Lgr4 regulates mammary gland development and stem cell activity through the pluripotency transcription factor Sox2.
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LGR4 and LGR5 Regulate Hair Cell Differentiation in the Sensory Epithelium of the Developing Mouse Cochlea.RANKL/RANK: from bone loss to the prevention of breast cancerLgr5 is a marker for fetal mammary stem cells, but is not essential for stem cell activity or tumorigenesis.Epidermal expression of Lgr6 is dependent on nerve endings and Schwann cells.A naturally occurring Lgr4 splice variant encodes a soluble antagonist useful for demonstrating the gonadal roles of Lgr4 in mammals.Lgr4 protein deficiency induces ataxia-like phenotype in mice and impairs long term depression at cerebellar parallel fiber-Purkinje cell synapsesSox2 promotes tamoxifen resistance in breast cancer cells.Profiling gene promoter occupancy of Sox2 in two phenotypically distinct breast cancer cell subsets using chromatin immunoprecipitation and genome-wide promoter microarraysAnalysis of LGR4 receptor distribution in human and mouse tissuesTargeted deletion of the murine Lgr4 gene decreases lens epithelial cell resistance to oxidative stress and induces age-related cataract formation.Simultaneous inhibition of EGFR/VEGFR and cyclooxygenase-2 targets stemness-related pathways in colorectal cancer cellsTriple negative breast cancers comprise a highly tumorigenic cell subpopulation detectable by its high responsiveness to a Sox2 regulatory region 2 (SRR2) reporterEctodysplasin/NF-κB Promotes Mammary Cell Fate via Wnt/β-catenin PathwayWnt3a: functions and implications in cancer.Establishing estrogen-responsive mouse mammary organoids from single Lgr5+ cells.Lgr4 is a key regulator of prostate development and prostate stem cell differentiation.The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strengthRSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.LGR4/GPR48 inactivation leads to aniridia-genitourinary anomalies-mental retardation syndrome defects.Emerging role for leucine-rich repeat-containing G-protein-coupled receptors LGR5 and LGR4 in cancer stem cells.Epithelial-mesenchymal transition transcription factors and miRNAs: "Plastic surgeons" of breast cancerLeucine-rich repeat-containing G protein-coupled receptor 4 facilitates vesicular stomatitis virus infection by binding vesicular stomatitis virus glycoprotein.An essential role of CBL and CBL-B ubiquitin ligases in mammary stem cell maintenance.LGR4 is required for sequential molar development.The depalmitoylase APT1 directs the asymmetric partitioning of Notch and Wnt signaling during cell division.LGR4 modulates breast cancer initiation, metastasis, and cancer stem cells.Leucine-rich repeat-containing G protein-coupled receptor 4 (Lgr4) is necessary for prostate cancer metastasis via epithelial-mesenchymal transition.Blockade of LGR4 inhibits proliferation and odonto/osteogenic differentiation of stem cells from apical papillae.LGR5 and LGR6 in stem cell biology and ovarian cancer.After genome-wide association studies: Gene networks elucidating candidate genes divergences for number of teats across two pig populations.LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption.Deciphering the roles of lncRNAs in breast development and disease.LGR6 promotes the progression of gastric cancer through PI3K/AKT/mTOR pathway.Cross-Talk between Wnt and Hh Signaling Pathways in the Pathology of Basal Cell Carcinoma.Mammary Stem Cells and Breast Cancer Stem Cells: Molecular Connections and Clinical Implications
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Lgr4 regulates mammary gland development and stem cell activity through the pluripotency transcription factor Sox2.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on September 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Lgr4 regulates mammary gland d ...... ncy transcription factor Sox2.
@en
Lgr4 regulates mammary gland d ...... ncy transcription factor Sox2.
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type
label
Lgr4 regulates mammary gland d ...... ncy transcription factor Sox2.
@en
Lgr4 regulates mammary gland d ...... ncy transcription factor Sox2.
@nl
prefLabel
Lgr4 regulates mammary gland d ...... ncy transcription factor Sox2.
@en
Lgr4 regulates mammary gland d ...... ncy transcription factor Sox2.
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P2093
P2860
P356
P1433
P1476
Lgr4 regulates mammary gland d ...... ency transcription factor Sox2
@en
P2093
P2860
P304
P356
10.1002/STEM.1438
P577
2013-09-01T00:00:00Z