Increasing recognition of the importance of aldehyde oxidase in drug development and discovery.
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The First Mammalian Aldehyde Oxidase Crystal Structure: INSIGHTS INTO SUBSTRATE SPECIFICITYDiscovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug DesignOptimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide PolymorphismsThe impact of single nucleotide polymorphisms on human aldehyde oxidaseThe four aldehyde oxidases of Drosophila melanogaster have different gene expression patterns and enzyme substrate specificitiesInhibition of human liver aldehyde oxidase: implications for potential drug-drug interactions.Interspecies differences in the metabolism of methotrexate: An insight into the active site differences between human and rabbit aldehyde oxidasePredicting intrinsic clearance for drugs and drug candidates metabolized by aldehyde oxidase.Mouse aldehyde-oxidase-4 controls diurnal rhythms, fat deposition and locomotor activityAbsolute quantification of aldehyde oxidase protein in human liver using liquid chromatography-tandem mass spectrometryStrategies for a comprehensive understanding of metabolism by aldehyde oxidase.Aldehyde oxidase and its importance in novel drug discovery: present and future challenges.A mouse with humanized liver as an animal model for predicting drug effects and for studying hepatic viral infection: where to next?Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics.The role of drug metabolizing enzymes in clearance.Nitrite reduction by molybdoenzymes: a new class of nitric oxide-forming nitrite reductases.A simple litmus test for aldehyde oxidase metabolism of heteroarenes.Structure and function of mammalian aldehyde oxidases.Challenges and Opportunities with Non-CYP Enzymes Aldehyde Oxidase, Carboxylesterase, and UDP-Glucuronosyltransferase: Focus on Reaction Phenotyping and Prediction of Human Clearance.Modern advances in heterocyclic chemistry in drug discovery.An overview of aldehyde oxidase: an enzyme of emerging importance in novel drug discovery.Structure-based investigation of rat aldehyde oxidase inhibition by flavonoids.Identification of a suitable and selective inhibitor towards aldehyde oxidase catalyzed reactions.Interspecies variation in the metabolism of zoniporide by aldehyde oxidase.Metabolism of xenobiotics by aldehyde oxidase.
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P2860
Increasing recognition of the importance of aldehyde oxidase in drug development and discovery.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 23 March 2011
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Increasing recognition of the ...... rug development and discovery.
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Increasing recognition of the ...... rug development and discovery.
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type
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Increasing recognition of the ...... rug development and discovery.
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Increasing recognition of the ...... rug development and discovery.
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prefLabel
Increasing recognition of the ...... rug development and discovery.
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Increasing recognition of the ...... rug development and discovery.
@nl
P2860
P1476
Increasing recognition of the ...... rug development and discovery.
@en
P2093
Enrico Garattini
Mineko Terao
P2860
P304
P356
10.3109/03602532.2011.560606
P407
P577
2011-03-23T00:00:00Z