STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors. - Wikidata - awgldk - TriplyDB

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.

http://www.wikidata.org/entity/Q37502349

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Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.Radiotherapy combination opportunities leveraging immunity for the next oncology practice Oncolytic Viruses: Therapeutics With an Identity Crisis Modern Radiotherapy Concepts and the Impact of Radiation on Immune Activation Immunotherapy for cancer in the central nervous system: Current and future directions STING: infection, inflammation and cancer The Next Hurdle in Cancer Immunotherapy: Overcoming the Non-T-Cell-Inflamed Tumor Microenvironment Control of CD8 T-Cell Infiltration into Tumors by Vasculature and Microenvironment In-situ tumor vaccination: Bringing the fight to the tumor The STING pathway and the T cell-inflamed tumor microenvironment Dendritic cell-based vaccination in cancer: therapeutic implications emerging from murine models DNA sensor cGAS-mediated immune recognition The Impact of Chemotherapy, Radiation and Epigenetic Modifiers in Cancer Cell Expression of Immune Inhibitory and Stimulatory Molecules and Anti-Tumor Efficacy Immunotherapy of Malignant Tumors in the Brain: How Different from Other Sites?Molecular Pathways: Targeting the Stimulator of Interferon Genes (STING) in the Immunotherapy of Cancer Innate immune recognition of DNA: A recent history Apoptotic cell responses in the splenic marginal zone: a paradigm for immunologic reactions to apoptotic antigens with implications for autoimmunity RAD51 interconnects between DNA replication, DNA repair and immunity.Involvement of GATA1 and Sp3 in the activation of the murine STING gene promoter in NIH3T3 cells.DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity.DNA-damage-induced type I interferon promotes senescence and inhibits stem cell function.IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance Cell Free DNA of Tumor Origin Induces a 'Metastatic' Expression Profile in HT-29 Cancer Cell Line.Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING.Antibody Engineering & Therapeutics, the annual meeting of The Antibody Society December 7-10, 2015, San Diego, CA, USA.Radiation takes its Toll CD47 blockade triggers T cell-mediated destruction of immunogenic tumors.Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway CDKN1A regulates Langerhans cell survival and promotes Treg cell generation upon exposure to ionizing irradiation.SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing.The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response.STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity.Radiotherapy Combined with Novel STING-Targeting Oligonucleotides Results in Regression of Established Tumors.Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response.STING-cytosolic DNA sensing: the backbone for an effective tumor radiation therapy.PD-1 Blockade Boosts Radiofrequency Ablation-Elicited Adaptive Immune Responses against Tumor.STING Promotes the Growth of Tumors Characterized by Low Antigenicity via IDO Activation.Inflammatory Signals Regulate IL-15 in Response to Lymphodepletion.CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer.The host STING pathway at the interface of cancer and immunity

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STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.

http://www.wikidata.org/entity/Q37502349

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STING-Dependent Cytosolic DNA ...... mmunity in Immunogenic Tumors.

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STING-Dependent Cytosolic DNA ...... mmunity in Immunogenic Tumors.

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STING-Dependent Cytosolic DNA ...... mmunity in Immunogenic Tumors.

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STING-Dependent Cytosolic DNA ...... mmunity in Immunogenic Tumors.

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STING-Dependent Cytosolic DNA ...... mmunity in Immunogenic Tumors.

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STING-Dependent Cytosolic DNA ...... mmunity in Immunogenic Tumors.

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J.IMMUNI.2014.10.019

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STING-Dependent Cytosolic DNA ...... Immunity in Immunogenic Tumors

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Ainhoa Arina

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Byron Burnette

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Hua Liang

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Liufu Deng

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Meng Xu

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P2860

Activation of STAT6 by STING is critical for antiviral innate immunity

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

Pattern recognition receptors and inflammation

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

Anti-ErbB-2 mAb therapy requires type I and II interferons and synergizes with anti-PD-1 or anti-CD137 mAb therapy

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