ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor identified using the JFCR39 drug discovery system.
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Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?Class I PI3K inhibitor ZSTK474 mediates a shift in microglial/macrophage phenotype and inhibits inflammatory response in mice with cerebral ischemia/reperfusion injury.Recent development of ATP-competitive small molecule phosphatidylinostitol-3-kinase inhibitors as anticancer agentsPI3K isoform inhibition associated with anti Bcr-Abl drugs shows in vitro increased anti-leukemic activity in Philadelphia chromosome-positive B-acute lymphoblastic leukemia cell linesAntiproliferative effect of ZSTK474 alone or in combination with chemotherapeutic drugs on HL60 and HL60/ADR cellsIn vitro antitumor activity of stellettin B, a triterpene from marine sponge Jaspis stellifera, on human glioblastoma cancer SF295 cells.Target identification of small molecules based on chemical biology approaches.Redox signaling via oxidative inactivation of PTEN modulates pressure-dependent myogenic tone in rat middle cerebral arteriesAntiproliferative and antiangiogenic activities of smenospongine, a marine sponge sesquiterpene aminoquinone.Neurotrophins regulate ApoER2 proteolysis through activation of the Trk signaling pathway.ZSTK474, a PI3K inhibitor, suppresses proliferation and sensitizes human pancreatic adenocarcinoma cells to gemcitabine.In Vitro Antileukemia Activity of ZSTK474 on K562 and Multidrug Resistant K562/A02 Cells.ZSTK474, a specific class I phosphatidylinositol 3-kinase inhibitor, induces G1 arrest and autophagy in human breast cancer MCF-7 cells.Class I phosphatidylinositol 3-kinase inhibitors for cancer therapy.A pharmacological model reveals biased dependency on PI3K isoforms for tumor cell growth.Inhibition of class IA PI3K enzymes in non-small cell lung cancer cells uncovers functional compensation among isoforms.In vitro multifaceted activities of a specific group of novel phosphatidylinositol 3-kinase inhibitors on hotspot mutant PIK3CA.Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G1 cyclins/cyclin-dependent kinases and the phosphoinositide 3-kinase/AKT signaling cascade.Synthesis and biological evaluation of novel 6-hydrazinyl-2,4-bismorpholino pyrimidine and 1,3,5-triazine derivatives as potential antitumor agents.In vitro antimetastatic effect of phosphatidylinositol 3-kinase inhibitor ZSTK474 on prostate cancer PC3 cells.Class III phosphoinositide 3-kinase/VPS34 and dynamin are critical for apical endocytic recycling.Synthesis and antimetastatic effects of E-salignone amide derivatives.Inhibitory effects of ZSTK474, a phosphatidylinositol 3-kinase inhibitor, on adjuvant-induced arthritis in rats.
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ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor identified using the JFCR39 drug discovery system.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 23 August 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
ZSTK474, a novel phosphatidyli ...... JFCR39 drug discovery system.
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ZSTK474, a novel phosphatidyli ...... JFCR39 drug discovery system.
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type
label
ZSTK474, a novel phosphatidyli ...... JFCR39 drug discovery system.
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ZSTK474, a novel phosphatidyli ...... JFCR39 drug discovery system.
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prefLabel
ZSTK474, a novel phosphatidyli ...... JFCR39 drug discovery system.
@en
ZSTK474, a novel phosphatidyli ...... JFCR39 drug discovery system.
@nl
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P356
P1476
ZSTK474, a novel phosphatidyli ...... JFCR39 drug discovery system.
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P2093
De-xin Kong
Takao Yamori
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P2888
P304
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10.1038/APS.2010.150
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2010-08-23T00:00:00Z