TDP-43: the relationship between protein aggregation and neurodegeneration in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
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Altered ribostasis: RNA-protein granules in degenerative disordersPrion-like Mechanism in Amyotrophic Lateral Sclerosis: are Protein Aggregates the Key?The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth.Motor neurons and glia exhibit specific individualized responses to TDP-43 expression in a Drosophila model of amyotrophic lateral sclerosis.Targeting RNA binding proteins involved in neurodegeneration.Characterization of a series of 4-aminoquinolines that stimulate caspase-7 mediated cleavage of TDP-43 and inhibit its function.Slow development of ALS-like spinal cord pathology in mutant valosin-containing protein gene knock-in mice.TDP-43 protein variants as biomarkers in amyotrophic lateral sclerosis.Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BPExposure to ALS-FTD-CSF generates TDP-43 aggregates in glioblastoma cells through exosomes and TNTs-like structure.TDP-43 in central nervous system development and function: clues to TDP-43-associated neurodegeneration.Regulatory consequences of neuronal ELAV-like protein binding to coding and non-coding RNAs in human brain.Asparaginyl endopeptidase cleaves TDP-43 in brainChanges in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans.Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones.TDP-43 inclusion bodies formed in bacteria are structurally amorphous, non-amyloid and inherently toxic to neuroblastoma cells.Evolutionarily conserved heterogeneous nuclear ribonucleoprotein (hnRNP) A/B proteins functionally interact with human and Drosophila TAR DNA-binding protein 43 (TDP-43).TDP-43 and FUS/TLS: sending a complex message about messenger RNA in amyotrophic lateral sclerosis?Protein aggregation in amyotrophic lateral sclerosis.Immune-mediated mechanisms in the pathoprogression of amyotrophic lateral sclerosis.RNA-binding proteins associated molecular mechanisms of motor neuron degeneration pathogenesis.TDP-43 aggregation mirrors TDP-43 knockdown, affecting the expression levels of a common set of proteins.Quantification of the Relative Contributions of Loss-of-function and Gain-of-function Mechanisms in TAR DNA-binding Protein 43 (TDP-43) ProteinopathiesEnergy Homeostasis and Abnormal RNA Metabolism in Amyotrophic Lateral SclerosisCellular model of TAR DNA-binding protein 43 (TDP-43) aggregation based on its C-terminal Gln/Asn-rich region.Drosophila Answers to TDP-43 Proteinopathies.Novel atomic force microscopy based biopanning for isolation of morphology specific reagents against TDP-43 variants in amyotrophic lateral sclerosis.Platelet phosphorylated TDP-43: an exploratory study for a peripheral surrogate biomarker development for Alzheimer's disease.The Biological Basis of Chronic Traumatic Encephalopathy following Blast Injury: A Literature Review.Transportin 1 accumulates in FUS inclusions in adult-onset ALS without FUS mutation.Ethnopharmacological Approaches for Dementia Therapy and Significance of Natural Products and Herbal Drugs.Blood-Based Oligomeric and Other Protein Variant Biomarkers to Facilitate Pre-Symptomatic Diagnosis and Staging of Alzheimer's Disease.Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism
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TDP-43: the relationship between protein aggregation and neurodegeneration in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 24 August 2011
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
TDP-43: the relationship betwe ...... totemporal lobar degeneration.
@en
TDP-43: the relationship betwe ...... totemporal lobar degeneration.
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type
label
TDP-43: the relationship betwe ...... totemporal lobar degeneration.
@en
TDP-43: the relationship betwe ...... totemporal lobar degeneration.
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prefLabel
TDP-43: the relationship betwe ...... totemporal lobar degeneration.
@en
TDP-43: the relationship betwe ...... totemporal lobar degeneration.
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P1433
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TDP-43: the relationship betwe ...... totemporal lobar degeneration.
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P2093
Robert H Baloh
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P304
P356
10.1111/J.1742-4658.2011.08256.X
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P577
2011-08-24T00:00:00Z