Multiple elements in human beta-globin locus control region 5' HS 2 are involved in enhancer activity and position-independent, transgene expression
about
Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 siteInteraction of NF-E2 in the human beta-globin locus control region before chromatin remodelingHigh-mobility group protein 2 may be involved in the locus control region regulation of the beta-globin gene clusterhMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2Effect of deletion of 5'HS3 or 5'HS2 of the human beta-globin locus control region on the developmental regulation of globin gene expression in beta-globin locus yeast artificial chromosome transgenic mice.A negative cis-element regulates the level of enhancement by hypersensitive site 2 of the beta-globin locus control region.Requirements for utilization of CREB binding protein by hypersensitive site two of the beta-globin locus control regionStructural and functional cross-talk between a distant enhancer and the epsilon-globin gene promoter shows interdependence of the two elements in chromatin.Sequences flanking hypersensitive sites of the beta-globin locus control region are required for synergistic enhancementGeneration of a high-titer retroviral vector capable of expressing high levels of the human beta-globin gene.Retroviral vector sequences inhibit human beta-globin gene expression in transgenic mice.The beta-globin promoter is important for recruitment of erythroid Krüppel-like factor to the locus control region in erythroid cellsReactivation of silenced, virally transduced genes by inhibitors of histone deacetylase.Mitogen-activated protein kinases enhance long-range activation by the beta-globin locus control region.Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferases.LCR 5' hypersensitive site specificity for globin gene activation within the active chromatin hub.Targeting a SWI/SNF-related chromatin remodeling complex to the beta-globin promoter in erythroid cells.Essential role of NF-E2 in remodeling of chromatin structure and transcriptional activation of the epsilon-globin gene in vivo by 5' hypersensitive site 2 of the beta-globin locus control regionTranscription of the HS2 enhancer toward a cis-linked gene is independent of the orientation, position, and distance of the enhancer relative to the gene.Winner of the Theodore E. Woodward Award: c-Myb and the coordinate regulation of thymic genes.Identification and functional characterization of an erythroid-specific enhancer in the L-type pyruvate kinase gene.Transcriptional mechanisms underlying hemoglobin synthesis.A novel DNA-binding protein, HS2NF5, interacts with a functionally important sequence of the human beta-globin locus control region.Slow and Steady Wins The Race? Progress in the Development of Vectors for Gene Therapy of β-Thalassemia and Sickle Cell Disease.Enhancer activity of HS2 of the human beta-LCR is modulated by distance from the key nucleosomeSite-specific acetylation by p300 or CREB binding protein regulates erythroid Krüppel-like factor transcriptional activity via its interaction with the SWI-SNF complex.Sequences within and flanking hypersensitive sites 3 and 2 of the beta-globin locus control region required for synergistic versus additive interaction with the epsilon-globin gene promoter.Stochastic, stage-specific mechanisms account for the variegation of a human globin transgeneA central role for a single c-Myb binding site in a thymic locus control region.Stage-specific repression by the EKLF transcriptional activator.The roles of 5'-HS2, 5'-HS3, and the gamma-globin TATA, CACCC, and stage selector elements in suppression of beta-globin expression in early development.Identification of a cell type-specific enhancer in the distal 5'-region of the platelet-derived growth factor A-chain gene.Role of DNA sequences outside the cores of DNase hypersensitive sites (HSs) in functions of the beta-globin locus control region. Domain opening and synergism between HS2 and HS3.Two mutations in the locus control region hypersensitivity site-2 (5' HS-2) of haplotype 19 beta s chromosomes alter binding of trans-acting factors.Role of erythroid Kruppel-like factor in human gamma- to beta-globin gene switching.Binding of upstream stimulatory factor to an E-box in the 3'-flanking region stimulates alpha1(I) collagen gene transcription.The human gamma-globin TATA and CACCC elements have key, distinct roles in suppressing beta-globin gene expression in embryonic/fetal development.A WW domain-binding motif within the activation domain of the hematopoietic transcription factor NF-E2 is essential for establishment of a tissue-specific histone modification pattern.Analysis of indel variations in the human disease-associated genes CDKN2AIP, WDR66, USP20 and OR7C2 in a Korean population.cAMP-dependent protein kinase is necessary for increased NF-E2.DNA complex formation during erythroleukemia cell differentiation.
