Guanine nucleotide exchange factors for RhoGTPases: good therapeutic targets for cancer therapy?
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Novel therapeutic targets for pancreatic cancerVav1: A Dr. Jekyll and Mr. Hyde protein--good for the hematopoietic system, bad for cancerApproaches of targeting Rho GTPases in cancer drug discoveryRho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and diseaseCross-species epigenetics identifies a critical role for VAV1 in SHH subgroup medulloblastoma maintenanceArhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cellsPlekhg4 is a novel Dbl family guanine nucleotide exchange factor protein for rho family GTPasesTGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion.Estrogen induces Vav1 expression in human breast cancer cells.PRL-3 engages the focal adhesion pathway in triple-negative breast cancer cells to alter actin structure and substrate adhesion properties critical for cell migration and invasionThe emerging role of guanine nucleotide exchange factors in ALS and other neurodegenerative diseases.Aberrant glycogen synthase kinase 3β is involved in pancreatic cancer cell invasion and resistance to therapy.Cidofovir selectivity is based on the different response of normal and cancer cells to DNA damage.ARAP3 functions in hematopoietic stem cellsIncreased diacylglycerol kinase ζ expression in human metastatic colon cancer cells augments Rho GTPase activity and contributes to enhanced invasion.Extracellular superoxide dismutase regulates the expression of small gtpase regulatory proteins GEFs, GAPs, and GDI.VAV3 oncogene expression in colorectal cancer: clinical aspects and functional characterization.Characterization of EHop-016, novel small molecule inhibitor of Rac GTPaseClinical significance and prognostic value of Vav1 expression in Non-small cell lung cancer.Plasma membrane restricted RhoGEF activity is sufficient for RhoA-mediated actin polymerization.The protooncogene Vav1 regulates murine leukemia virus-induced T-cell leukemogenesis.Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cellsThe N-terminal 20-amino acid region of guanine nucleotide exchange factor Vav1 plays a distinguished role in T cell receptor-mediated calcium signaling.Coevolution of RAC Small GTPases and their Regulators GEF Proteins.Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in cancer-associated fibroblasts.De-repression of the RAC activator ELMO1 in cancer stem cells drives progression of TGFβ-deficient squamous cell carcinoma from transition zones.Targeting Rho GTPase signaling for cancer therapy.Vav1 in hematologic neoplasms, a mini review.Insights into the biological functions of Dock family guanine nucleotide exchange factors.The sarcomeric M-region: a molecular command center for diverse cellular processes.Regulatory mechanisms of EGFR signalling during Drosophila eye development.Vav1 promotes lung cancer growth by instigating tumor-microenvironment cross-talk via growth factor secretion.Ras and Rho GTPases on the move: The RasGRF connection.A tumor suppressor role for srGAP3 in mammary epithelial cells.Ectopically expressed IBP promotes cell proliferation in oral squamous cell carcinoma.The role of RhoC in the proliferation and apoptosis of hepatocellular carcinoma cells.Genetic variants in the genes encoding rho GTPases and related regulators predict cutaneous melanoma-specific survival.The Salmonella Typhimurium effector SteC inhibits Cdc42-mediated signaling through binding to the exchange factor Cdc24 in Saccharomyces cerevisiae.Oncogenic Signaling by Leukemia-Associated Mutant Cbl ProteinsStructure analysis between the SWAP-70 RHO-GEF and the newly described PLD2-GEF
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Guanine nucleotide exchange factors for RhoGTPases: good therapeutic targets for cancer therapy?
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 30 October 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Guanine nucleotide exchange fa ...... ic targets for cancer therapy?
@en
Guanine nucleotide exchange fa ...... ic targets for cancer therapy?
@nl
type
label
Guanine nucleotide exchange fa ...... ic targets for cancer therapy?
@en
Guanine nucleotide exchange fa ...... ic targets for cancer therapy?
@nl
prefLabel
Guanine nucleotide exchange fa ...... ic targets for cancer therapy?
@en
Guanine nucleotide exchange fa ...... ic targets for cancer therapy?
@nl
P1433
P1476
Guanine nucleotide exchange fa ...... ic targets for cancer therapy?
@en
P2093
Galit Lazer
Shulamit Katzav
P304
P356
10.1016/J.CELLSIG.2010.10.022
P577
2010-10-30T00:00:00Z