The Akt kinases: isoform specificity in metabolism and cancer.
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Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein functionEmerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer developmentTherapeutic Implications of Targeting AKT Signaling in MelanomaPathophysiological basis of human papillomavirus in penile cancer: Key to prevention and delivery of more effective therapiesThe Inositide Signaling Pathway As a Target for Treating Gastric Cancer and Colorectal CancerTargeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?Caffeic Acid phenethyl ester is a potential therapeutic agent for oral cancerWhat a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathwayAkt isoforms in vascular diseaseProtein-intrinsic and signaling network-based sources of resistance to EGFR- and ErbB family-targeted therapies in head and neck cancerEmerging roles of PDGF-D in EMT progression during tumorigenesisPosttranslational regulation of Akt in human cancerInvolvement of Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-induced Incomplete Cytokinesis in the Polyploidization of Osteoclasts.Downregulation of AKT3 Increases Migration and Metastasis in Triple Negative Breast Cancer Cells by Upregulating S100A4mTOR signaling in tumorigenesisO-linked β-N-acetylglucosamine supports p38 MAPK activation by high glucose in glomerular mesangial cellsA melanoma molecular disease modelBiological Chemistry and Functionality of Protein Sulfenic Acids and Related Thiol ModificationsAll Akt isoforms (Akt1, Akt2, Akt3) are involved in normal hearing, but only Akt2 and Akt3 are involved in auditory hair cell survival in the mammalian inner ear.Disassociation of insulin action and Akt/FOXO signaling in skeletal muscle of older Akt-deficient mice.Akt3 is responsible for the survival and proliferation of embryonic stem cellsMethylthioadenosine phosphorylase and activated insulin-like growth factor-1 receptor/insulin receptor: potential therapeutic targets in chordoma.MicroRNAs are critical regulators of tuberous sclerosis complex and mTORC1 activity in the size control of the Xenopus kidney.Zeylenone, a naturally occurring cyclohexene oxide, inhibits proliferation and induces apoptosis in cervical carcinoma cells via PI3K/AKT/mTOR and MAPK/ERK pathways.Identification of a potent activator of Akt phosphorylation from a novel series of phenolic, picolinic, pyridino, and hydroxamic zinc(II) complexes.Role of RANK and Akt1 activation in human osteosarcoma progression: A clinicopathological study.Melatonin and Fertoprotective Adjuvants: Prevention against Premature Ovarian Failure during Chemotherapy.Alternative HER/PTEN/Akt pathway activation in HPV positive and negative penile carcinomasIn vitro and in vivo inhibition of neuroblastoma tumor cell growth by AKT inhibitor perifosineAkt phosphorylation and regulation of transketolase is a nodal point for amino acid control of purine synthesisAkt1 deletion prevents lung tumorigenesis by mutant K-ras.Identification of 5' AMP-activated kinase as a target of reactive aldehydes during chronic ingestion of high concentrations of ethanol.Enhanced Orai1 and STIM1 expression as well as store operated Ca2+ entry in therapy resistant ovary carcinoma cells.A novel pleckstrin homology domain-containing protein enhances insulin-stimulated Akt phosphorylation and GLUT4 translocation in adipocytes.The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membraneCaffeic acid phenethyl ester causes p21 induction, Akt signaling reduction, and growth inhibition in PC-3 human prostate cancer cells.Role of AKT signaling in DNA repair and clinical response to cancer therapy.Specific roles of Akt iso forms in apoptosis and axon growth regulation in neurons.Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasisFunctional characterization of Trip10 in cancer cell growth and survival.
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The Akt kinases: isoform specificity in metabolism and cancer.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 23 August 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The Akt kinases: isoform specificity in metabolism and cancer.
@en
The Akt kinases: isoform specificity in metabolism and cancer.
@nl
type
label
The Akt kinases: isoform specificity in metabolism and cancer.
@en
The Akt kinases: isoform specificity in metabolism and cancer.
@nl
prefLabel
The Akt kinases: isoform specificity in metabolism and cancer.
@en
The Akt kinases: isoform specificity in metabolism and cancer.
@nl
P2860
P356
P1433
P1476
The Akt kinases: isoform specificity in metabolism and cancer.
@en
P2093
Eva Gonzalez
Timothy E McGraw
P2860
P304
P356
10.4161/CC.8.16.9335
P577
2009-08-23T00:00:00Z