PTEN level in tumor suppression: how much is too little?
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A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromesPTEN suppresses the oncogenic function of AIB1 through decreasing its protein stability via mechanism involving Fbw7 alphaProtein kinases and phosphatases in the control of cell fateWhat a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathwayPTEN plasticity: how the taming of a lethal gene can go too farWrecked regulation of intrinsically disordered proteins in diseases: pathogenicity of deregulated regulatorsTargeting the Phosphatidylinositol-3-kinase Pathway in Gastric Cancer: Can Omics Improve Outcomes?Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesisPIK3CA mutations in breast cancer: reconciling findings from preclinical and clinical dataHCV infection-associated hepatocellular carcinoma in humanized miceChronic inorganic arsenic exposure in vitro induces a cancer cell phenotype in human peripheral lung epithelial cellsMiR-130a and MiR-374a Function as Novel Regulators of Cisplatin Resistance in Human Ovarian Cancer A2780 CellsA novel PTEN/mutant p53/c-Myc/Bcl-XL axis mediates context-dependent oncogenic effects of PTEN with implications for cancer prognosis and therapyGenetic polymorphisms altering microRNA activity in psoriasis--a key to solve the puzzle of missing heritability?Direct effects of metformin in the endometrium: a hypothetical mechanism for the treatment of women with PCOS and endometrial carcinoma.TGF-β induces phosphorylation of phosphatase and tensin homolog: implications for fibrosis of the trabecular meshwork tissue in glaucomaEngineering ePTEN, an enhanced PTEN with increased tumor suppressor activities.A bistable model of cell polarity.The effect of systemic PTEN antagonist peptides on axon growth and functional recovery after spinal cord injury.Overview of the biochemical and genetic processes in malignant mesothelioma.Mechanism of human PTEN localization revealed by heterologous expression in Dictyostelium.PTEN: Multiple Functions in Human Malignant TumorsProtein tyrosine phosphatases PTP-1B, SHP-2, and PTEN facilitate Rb/E2F-associated apoptotic signaling.Loss of PTEN expression is associated with increased risk of recurrence after prostatectomy for clinically localized prostate cancerPhosphatase and tensin homolog on chromosome 10 is phosphorylated in primary effusion lymphoma and Kaposi's sarcoma.Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancerEngineering FKBP-Based Destabilizing Domains to Build Sophisticated Protein Regulation Systems.Variants on the promoter region of PTEN affect breast cancer progression and patient survival.Inactivation of tumor suppressor gene pten in early and advanced gallbladder cancerDual targeting of the Akt/mTOR signaling pathway inhibits castration-resistant prostate cancer in a genetically engineered mouse model.Keratoacanthoma of the Lip: Activation of the mTOR Pathway, Tumor Suppressor Proteins, and Tumor SenescenceMyocardial ischemic post-conditioning attenuates ischemia reperfusion injury via PTEN/Akt signal pathway.PTEN at a glance.Evaluation of AKT phosphorylation and PTEN loss and their correlation with the resistance of rituximab in DLBCL.The prognostic effect of PTEN expression status in colorectal cancer development and evaluation of factors affecting it: miR-21 and promoter methylationINPP4B is upregulated and functions as an oncogenic driver through SGK3 in a subset of melanomas.Largazole: from discovery to broad-spectrum therapy.PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanomaAchieving specificity in Akt signaling in cancer.Role of TRPM2 in cell proliferation and susceptibility to oxidative stress
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PTEN level in tumor suppression: how much is too little?
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 25 January 2011
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
PTEN level in tumor suppression: how much is too little?
@en
PTEN level in tumor suppression: how much is too little?
@nl
type
label
PTEN level in tumor suppression: how much is too little?
@en
PTEN level in tumor suppression: how much is too little?
@nl
prefLabel
PTEN level in tumor suppression: how much is too little?
@en
PTEN level in tumor suppression: how much is too little?
@nl
P2860
P1433
P1476
PTEN level in tumor suppression: how much is too little?
@en
P2093
Andrea Alimonti
Arkaitz Carracedo
P2860
P304
P356
10.1158/0008-5472.CAN-10-2488
P407
P577
2011-01-25T00:00:00Z