dSarm/Sarm1 is required for activation of an injury-induced axon death pathway
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MEK inhibitor U0126 reverses protection of axons from Wallerian degeneration independently of MEK-ERK signalingTraumatic Axonal Injury: Mechanisms and Translational OpportunitiesStem cell autotomy and niche interaction in different systemsSome reminiscences on studies of age-dependent and activity-dependent degeneration of sensory and motor endings in mammalian skeletal muscleThe Highwire ubiquitin ligase promotes axonal degeneration by tuning levels of Nmnat proteinA High-Throughput Small Molecule Screen for C. elegans Linker Cell Death InhibitorsA Nuclear Attack on Traumatic Brain Injury: Sequestration of Cell Death in the NucleusZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonatesA genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis.Death Receptor 6 Promotes Wallerian Degeneration in Peripheral Axons.A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degenerationThe Parkinsonian mimetic, 6-OHDA, impairs axonal transport in dopaminergic axons.SARM regulates CCL5 production in macrophages by promoting the recruitment of transcription factors and RNA polymerase II to the Ccl5 promoter.Three-tier regulation of cell number plasticity by neurotrophins and Tolls in Drosophila.Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neuronsDLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injuryRapid in vivo forward genetic approach for identifying axon death genes in DrosophilaAxonal transport plays a crucial role in mediating the axon-protective effects of NmNATNoncanonical cell death in the nematode Caenorhabditis elegans.Preserve and protect: maintaining axons within functional circuits.Litopenaeus vannamei sterile-alpha and armadillo motif containing protein (LvSARM) is involved in regulation of Penaeidins and antilipopolysaccharide factors.Activity-dependent degeneration of axotomized neuromuscular synapses in Wld S mice.Absence of SARM1 rescues development and survival of NMNAT2-deficient axons.Hm-MyD88 and Hm-SARM: two key regulators of the neuroimmune system and neural repair in the medicinal leechLive Imaging of Calcium Dynamics during Axon Degeneration Reveals Two Functionally Distinct Phases of Calcium Influx.Feeding the brain and nurturing the mind: Linking nutrition and the gut microbiota to brain development.SARM1 activation triggers axon degeneration locally via NAD⁺ destructionThe Apoptotic Engulfment Machinery Regulates Axonal Degeneration in C. elegans Neurons.Oxidative stress-dependent phosphorylation activates ZNRF1 to induce neuronal/axonal degenerationTransducing oxidative stress to death signals in neurons.Sculpting neural circuits by axon and dendrite pruningMild and repetitive very mild axonal stretch injury triggers cystoskeletal mislocalization and growth cone collapse.Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons.T-cell death following immune activation is mediated by mitochondria-localized SARM.SARM1, Not MyD88, Mediates TLR7/TLR9-Induced Apoptosis in Neurons.Activation of the innate signaling molecule MAVS by bunyavirus infection upregulates the adaptor protein SARM1, leading to neuronal death.Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypesHSF-1 activates the ubiquitin proteasome system to promote non-apoptotic developmental cell death in C. elegans.Excitotoxicity upregulates SARM1 protein expression and promotes Wallerian-like degeneration of retinal ganglion cells and their axons.
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dSarm/Sarm1 is required for activation of an injury-induced axon death pathway
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 07 June 2012
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
dSarm/Sarm1 is required for activation of an injury-induced axon death pathway
@en
dSarm/Sarm1 is required for activation of an injury-induced axon death pathway.
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type
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dSarm/Sarm1 is required for activation of an injury-induced axon death pathway
@en
dSarm/Sarm1 is required for activation of an injury-induced axon death pathway.
@nl
prefLabel
dSarm/Sarm1 is required for activation of an injury-induced axon death pathway
@en
dSarm/Sarm1 is required for activation of an injury-induced axon death pathway.
@nl
P2093
P2860
P356
P1433
P1476
dSarm/Sarm1 is required for activation of an injury-induced axon death pathway
@en
P2093
A Nicole Fox
Aihao Ding
Amy E Sheehan
Carl Nathan
Eric H Powell
Jeannette M Osterloh
Jennifer M MacDonald
Jennifer S Ziegenfuss
Laura Conforti
P2860
P304
P356
10.1126/SCIENCE.1223899
P407
P577
2012-06-07T00:00:00Z