A transformation-defective mutant of Abelson murine leukemia virus lacks protein kinase activity
about
Hormone-conditional transformation by fusion proteins of c-Abl and its transforming variantsEn bloc substitution of the Src homology region 2 domain activates the transforming potential of the c-Abl protein tyrosine kinase.Abelson murine leukemia virus variants with increased oncogenic potential.Chronic myelogenous leukemia--recent advances in treatment and pathogenesis.Isolation of temperature-sensitive Abelson virus mutants by site-directed mutagenesisModeling Philadelphia chromosome positive leukemias.Breakpoints on chromosomes 9 and 22 in Philadelphia chromosome-positive chronic myelogenous leukemia (CML). Amplification of rearranged c-abl oncogenes in CML blast crisis.STI571 as a targeted therapy for CML.Mutants of Fujinami sarcoma virus which are temperature sensitive for cellular transformation and protein kinase activity.Genome structure of Abelson murine leukemia virus variants: proviruses in fibroblasts and lymphoid cellsSnyder-Theilen feline sarcoma virus P85 contains a single phosphotyrosine acceptor site recognized by its associated protein kinase.Transformation-defective mutants of Snyder-Theilen feline sarcoma virus lack tyrosine-specific protein kinase activity.Phosphorylation of the Abelson murine leukemia virus transforming protein.Evidence that the Abelson virus protein functions in vivo as a protein kinase that phosphorylates tyrosineRapid thymomas induced by Abelson murine leukemia virus.Insertional mutagenesis of the Abelson murine leukemia virus genome: identification of mutants with altered kinase activity and defective transformation ability.Synthetic peptide fragment of src gene product inhibits the src protein kinase and crossreacts immunologically with avian onc kinases and cellular phosphoproteins.Temperature-sensitive mutants of Abelson murine leukemia virus deficient in protein tyrosine kinase activity.Conservation of function of Drosophila melanogaster abl and murine v-abl proteins in transformation of mammalian cells.Carboxyl-terminal determinants of Abelson protein important for lymphoma induction.Monoclonal antibodies specific for v-abl- and c-abl-encoded molecules.Activation of the c-abl oncogene by viral transduction or chromosomal translocation generates altered c-abl proteins with similar in vitro kinase propertiesNucleic acid sequence and oncogenic properties of the HZ2 feline sarcoma virus v-abl insert.Only site-directed antibodies reactive with the highly conserved src-homologous region of the v-abl protein neutralize kinase activity.The minimum transforming region of v-abl is the segment encoding protein-tyrosine kinase.Protein stabilization explains the gag requirement for transformation of lymphoid cells by Abelson murine leukemia virusDifferent genes control the susceptibility of mice to Moloney or Abelson murine leukemia viruses.Phosphotyrosine antibodies identify the p210c-abl tyrosine kinase and proteins phosphorylated on tyrosine in human chronic myelogenous leukemia cellsA membrane-associated, carbohydrate-modified form of the v-abl protein that cannot be phosphorylated in vivo or in vitroNormal cellular and transformation-associated abl proteins share common sites for protein kinase C phosphorylation.Abelson murine leukemia virus P120: identification and characterization of tyrosine phosphorylation sites.Site-directed deletions of Abelson murine leukemia virus define 3' sequences essential for transformation and lethality.Cloning and analysis of reverse transcript P160 genomes of Abelson murine leukemia virusLocalization of the Abelson murine leukemia virus protein in a detergent-insoluble subcellular matrix: architecture of the protein.Abelson virus-infected cells can exhibit restricted in vitro growth and low oncogenic potentialGene products of McDonough feline sarcoma virus have an in vitro-associated protein kinase that phosphorylates tyrosine residues: lack of detection of this enzymatic activity in vivo.Some lymphoid cell lines transformed by Abelson murine leukemia virus lack a major 36,000-dalton tyrosine protein kinase substrateFour different classes of retroviruses induce phosphorylation of tyrosines present in similar cellular proteins.Characterization of mouse cellular deoxyribonucleic acid homologous to Abelson murine leukemia virus-specific sequences.Characterization and use of monoclonal antibodies for isolation of phosphotyrosyl proteins from retrovirus-transformed cells and growth factor-stimulated cells
P2860
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P2860
A transformation-defective mutant of Abelson murine leukemia virus lacks protein kinase activity
description
1980 nî lūn-bûn
@nan
1980年の論文
@ja
1980年学术文章
@wuu
1980年学术文章
@zh-cn
1980年学术文章
@zh-hans
1980年学术文章
@zh-my
1980年学术文章
@zh-sg
1980年學術文章
@yue
1980年學術文章
@zh
1980年學術文章
@zh-hant
name
A transformation-defective mut ...... lacks protein kinase activity
@ast
A transformation-defective mut ...... lacks protein kinase activity
@en
type
label
A transformation-defective mut ...... lacks protein kinase activity
@ast
A transformation-defective mut ...... lacks protein kinase activity
@en
prefLabel
A transformation-defective mut ...... lacks protein kinase activity
@ast
A transformation-defective mut ...... lacks protein kinase activity
@en
P2093
P2860
P356
P1476
A transformation-defective mut ...... lacks protein kinase activity
@en
P2093
P2860
P304
P356
10.1073/PNAS.77.8.4993
P407
P577
1980-08-01T00:00:00Z