Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA.
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Mechanism for down-regulation of CD28 by Nef.Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activityBinding of c-Raf1 kinase to a conserved acidic sequence within the carboxyl-terminal region of the HIV-1 Nef proteinCo-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulationHuman immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytesPathogenesis of human immunodeficiency virus infectionThe Nef protein of HIV-1 associates with rafts and primes T cells for activationHuman immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase familyInteraction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivityThe HIV nef protein associates with protein kinase C thetaHuman immunodeficiency virus (HIV) envelope binds to CXCR4 independently of CD4, and binding can be enhanced by interaction with soluble CD4 or by HIV envelope deglycosylation.The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck.Simian immunodeficiency virus and human immunodeficiency virus type 1 nef proteins show distinct patterns and mechanisms of Src kinase activation.The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes.Physical and functional interaction of Nef with Lck. HIV-1 Nef-induced T-cell signaling defects.Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef.Human immunodeficiency virus type 1 Nef protein inhibits NF-kappa B induction in human T cells.The proteolytic cleavage of human immunodeficiency virus type 1 Nef does not correlate with its ability to stimulate virion infectivity.An arginine-faced amphipathic alpha helix is required for adenovirus type 5 e4orf6 protein functionHuman immunodeficiency virus type 2 produces a defect in CD3-gamma gene transcripts similar to that observed for human immunodeficiency virus type 1.Simian and human immunodeficiency virus Nef proteins use different surfaces to downregulate class I major histocompatibility complex antigen expression.OrfA downregulates feline immunodeficiency virus primary receptor CD134 on the host cell surface and is important in viral infection.Altered T cell activation and development in transgenic mice expressing the HIV-1 nef geneCD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration.HIV-1 Nef: a multifaceted modulator of T cell receptor signaling.Mechanism of action of regulatory proteins encoded by complex retrovirusesCharacterization of nef sequences in long-term survivors of human immunodeficiency virus type 1 infection.Human immunodeficiency virus type 1 Nef protein inhibits activation pathways in peripheral blood mononuclear cells and T-cell lines.Replication and pathogenicity of human immunodeficiency virus type 1 accessory gene mutants in SCID-hu mice.Human immunodeficiency virus type 1 Nef does not alter T-cell sensitivity to antigen-specific stimulation.The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages.Severe immunodeficiency associated with a human immunodeficiency virus 1 NEF/3'-long terminal repeat transgeneCD4 down-regulation by nef alleles isolated from human immunodeficiency virus type 1-infected individuals.HIV-1 Nef increases T cell activation in a stimulus-dependent manner.The negative effect of human immunodeficiency virus type 1 Nef on cell surface CD4 expression is not species specific and requires the cytoplasmic domain of CD4.Analysis of human immunodeficiency virus type 1 nef gene sequences present in vivo.Human immunodeficiency virus type 1 viral protein R localization in infected cells and virions.Effects of the tat and nef gene products of human immunodeficiency virus type 1 (HIV-1) on transcription controlled by the HIV-1 long terminal repeat and on cell growth in macrophagesThe human immunodeficiency virus type 1 (HIV-1) CD4 receptor and its central role in promotion of HIV-1 infection.Preferential replication of HIV-1 in the CD45RO memory cell subset of primary CD4 lymphocytes in vitro.
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Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA.
description
article científic
@ca
article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on June 1991
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Expression of the type 1 human ...... duction of interleukin 2 mRNA.
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Expression of the type 1 human ...... duction of interleukin 2 mRNA.
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type
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Expression of the type 1 human ...... duction of interleukin 2 mRNA.
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Expression of the type 1 human ...... duction of interleukin 2 mRNA.
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prefLabel
Expression of the type 1 human ...... duction of interleukin 2 mRNA.
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Expression of the type 1 human ...... duction of interleukin 2 mRNA.
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P2093
P2860
P356
P1476
Expression of the type 1 human ...... duction of interleukin 2 mRNA.
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P2093
P2860
P304
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10.1073/PNAS.88.12.5326
P407
P577
1991-06-01T00:00:00Z