Non-genomic loss of PTEN function in cancer: not in my genes.
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Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein functionA comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromesProtein kinases and phosphatases in the control of cell fateProtein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transductionThe non-genomic loss of function of tumor suppressors: an essential role in the pathogenesis of chronic myeloid leukemia chronic phaseThe Role of PTEN in Myeloid MalignanciesThe PTEN tumor suppressor gene and its role in lymphoma pathogenesisPhosphatase and Tensin Homologue: Novel Regulation by Developmental SignalingPI3K-AKT-mTOR-signaling and beyond: the complex network in gastroenteropancreatic neuroendocrine neoplasmsPTEN plasticity: how the taming of a lethal gene can go too farTherapeutic targeting of cancers with loss of PTEN function.A Drosophila-centric view of protein tyrosine phosphatasesHCV infection-associated hepatocellular carcinoma in humanized miceA functional dissection of PTEN N-terminus: implications in PTEN subcellular targeting and tumor suppressor activityTGFβ-stimulated microRNA-21 utilizes PTEN to orchestrate AKT/mTORC1 signaling for mesangial cell hypertrophy and matrix expansionT-REX on-demand redox targeting in live cells.The Concise Guide to PHARMACOLOGY 2013/14: enzymes.Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway.Functional analysis of the protein phosphatase activity of PTENPhosphorylation of transglutaminase 2 (TG2) at serine-216 has a role in TG2 mediated activation of nuclear factor-kappa B and in the downregulation of PTENUbiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase.PTEN: Multiple Functions in Human Malignant TumorsBCR-ABL promotes PTEN downregulation in chronic myeloid leukemia.Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells.Involvement of Akt-1 and mTOR in sensitivity of breast cancer to targeted therapyCooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells.Lapatinib and obatoclax kill tumor cells through blockade of ERBB1/3/4 and through inhibition of BCL-XL and MCL-1.The Optimization of Soluble PTEN Expression in Escherichia colimiR-21 is targeted by omega-3 polyunsaturated fatty acid to regulate breast tumor CSF-1 expression.Evaluation of AKT phosphorylation and PTEN loss and their correlation with the resistance of rituximab in DLBCL.Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent.Phosphatase and tensin homolog is a differential diagnostic marker between nonalcoholic and alcoholic fatty liver disease.Recent progress in mouse models for tumor suppressor genes and its implications in human cancer.PML/RARa inhibits PTEN expression in hematopoietic cells by competing with PU.1 transcriptional activity.Regulation of protein tyrosine phosphatases by reversible oxidation.Epigenetic and epigenomic mechanisms shape sarcoma and other mesenchymal tumor pathogenesis.The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches.Protein tyrosine phosphatase structure-function relationships in regulation and pathogenesis.The promise of mTOR inhibitors in the treatment of colorectal cancer.
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Non-genomic loss of PTEN function in cancer: not in my genes.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 13 January 2011
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Non-genomic loss of PTEN function in cancer: not in my genes.
@en
Non-genomic loss of PTEN function in cancer: not in my genes.
@nl
type
label
Non-genomic loss of PTEN function in cancer: not in my genes.
@en
Non-genomic loss of PTEN function in cancer: not in my genes.
@nl
prefLabel
Non-genomic loss of PTEN function in cancer: not in my genes.
@en
Non-genomic loss of PTEN function in cancer: not in my genes.
@nl
P1476
Non-genomic loss of PTEN function in cancer: not in my genes
@en
P2093
Michelangelo Foti
P304
P356
10.1016/J.TIPS.2010.12.005
P577
2011-01-13T00:00:00Z