Human globin locus activation region (LAR): role in temporal control.
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Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4Heterologous introns can enhance expression of transgenes in miceCloning and functional characterization of LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expressionA recurrent intragenic deletion mutation in DSG4 gene in three Pakistani families with autosomal recessive hypotrichosisHuman gamma-globin gene promoter element regulates human beta-globin gene developmental specificityA general approach for identifying distant regulatory elements applied to the Gdf6 gene.Mouse model of human beta zero thalassemia: targeted deletion of the mouse beta maj- and beta min-globin genes in embryonic stem cells.Function of the upstream hypersensitive sites of the chicken beta-globin gene cluster in mice.Multiple elements in human beta-globin locus control region 5' HS 2 are involved in enhancer activity and position-independent, transgene expressionFurther understanding of the beta-globin locus regulation at the molecular level: looping or linking models?The beta-globin locus control region enhances transcription of but does not confer position-independent expression onto the lacZ gene in transgenic mice.Lethal thalassemia after insertional disruption of the mouse major adult beta-globin gene.Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferases.YAC transgenes: bigger is probably better.An "in-out" strategy using gene targeting and FLP recombinase for the functional dissection of complex DNA regulatory elements: analysis of the beta-globin locus control region.The human growth hormone gene is regulated by a multicomponent locus control region.Expression of the chicken beta-globin gene cluster in mice: correct developmental expression and distributed control.Position independence and proper developmental control of gamma-globin gene expression require both a 5' locus control region and a downstream sequence element.An enhancer/locus control region is not sufficient to open chromatin.Identification and characterization of a beta-globin promoter-binding factor from murine erythroleukemia cellsRole of gene order in developmental control of human gamma- and beta-globin gene expression.Distal regulatory elements from the mouse metallothionein locus stimulate gene expression in transgenic miceHigh-level expression of the rat whey acidic protein gene is mediated by elements in the promoter and 3' untranslated region.Relationship of eukaryotic DNA replication to committed gene expression: general theory for gene controlPersistent fetal gamma-globin expression in adult transgenic mice following deletion of two silencer elements located 3' to the human Agamma-globin gene.Human beta-globin locus control region: analysis of the 5' DNase I hypersensitive site HS 2 in transgenic miceThe erythroid Krüppel-like factor transactivation domain is a critical component for cell-specific inducibility of a beta-globin promoter.Distinct negative regulation of the human embryonic globin genes zeta and epsilon.DNase I hypersensitivity patterns of the serglycin proteoglycan gene in resting and phorbol 12-myristate 13-acetate-stimulated human erythroleukemia (HEL), CHRF 288-11, and HL-60 cells compared with neutrophils and human umbilical vein endothelial cErythroid Krüppel-like factor (EKLF) contains a multifunctional transcriptional activation domain important for inter- and intramolecular interactions.Site-specific acetylation by p300 or CREB binding protein regulates erythroid Krüppel-like factor transcriptional activity via its interaction with the SWI-SNF complex.Position effects in mice carrying a lacZ transgene in cis with the beta-globin LCR can be explained by a graded model.Oct4 dependence of chromatin structure within the extended Nanog locus in ES cells.Established epigenetic modifications determine the expression of developmentally regulated globin genes in somatic cell hybridsSheltering of gamma-globin expression from position effects requires both an upstream locus control region and a regulatory element 3' to the A gamma-globin geneLoss of Major DNase I Hypersensitive Sites in Duplicated β-globin Gene Cluster Incompletely Silences HBB Gene Expression.Characterization of the major regulatory element upstream of the human alpha-globin gene cluster.Signals in chicken beta-globin DNA influence chromatin assembly in vitroErythroid regulatory elements.Contrasting effects of alpha and beta globin regulatory elements on chromatin structure may be related to their different chromosomal environments.
P2860
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P2860
Human globin locus activation region (LAR): role in temporal control.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Human globin locus activation region (LAR): role in temporal control.
@en
Human globin locus activation region
@nl
type
label
Human globin locus activation region (LAR): role in temporal control.
@en
Human globin locus activation region
@nl
prefLabel
Human globin locus activation region (LAR): role in temporal control.
@en
Human globin locus activation region
@nl
P1433
P1476
Human globin locus activation region (LAR): role in temporal control.
@en
P2093
Behringer RR
P304
P356
10.1016/0168-9525(90)90182-6
P577
1990-07-01T00:00:00Z