P2860
Q24647985-DC527A89-B946-43F3-9E3C-8F2ADA6942CEQ28201249-6B9A9151-52FE-4E4E-BEEC-930156B276A2Q28205845-8FD20C62-20CE-437E-B254-9F5E3B58F6C8Q28241711-C249B161-9688-4054-83D2-78519882FF26Q30453906-06E88892-9F4E-4123-85BE-53CB682F714AQ31621466-D4DD0C5B-E8D0-469C-89E1-04C171FAD286Q33600935-BBF48C8A-0247-4A2F-B179-62685BD2EFD5Q33960162-E9B5A9B0-AC81-45B4-82BC-9CA09300E3BFQ33967973-458F0D5D-FF2C-40C6-94F8-121BD80683AAQ34073641-D1BED537-50A0-40D6-A692-F076E9780C54Q34889496-0D3FE550-C909-475D-A133-CBE78997F52CQ35613879-E8B9349F-D134-433D-BAC7-C31F0402EDC5Q36159085-C5F91075-9F8A-4EB4-B00F-8085098CD3F3Q36217970-991C2CE6-046B-4511-9EA2-1200FB917B62Q36278311-CDF3975E-9F7C-4870-AB27-AFC1E4BDD01CQ36477978-5DE1E301-927A-4E18-ADAB-5266A7007FB5Q36536140-45B38EC1-A771-4D6A-9D44-CA49084ABE2FQ36563365-CD8D51D5-9EF2-4453-8CC0-D7589B75EB16Q36569298-98C5A36B-4FB6-4F6C-A9C3-C920C60B7955Q36647250-D0F68908-1FAC-44FD-B0C0-47F5B08BB469Q36709618-65AC2F3B-7247-4529-A313-BC42FCB8596FQ37122360-F3EBA3A4-BCE1-4C23-B082-917BE927E6DCQ38350604-A77BBEB7-E3A1-4224-9733-8C9229A67DE9Q38900001-18C61B67-EC8E-4735-8318-25EEE15D3D4BQ39097055-229C3F90-84FC-4FDA-BFE3-B2B4E2115E1CQ39458728-80AB07E2-67B9-454A-9343-3B2DAA1CC038Q39717999-27F9F50E-EFE9-4F6E-8027-CD58F4D8E335Q39724287-D824D29B-2796-4433-9BB1-007BD00ABEF9Q40017390-8F3B7902-429E-4520-BDC5-9A7B6E15CCE3Q40419424-85DB5A74-FCB4-4317-9EF0-5BED37038C19Q40962046-67887F11-6A74-4773-A528-142EADB823A0Q40990322-C9483DAF-E091-402E-B0AA-0BE541F33707Q41198164-A3822E06-E1D3-45A7-A936-E77213036355Q41254584-23AEF498-8BBA-4379-9B06-D0B97965E92FQ41378880-EC3B46E9-EE49-4237-B35F-859FC7CC83A2Q42804627-D947B1EC-89E0-4BF4-B4BC-A9A782A3FE16Q43733961-1E48F055-64EC-42C9-B4CE-ED18FA067639Q44642038-85C38448-33DA-4B66-918E-0116EA94143DQ45400688-AC35D4F5-9FB3-4E68-9C27-ECD4C74CFDF9Q46130409-54C549F7-DA94-46F4-A82A-893A9E8A5BAE
P2860
Multiple elements in human beta-globin locus control region 5' HS 2 are involved in enhancer activity and position-independent, transgene expression
description
1994 nî lūn-bûn
@nan
1994 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի մարտին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Multiple elements in human bet ...... ependent, transgene expression
@ast
Multiple elements in human bet ...... ependent, transgene expression
@en
Multiple elements in human bet ...... ependent, transgene expression
@nl
type
label
Multiple elements in human bet ...... ependent, transgene expression
@ast
Multiple elements in human bet ...... ependent, transgene expression
@en
Multiple elements in human bet ...... ependent, transgene expression
@nl
prefLabel
Multiple elements in human bet ...... ependent, transgene expression
@ast
Multiple elements in human bet ...... ependent, transgene expression
@en
Multiple elements in human bet ...... ependent, transgene expression
@nl
P2093
P2860
P356
P1476
Multiple elements in human bet ...... ependent, transgene expression
@en
P2093
D J Ciavatta
J J Caterina
R R Behringer
T M Townes
P2860
P304
P356
10.1093/NAR/22.6.1006
P407
P50
P577
1994-03-01T00:00:00Z