The methyltransferase G9a regulates HoxA9-dependent transcription in AML.
about
Functional Role of G9a Histone Methyltransferase in CancerOpen access chemical probes for epigenetic targetsChemical probes of histone lysine methyltransferasesRole of HOXA9 in leukemia: dysregulation, cofactors and essential targetsDiscovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8Genome-wide mapping of histone H3K9me2 in acute myeloid leukemia reveals large chromosomal domains associated with massive gene silencing and sites of genome instability.Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies.G9A promotes tumor cell growth and invasion by silencing CASP1 in non-small-cell lung cancer cells.The H3K9 methyltransferase G9a is a marker of aggressive ovarian cancer that promotes peritoneal metastasis.EHMT2 inhibitor BIX-01294 induces apoptosis through PMAIP1-USP9X-MCL1 axis in human bladder cancer cellsSelective inhibitors of protein methyltransferasesH3K9 methyltransferase G9a negatively regulates UHRF1 transcription during leukemia cell differentiationFunctional Crosstalk Between Lysine Methyltransferases on Histone Substrates: The Case of G9A/GLP and Polycomb Repressive Complex 2The Histone Methyltransferase Inhibitor A-366 Uncovers a Role for G9a/GLP in the Epigenetics of Leukemia.G9a is essential for EMT-mediated metastasis and maintenance of cancer stem cell-like characters in head and neck squamous cell carcinomaThe SUV39H1 inhibitor chaetocin induces differentiation and shows synergistic cytotoxicity with other epigenetic drugs in acute myeloid leukemia cells.EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression.An LSC epigenetic signature is largely mutation independent and implicates the HOXA cluster in AML pathogenesis.MLL-AF9- and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C.Role of several histone lysine methyltransferases in tumor development.S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.G9a promotes proliferation and inhibits cell cycle exit during myogenic differentiation.Epigenetic regulation of adult stem cell function.Transcriptional Selectivity of Epigenetic Therapy in Cancer.The EMT regulator ZEB2 is a novel dependency of human and murine acute myeloid leukemia.Inhibitors of Protein Methyltransferases and Demethylases.Identification of an NKX3.1-G9a-UTY transcriptional regulatory network that controls prostate differentiation.Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenanceDiscovery of cancer drug targets by CRISPR-Cas9 screening of protein domainsTherapeutic Targeting of Epithelial Plasticity Programs: Focus on the Epithelial-Mesenchymal Transition.A drive in SUVs: From development to disease.Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.A chemical probe toolbox for dissecting the cancer epigenome.G9a histone methyltransferase inhibitor BIX01294 promotes expansion of adult cardiac progenitor cells without changing their phenotype or differentiation potential.The lysine methyltransferase Ehmt2/G9a is dispensable for skeletal muscle development and regeneration.Pharmacologic Targeting of Chromatin Modulators As Therapeutics of Acute Myeloid LeukemiaDiscovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.TWIST1-WDR5-Hottip Regulates Hoxa9 Chromatin to Facilitate Prostate Cancer Metastasis.SATB2 suppresses non-small cell lung cancer invasiveness by G9a.Structure-activity relationship studies of G9a-like protein (GLP) inhibitors.
P2860
Q26781247-8568D0E5-79AF-4464-B847-53C7C8813520Q26781872-50E7BE0D-7DCE-4A13-9265-1F10DA9135EDQ26829218-5CEE267B-CF5E-45E3-82C9-EE80B16FF7FCQ28082027-F21F76D3-4417-433A-BDD6-58E4750A3924Q28244062-CC38A90A-A07A-4569-98D1-531AAC927C18Q30252934-8E49AE04-711A-4DEC-920B-2BAC10D6E8DEQ33762936-985AF427-692D-456C-8040-294BDD861BA7Q33815948-848135D1-5282-4368-A7D6-5152333EC05BQ34662610-13B71D3E-1EDF-4A7B-A8A4-DBF638D34D26Q35079329-0452ABF2-6BD7-4346-B303-B5CB43613D3EQ35135783-A2DC2E15-1B15-433F-A678-01CA54B44F2FQ35476312-5D37FDBE-524D-4162-B477-D1E519658132Q35609473-FA8C94F0-C6EF-4232-BB56-AF5ACD7E48DCQ35683272-EDD02249-639F-44CB-9B03-65A11AFA0C1BQ35740098-3E738B0C-63F3-4296-94AA-29120DE93BBDQ35764577-7B570FCD-D7BA-4B0A-AB5F-52D071D11FB9Q36169265-6D49518E-9339-48FA-BAEA-2E8F9A20941FQ36250104-54609763-A32D-4518-AE8C-1BFA7E63801EQ36618536-6A31CF28-45B3-4B84-9F99-EDEB617AB18CQ36639797-BA1F4DCA-10F6-4913-AD44-3B53EFAC7511Q36978128-242E390E-3CAA-4E92-B03A-57BA77044A09Q37294785-D24F8EBD-CB11-4069-9F59-E944922A8418Q38233726-89F01A0E-5CC6-4636-BBFA-0C8DF14B3D33Q38729313-18A9D1CB-D625-4948-905D-9C985BF901EBQ38739798-244404DA-446B-4518-9427-E643A301A4F6Q38740496-A95A48AC-FB33-45E3-809F-5DC4E6BD979AQ38762535-0A7816B1-9637-43D4-90AD-F09654B11291Q38813967-47291E0E-852D-4470-B25F-FA847BA419AEQ38876767-860CD994-022C-475A-9CDC-F68D2D142A6AQ38953751-B2D4317C-3376-4900-A505-BBFEB44D899DQ39096411-E7B4603C-B8D4-41ED-9FA1-A0DD60E1E395Q39138373-C2D1C304-07B1-4D02-B3AE-D07B897498EDQ39147132-380AC0C6-77B3-498A-BE20-C6A03B877050Q39826187-8BB40837-3D7E-4AB6-AD8B-BDB0C47091C8Q42030522-25D345D3-CF92-4DC8-A276-D43E108F023DQ42694670-05ED92B6-56F2-4978-BD7B-82E2C79073CFQ48298211-5233AAF6-8857-4E26-B411-B0F95544A9C3Q50438849-6885ED44-A323-44A3-8CC6-5B13204F5654Q50913618-E1E531C6-432B-43EB-B579-FADE3EB4F9E2Q50916244-CB568567-8E5A-4D51-BFFE-BA49F035AC5F
P2860
The methyltransferase G9a regulates HoxA9-dependent transcription in AML.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 2014
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The methyltransferase G9a regulates HoxA9-dependent transcription in AML.
@en
The methyltransferase G9a regulates HoxA9-dependent transcription in AML.
@nl
type
label
The methyltransferase G9a regulates HoxA9-dependent transcription in AML.
@en
The methyltransferase G9a regulates HoxA9-dependent transcription in AML.
@nl
prefLabel
The methyltransferase G9a regulates HoxA9-dependent transcription in AML.
@en
The methyltransferase G9a regulates HoxA9-dependent transcription in AML.
@nl
P2093
P2860
P50
P356
P1433
P1476
The methyltransferase G9a regulates HoxA9-dependent transcription in AML.
@en
P2093
Caroline Pabst
Guy Sauvageau
Jana Krosl
Jeanette Kirschner
Josée Hébert
Michelle Miller
P2860
P304
P356
10.1101/GAD.236794.113
P577
2014-02-01T00:00:00Z