Developmental biology of T cells in T cell-receptor transgenic mice.
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Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activationThe human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elementsLack of allelic exclusion in B cell chronic lymphocytic leukemiaThe Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesisNo requirement for V(D)J recombination in p53-deficient thymic lymphomaLineage diversion of T cell receptor transgenic thymocytes revealed by lineage fate mapping.Genetic Modeling of PIM Proteins in Cancer: Proviral Tagging and Cooperation with Oncogenes, Tumor Suppressor Genes, and Carcinogens.Thymic nurse cells exhibit epithelial progenitor phenotype and create unique extra-cytoplasmic membrane space for thymocyte selectionT cells from epicutaneously immunized mice are prone to T cell receptor revisionAdjacent DNA elements dominantly restrict the ubiquitous activity of a novel chromatin-opening region to specific tissues.A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytesLong-term in vivo provision of antigen-specific T cell immunity by programming hematopoietic stem cells.Interactions between double positive thymocytes and high affinity ligands presented by cortical epithelial cells generate double negative thymocytes with T cell regulatory activity.Generation of functional antigen-specific T cells in defined genetic backgrounds by retrovirus-mediated expression of TCR cDNAs in hematopoietic precursor cells.T cell-intrinsic and -extrinsic contributions of the IFNAR/STAT1-axis to thymocyte survival.Dynamic recruitment of Ets1 to both nucleosome-occupied and -depleted enhancer regions mediates a transcriptional program switch during early T-cell differentiation.The role of the thymus in tolerance.PKCtheta is necessary for efficient activation of NFkappaB, NFAT, and AP-1 during positive selection of thymocytes.The ubiquitously expressed Csk adaptor protein Cbp is dispensable for embryogenesis and T-cell development and functionThe impact of pre-T-cell receptor signals on gene expression in developing T cells.Restricted heterogeneity of T lymphocytes in combined immunodeficiency with hypereosinophilia (Omenn's syndrome).The cytoplasmic tail of the T cell receptor CD3 epsilon subunit contains a phospholipid-binding motif that regulates T cell functions.Apoptosis-linked gene 2-deficient mice exhibit normal T-cell development and functionElements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination.Development of CD4+ T cells expressing a nominally MHC class I-restricted T cell receptor by two different mechanisms.Facilitation of beta selection and modification of positive selection in the thymus of PD-1-deficient miceCBAP promotes thymocyte negative selection by facilitating T-cell receptor proximal signalingThe anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression.GILT accelerates autoimmunity to the melanoma antigen tyrosinase-related protein 1.A critical role for the regulated wnt-myc pathway in naive T cell survivalEfficient T cell repertoire selection in tetraparental chimeric mice independent of thymic epithelial MHCStochastic component to development of class I major histocompatibility complex-specific T cellsMutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection.Genomics-based identification of self-ligands with T cell receptor-specific biological activity.Monitoring the T cell response to genital tract infection.Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene.Thymic selection revisited: how essential is it?Functional CD8+ but not CD4+ T cell responses develop independent of thymic epithelial MHC.The control of apoptosis in lymphocyte selection.Negative selection of CD4+ CD8+ thymocytes by T-cell receptor peptide antagonists.
P2860
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P2860
Developmental biology of T cells in T cell-receptor transgenic mice.
description
article científic
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article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
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artikull shkencor
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artículo científico
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name
Developmental biology of T cells in T cell-receptor transgenic mice.
@en
Developmental biology of T cells in T cell-receptor transgenic mice.
@nl
type
label
Developmental biology of T cells in T cell-receptor transgenic mice.
@en
Developmental biology of T cells in T cell-receptor transgenic mice.
@nl
prefLabel
Developmental biology of T cells in T cell-receptor transgenic mice.
@en
Developmental biology of T cells in T cell-receptor transgenic mice.
@nl
P1476
Developmental biology of T cells in T cell-receptor transgenic mice.
@en
P2093
von Boehmer H
P304
P356
10.1146/ANNUREV.IMMUNOL.8.1.531
P577
1990-01-01T00:00:00Z