The role of parkin in familial and sporadic Parkinson's disease.
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PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's diseasePhosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective functionParkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cellsAutoregulation of Parkin activity through its ubiquitin-like domainATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkinStructure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of NeuroprotectionMechanisms of mitophagyParkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's diseaseMechanism and disease association of E2-conjugating enzymes: lessons from UBE2T and UBE2L3The parkin-like human homolog of Drosophila ariadne-1 (HHARI) can induce aggresome formation in mammalian cells and is immunologically detectable in Lewy bodiesSTEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson's diseaseGene-environment interactions: key to unraveling the mystery of Parkinson's diseaseParkin promotes degradation of the mitochondrial pro-apoptotic ARTS proteinLandscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarizationLabel free fragment screening using surface plasmon resonance as a tool for fragment finding - analyzing parkin, a difficult CNS targetQuantitative proteomic analysis of Parkin substrates in Drosophila neurons.Loss of Parkin reduces inflammatory arthritis by inhibiting p53 degradationVPS35, the Retromer Complex and Parkinson's Disease.Parkin-mediated ubiquitination of mutant glucocerebrosidase leads to competition with its substrates PARIS and ARTSParkin regulates translesion DNA synthesis in response to UV radiationα-Synuclein expression selectively affects tumorigenesis in mice modeling Parkinson's disease.PINK1 triggers autocatalytic activation of Parkin to specify cell fate decisionsCopy number deletion has little impact on gene expression levels in racehorses.Recent advances in the genetics of Parkinson's disease.Small, N-terminal tags activate Parkin E3 ubiquitin ligase activity by disrupting its autoinhibited conformation.Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.Parkin-mediated K63-polyubiquitination targets ubiquitin C-terminal hydrolase L1 for degradation by the autophagy-lysosome system.Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in α-synuclein transgenic mice.Upregulation of Parkin in endophilin mutant mice.Molecular insights into Parkinson's disease.Ubiquitination increases parkin activity to promote autophagic α-synuclein clearance.Parkin loss of function contributes to RTP801 elevation and neurodegeneration in Parkinson's disease.PARK2 variability in Polish Parkinson's disease patients--interaction with mitochondrial haplogroups.Drosophila as a model to study mitochondrial dysfunction in Parkinson's disease.Molecular events underlying Parkinson's disease - an interwoven tapestry.Genomic mechanisms underlying PARK2 large deletions identified in a cohort of patients with PD.Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice.Involvement of inhibitory PAS domain protein in neuronal cell death in Parkinson's disease.AF-6 is a positive modulator of the PINK1/parkin pathway and is deficient in Parkinson's disease.Genetic animal models of Parkinson's disease.
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The role of parkin in familial and sporadic Parkinson's disease.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
The role of parkin in familial and sporadic Parkinson's disease.
@en
The role of parkin in familial and sporadic Parkinson's disease.
@nl
type
label
The role of parkin in familial and sporadic Parkinson's disease.
@en
The role of parkin in familial and sporadic Parkinson's disease.
@nl
prefLabel
The role of parkin in familial and sporadic Parkinson's disease.
@en
The role of parkin in familial and sporadic Parkinson's disease.
@nl
P2860
P356
P1433
P1476
The role of parkin in familial and sporadic Parkinson's disease.
@en
P2093
Valina L Dawson
P2860
P356
10.1002/MDS.22798
P407
P478
25 Suppl 1
P577
2010-01-01T00:00:00Z