Zn2+ interaction with Alzheimer amyloid beta protein calcium channels
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Curcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st centuryDeciphering the glycolipid code of Alzheimer's and Parkinson's amyloid proteins allowed the creation of a universal ganglioside-binding peptideAβ42 assembles into specific β-barrel pore-forming oligomers in membrane-mimicking environments.All-d-Enantiomer of β-Amyloid Peptide Forms Ion Channels in Lipid Bilayers.Role of endocytic inhibitory drugs on internalization of amyloidogenic light chains by cardiac fibroblasts.Models of beta-amyloid ion channels in the membrane suggest that channel formation in the bilayer is a dynamic process.Differential effects of lead and zinc on inhibitory avoidance learning in mice.Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases.Raft lipids as common components of human extracellular amyloid fibrils.Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndromeSimultaneous single-molecule fluorescence and conductivity studies reveal distinct classes of Abeta species on lipid bilayersAmyloid-beta-induced ion flux in artificial lipid bilayers and neuronal cells: resolving a controversyMolecular mechanisms of neurodegeneration in Alzheimer's disease.Antimicrobial protegrin-1 forms ion channels: molecular dynamic simulation, atomic force microscopy, and electrical conductance studiesAlzheimer's disease amyloid beta-protein forms Zn(2+)-sensitive, cation-selective channels across excised membrane patches from hypothalamic neurons.Structural convergence among diverse, toxic beta-sheet ion channels.Mechanisms of beta-amyloid neurotoxicity: perspectives of pharmacotherapy.Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs.Mechanisms for the Insertion of Toxic, Fibril-like β-Amyloid Oligomers into the Membrane.Alzheimer's disease: which type of amyloid-preventing drug agents to employ?Multivariate analyses of amyloid-beta oligomer populations indicate a connection between pore formation and cytotoxicityDietary zinc supplementation of 3xTg-AD mice increases BDNF levels and prevents cognitive deficits as well as mitochondrial dysfunctionIon channel formation and membrane-linked pathologies of misfolded hydrophobic proteins: the role of dangerous unchaperoned molecules.Membrane Incorporation, Channel Formation, and Disruption of Calcium Homeostasis by Alzheimer's β-Amyloid Protein.Small molecule blockers of the Alzheimer Abeta calcium channel potently protect neurons from Abeta cytotoxicity.The amyloid beta ion channel hypothesis of Alzheimer's disease.A glycine zipper motif mediates the formation of toxic β-amyloid oligomers in vitro and in vivo.Interaction of heat shock protein 70 with membranes depends on the lipid environment.Single-channel Ca(2+) imaging implicates Aβ1-42 amyloid pores in Alzheimer's disease pathologyAmyloid β-mediated Zn2+ influx into dentate granule cells transiently induces a short-term cognitive deficit.Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's diseaseProbing structural features of Alzheimer's amyloid-β pores in bilayers using site-specific amino acid substitutions.Antimicrobial properties of amyloid peptides.Specific Binding of Cu(II) Ions to Amyloid-Beta Peptides Bound to Aggregation-Inhibiting Molecules or SDS Micelles Creates Complexes that Generate Radical Oxygen Species.Two-step mechanism of membrane disruption by Aβ through membrane fragmentation and pore formationA central role for ROS in the functional remodelling of L-type Ca2+ channels by hypoxiaThe role of an astrocytic NADPH oxidase in the neurotoxicity of amyloid beta peptides.Neurosteroids block the increase in intracellular calcium level induced by Alzheimer’s β-amyloid protein in long-term cultured rat hippocampal neurons.Amyloid beta ion channel: 3D structure and relevance to amyloid channel paradigm.Soluble amyloid beta-oligomers affect dielectric membrane properties by bilayer insertion and domain formation: implications for cell toxicity
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P2860
Zn2+ interaction with Alzheimer amyloid beta protein calcium channels
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Zn2+ interaction with Alzheimer amyloid beta protein calcium channels
@en
Zn2+ interaction with Alzheimer amyloid beta protein calcium channels.
@nl
type
label
Zn2+ interaction with Alzheimer amyloid beta protein calcium channels
@en
Zn2+ interaction with Alzheimer amyloid beta protein calcium channels.
@nl
prefLabel
Zn2+ interaction with Alzheimer amyloid beta protein calcium channels
@en
Zn2+ interaction with Alzheimer amyloid beta protein calcium channels.
@nl
P2093
P2860
P356
P1476
Zn2+ interaction with Alzheimer amyloid beta protein calcium channels
@en
P2093
P2860
P304
P356
10.1073/PNAS.93.4.1710
P407
P577
1996-02-01T00:00:00Z