiation.Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activationSTAT2 contributes to promotion of colorectal and skin carcinogenesis.Targeted disruption of Bcl-xL in mouse keratinocytes inhibits both UVB- and chemically induced skin carcinogenesis.Auf1/Hnrnpd-deficient mice develop pruritic inflammatory skin disease.Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention.Biliary wound healing, ductular reactions, and IL-6/gp130 signaling in the development of liver diseaseHGF/c-met/Stat3 signaling during skin tumor cell invasion: indications for a positive feedback loop.Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?Stage-specific disruption of Stat3 demonstrates a direct requirement during both the initiation and promotion stages of mouse skin tumorigenesisEpidermal hyperproliferation in mice lacking fatty acid transport protein 4 (FATP4) involves ectopic EGF receptor and STAT3 signalingA novel mechanism of skin tumor promotion involving interferon-gamma (IFNγ)/signal transducer and activator of transcription-1 (Stat1) signaling.Constitutive Stat3 activation alters behavior of hair follicle stem and progenitor cell populationsSTAT3 activation in monocytes accelerates liver cancer progression.Stat3 mediates expression of autotaxin in breast cancerMammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesisTetramethoxychalcone, a chalcone derivative, suppresses proliferation, blocks cell cycle progression, and induces apoptosis of human ovarian cancer cells.STAT3β controls inflammatory responses and early tumor onset in skin and colon experimental cancer models.Defining a tissue stem cell-driven Runx1/Stat3 signalling axis in epithelial cancer.Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cells
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P2860
Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis.
description
article científic
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article scientifique
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articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on September 2004
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Disruption of Stat3 reveals a ...... of epithelial carcinogenesis.
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Disruption of Stat3 reveals a ...... of epithelial carcinogenesis.
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type
label
Disruption of Stat3 reveals a ...... of epithelial carcinogenesis.
@en
Disruption of Stat3 reveals a ...... of epithelial carcinogenesis.
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prefLabel
Disruption of Stat3 reveals a ...... of epithelial carcinogenesis.
@en
Disruption of Stat3 reveals a ...... of epithelial carcinogenesis.
@nl
P2093
P2860
P356
P1476
Disruption of Stat3 reveals a ...... of epithelial carcinogenesis.
@en
P2093
Joanne Anders
John DiGiovanni
Junji Takeda
Kaoru Kiguchi
Keith Syson Chan
Nobuyasu Komazawa
Shigetoshi Sano
P2860
P304
P356
10.1172/JCI200421032
P407
P577
2004-09-01T00:00:00Z