Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled.
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The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substratesExpression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genesTranscriptional stalling in B-lymphocytes: a mechanism for antibody diversification and maintenance of genomic integrityRelated Mechanisms of Antibody Somatic Hypermutation and Class Switch RecombinationAID targeting is dependent on RNA polymerase II pausing.First AID (activation-induced cytidine deaminase) is needed to produce high affinity isotype-switched antibodiesAID targeting: old mysteries and new challengesSimultaneous in vitro characterisation of DNA deaminase function and associated DNA repair pathwaysDisruption of Transcriptional Coactivator Sub1 Leads to Genome-Wide Re-distribution of Clustered Mutations Induced by APOBEC in Active Yeast GenesNovel 9q34.11 gene deletions encompassing combinations of four Mendelian disease genes: STXBP1, SPTAN1, ENG, and TOR1A.AID and Apobec3G haphazard deamination and mutational diversityIntegrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in miceActivation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA.Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminase.Targeting of the activation-induced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA.A coming-of-age story: activation-induced cytidine deaminase turns 10.AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants.Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.AID and somatic hypermutation.A source of the single-stranded DNA substrate for activation-induced deaminase during somatic hypermutation.Negative supercoiling creates single-stranded patches of DNA that are substrates for AID-mediated mutagenesis.The cytidine deaminases AID and APOBEC-1 exhibit distinct functional properties in a novel yeast selectable system.B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil.Targeting of somatic hypermutation.The pattern of somatic hypermutation of Ig genes is altered when p53 is inactivated.Activation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complexMechanism and regulation of class switch recombinationComplex regulation and function of activation-induced cytidine deaminase.Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C biasAIDing antibody diversity by error-prone mismatch repair.Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation.Dependence of antibody gene diversification on uracil excision.Single-stranded DNA structure and positional context of the target cytidine determine the enzymatic efficiency of AID.Alkyladenine DNA glycosylase (Aag) in somatic hypermutation and class switch recombinationEvaluation of molecular models for the affinity maturation of antibodies: roles of cytosine deamination by AID and DNA repairInducible DNA breaks in Ig S regions are dependent on AID and UNGThe very 5' end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regionsIntricate targeting of immunoglobulin somatic hypermutation maximizes the efficiency of affinity maturation.Does antisense make sense of AID targeting?Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions
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Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 24 August 2004
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Activation-induced cytidine de ...... s when the DNA is supercoiled.
@en
Activation-induced cytidine deaminase
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type
label
Activation-induced cytidine de ...... s when the DNA is supercoiled.
@en
Activation-induced cytidine deaminase
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prefLabel
Activation-induced cytidine de ...... s when the DNA is supercoiled.
@en
Activation-induced cytidine deaminase
@nl
P2860
P356
P1476
Activation-induced cytidine de ...... s when the DNA is supercoiled.
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P2093
Hong Ming Shen
Ursula Storb
P2860
P304
12997-13002
P356
10.1073/PNAS.0404974101
P407
P577
2004-08-24T00:00:00Z