Fragile X mental retardation protein is necessary for neurotransmitter-activated protein translation at synapses - Wikidata - awgldk - TriplyDB

Fragile X mental retardation protein is necessary for neurotransmitter-activated protein translation at synapses

Fragile X mental retardation protein is necessary for neurotransmitter-activated protein translation at synapses

http://www.wikidata.org/entity/Q37713828

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Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function Advances in the treatment of fragile X syndrome A pilot open label, single dose trial of fenobam in adults with fragile X syndrome.Dendritic mRNAs encode diversified functionalities in hippocampal pyramidal neurons Dysregulation and restoration of translational homeostasis in fragile X syndrome Fragile X syndrome and targeted treatment trials.Learning and behavioral deficits associated with the absence of the fragile X mental retardation protein: what a fly and mouse model can teach us.Increased expression of the PI3K enhancer PIKE mediates deficits in synaptic plasticity and behavior in fragile X syndrome.Haploinsufficiency of Cyfip1 produces fragile X-like phenotypes in mice The G-quartet containing FMRP binding site in FMR1 mRNA is a potent exonic splicing enhancer From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome Genetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse model.Roles of fragile X mental retardation protein in dopaminergic stimulation-induced synapse-associated protein synthesis and subsequent alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-4-propionate (AMPA) receptor internalization Increased secreted amyloid precursor protein-α (sAPPα) in severe autism: proposal of a specific, anabolic pathway and putative biomarker FMR1 transcript isoforms: association with polyribosomes; regional and developmental expression in mouse brain The RNA binding and transport proteins staufen and fragile X mental retardation protein are expressed by rat primary afferent neurons and localize to peripheral and central axons Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD Motor-induced transcription but sensory-regulated translation of ZENK in socially interactive songbirds.Enhanced expression of ADCY1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model.From FMRP function to potential therapies for fragile X syndrome.Modeling psychiatric disorders at the cellular and network levels CGG repeat in the FMR1 gene: size matters Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice.BC1 regulation of metabotropic glutamate receptor-mediated neuronal excitability.FMRP mediates mGluR5-dependent translation of amyloid precursor protein.Identifying intrinsic and extrinsic determinants that regulate internal initiation of translation mediated by the FMR1 5' leader.Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo Fragile X targeted pharmacotherapy: lessons learned and future directions.The RNA-binding protein fragile X-related 1 regulates somite formation in Xenopus laevis.Loss of the fragile X mental retardation protein decouples metabotropic glutamate receptor dependent priming of long-term potentiation from protein synthesis.Altered differentiation of neural stem cells in fragile X syndrome RNA exodus to Israel: RNA controlling function in the far reaches of the neuron. Workshop on RNA control on neuronal function.Increasing our understanding of human cognition through the study of Fragile X Syndrome.Deficits in LTP induction by 5-HT2A receptor antagonist in a mouse model for fragile X syndrome A 3' untranslated region variant in FMR1 eliminates neuronal activity-dependent translation of FMRP by disrupting binding of the RNA-binding protein HuR Fragile X mental retardation protein expression in Alzheimer's disease Increased long-term potentiation at medial-perforant path-dentate granule cell synapses induced by selective inhibition of histone deacetylase 3 requires Fragile X mental retardation protein Genetic controls balancing excitatory and inhibitory synaptogenesis in neurodevelopmental disorder models.Fragile X mental retardation protein regulates heterosynaptic plasticity in the hippocampus Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders

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Fragile X mental retardation protein is necessary for neurotransmitter-activated protein translation at synapses

http://www.wikidata.org/entity/Q37713828

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2004 nî lūn-bûn

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2004年の論文

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年學術文章

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2004年學術文章

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2004年學術文章

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Fragile X mental retardation p ...... rotein translation at synapses

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Fragile X mental retardation p ...... otein translation at synapses.

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Fragile X mental retardation p ...... rotein translation at synapses

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Fragile X mental retardation p ...... rotein translation at synapses

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PNAS.0407533101

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Proceedings of the National Academy of Sciences of the United States of America

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Fragile X mental retardation p ...... rotein translation at synapses

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P2093

Aaron W Grossman

http://www.w3.org/2001/XMLSchema#string

Chad C Spangler

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Christine K Base

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Fatima Hatia

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Femke A E Lambers

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Froukje E de Vries

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Hooma Khaliq

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Ivan Jeanne Weiler

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Soong Ho Kim

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Valerie Bertaina-Anglade

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P2860

Altered synaptic plasticity in a mouse model of fragile X mental retardation

Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex

Metabotropic glutamate receptors trigger postsynaptic protein synthesis

Abnormal dendritic spines in fragile X knockout mice: maturation and pruning deficits

Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation

Evidence that fragile X mental retardation protein is a negative regulator of translation

The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein

Fragile X mental retardation protein: nucleocytoplasmic shuttling and association with somatodendritic ribosomes

The fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif.

Localization of translational components at the ultramicroscopic level at postsynaptic sites of the rat brain

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17504-17509

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50

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101

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Anna Y Klintsova

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2004-11-17T00:00:00Z

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8177894

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15548614

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neurotransmitter

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536018

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