The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing.
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miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOTCCR4-NOT deadenylates mRNA associated with RNA-induced silencing complexes in human cellsTwo PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencingATP-dependent human RISC assembly pathwaysDeadenylation of maternal mRNAs mediated by miR-427 in Xenopus laevis embryosMicroRNAs as controlled systems and controllers in non-alcoholic fatty liver diseaseThe panorama of miRNA-mediated mechanisms in mammalian cellsStructural insights into the human GW182-PABC interaction in microRNA-mediated deadenylationTrinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endodermMutations in the GW-repeat protein SUO reveal a developmental function for microRNA-mediated translational repression in ArabidopsisPigmy MicroRNA: surveillance cops in Therapies kingdomThe mechanism of eukaryotic translation initiation and principles of its regulationIntegrative data analysis indicates an intrinsic disordered domain character of Argonaute-binding motifs.The Role of MicroRNAs in Myocardial Infarction: From Molecular Mechanism to Clinical ApplicationTRIM65 regulates microRNA activity by ubiquitination of TNRC6.Minireview: miRomics in endocrinology: a novel approach for modeling endocrine diseases.microRNAs in heart disease: putative novel therapeutic targets?The microRNA and messengerRNA profile of the RNA-induced silencing complex in human primary astrocyte and astrocytoma cellsA viral suppressor protein inhibits host RNA silencing by hooking up with Argonautes.Argonaute quenching and global changes in Dicer homeostasis caused by a pathogen-encoded GW repeat protein.Subunits of the Drosophila CCR4-NOT complex and their roles in mRNA deadenylation.Genome-wide computational identification of WG/GW Argonaute-binding proteins in Arabidopsis.NMDA mediated contextual conditioning changes miRNA expressionReceptor for activated protein kinase C: requirement for efficient microRNA function and reduced expression in hepatocellular carcinoma.Unique functionality of 22-nt miRNAs in triggering RDR6-dependent siRNA biogenesis from target transcripts in Arabidopsis.The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC.Promoter RNA links transcriptional regulation of inflammatory pathway genes.P granules extend the nuclear pore complex environment in the C. elegans germ line.Control of translation and miRNA-dependent repression by a novel poly(A) binding protein, hnRNP-Q.Divergent GW182 functional domains in the regulation of translational silencing.Limiting Ago protein restricts RNAi and microRNA biogenesis during early development in Xenopus laevis.MicroRNA machinery responds to peripheral nerve lesion in an injury-regulated pattern.Dual regulation of hepatitis C viral RNA by cellular RNAi requires partitioning of Ago2 to lipid droplets and P-bodiesMicroRNAs in systemic rheumatic diseasesRetroviral GAG proteins recruit AGO2 on viral RNAs without affecting RNA accumulation and translation.Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish.CPEB and miR-15/16 Co-Regulate Translation of Cyclin E1 mRNA during Xenopus Oocyte MaturationThe Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes.Early origin and adaptive evolution of the GW182 protein family, the key component of RNA silencing in animals.Trim65: a cofactor for regulation of the microRNA pathway
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The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 17 June 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The GW182 protein family in an ...... miRNA-mediated gene silencing.
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The GW182 protein family in an ...... miRNA-mediated gene silencing.
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type
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The GW182 protein family in an ...... miRNA-mediated gene silencing.
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The GW182 protein family in an ...... miRNA-mediated gene silencing.
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The GW182 protein family in an ...... miRNA-mediated gene silencing.
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The GW182 protein family in an ...... miRNA-mediated gene silencing.
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P2860
P356
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The GW182 protein family in an ...... miRNA-mediated gene silencing.
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P2093
Felix Tritschler
P2860
P304
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10.1261/RNA.1703809
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P577
2009-06-17T00:00:00Z