Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

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http://www.wikidata.org/entity/Q38289583

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Induction of murine NAD(P)H:quinone oxidoreductase by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires the CNC (cap n collar) basic leucine zipper transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2)Vanin-1-/- mice exhibit a glutathione-mediated tissue resistance to oxidative stress Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element Common features and interesting differences in transcriptional responses to secretion stress in the fungi Trichoderma reesei and Saccharomyces cerevisiae The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance Redox Modulating NRF2: A Potential Mediator of Cancer Stem Cell Resistance The Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseases Cytoprotective Nrf2 pathway is induced in chronically txnrd 1-deficient hepatocytes Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by KIAA0132, the human homolog to INrf2 Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes Protective role for ovarian glutathione S-transferase isoform pi during 7,12-dimethylbenz[a]anthracene-induced ovotoxicity Nuclear Factor-Erythroid-2-Related Factor 2 in Aging and Lung Fibrosis Nrf2 is a potential prognostic marker and promotes proliferation and invasion in human hepatocellular carcinoma 4-Hydroxy-2-nonenal induces apoptosis by activating ERK1/2 signaling and depleting intracellular glutathione in intestinal epithelial cells The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice The role of Nrf1 and Nrf2 in the regulation of copper-responsive transcription Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay Glutathione-S-transferase A3 knockout mice are sensitive to acute cytotoxic and genotoxic effects of aflatoxin B1 Cloning and expression of a novel Mu class murine glutathione transferase isoenzyme Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1 Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress Loss of GSTM1, a NRF2 target, is associated with accelerated progression of hypertensive kidney disease in the African American Study of Kidney Disease (AASK).Effects of the antioxidant drug tempol on renal oxygenation in mice with reduced renal mass.Glutathione S-transferase-micro1 regulates vascular smooth muscle cell proliferation, migration, and oxidative stress.A genomic screen for activators of the antioxidant response element Transcriptome profiles of carcinoma-in-situ and invasive non-small cell lung cancer as revealed by SAGE Nrf2 signaling, a mechanism for cellular stress resistance in long-lived mice.Genetic or pharmacologic activation of Nrf2 signaling fails to protect against aflatoxin genotoxicity in hypersensitive GSTA3 knockout mice Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype.Mammary gene expression profiles during an intramammary challenge reveal potential mechanisms linking negative energy balance with impaired immune response Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism.NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology.Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver.Growth hormone alters the glutathione S-transferase and mitochondrial thioredoxin systems in long-living Ames dwarf mice.

P2860

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P2860

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

Item

http://www.wikidata.org/entity/Q38289583

description

2002 nî lūn-bûn

@nan

2002年の論文

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2002年学术文章

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2002年学术文章

@zh-cn

2002年学术文章

@zh-hans

2002年学术文章

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2002年学术文章

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2002年學術文章

@yue

2002年學術文章

@zh

2002年學術文章

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name

Loss of the Nrf2 transcription ...... ivers of male and female mice.

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type

Item

label

Loss of the Nrf2 transcription ...... ivers of male and female mice.

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Loss of the Nrf2 transcription ...... ivers of male and female mice.

@en

P1476

Loss of the Nrf2 transcription ...... livers of male and female mice

@en

P2093

Clifford R Elcombe

http://www.w3.org/2001/XMLSchema#string

Gail K McWalter

http://www.w3.org/2001/XMLSchema#string

Graeme J Moffat

http://www.w3.org/2001/XMLSchema#string

Ken Itoh

http://www.w3.org/2001/XMLSchema#string

Lesley I McLellan

http://www.w3.org/2001/XMLSchema#string

Masayuki Yamamoto

http://www.w3.org/2001/XMLSchema#string

Michael McMahon

http://www.w3.org/2001/XMLSchema#string

Qing Jiang

http://www.w3.org/2001/XMLSchema#string

Simon A Chanas

http://www.w3.org/2001/XMLSchema#string

P2860

Rationale for reclassification of a distinctive subdivision of mammalian class Mu glutathione S-transferases that are primarily expressed in testis

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene

The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity

Molecular cloning and heterologous expression of a cDNA encoding a mouse glutathione S-transferase Yc subunit possessing high catalytic activity for aflatoxin B1-8,9-epoxide

Hepatic glutathione S-transferases in mice fed on a diet containing the anticarcinogenic antioxidant butylated hydroxyanisole. Isolation of mouse glutathione S-transferase heterodimers by gradient elution of the glutathione-Sepharose affinity matrix

Regulation of mouse glutathione S-transferases by chemoprotectors. Molecular evidence for the existence of three distinct alpha-class glutathione S-transferase subunits, Ya1, Ya2, and Ya3, in mouse liver

Nrf2 is essential for protection against acute pulmonary injury in mice

P304

405-416

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P31

scholarly article

P356

10.1042/BJ20020320

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English

P433

Pt 2

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P478

365

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P50

John D. Hayes

Colin J Henderson

C R Wolf

P577

2002-07-01T00:00:00Z

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P698

11991805

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P932

1222698

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Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

about

P2860

P2860

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

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P1433

P1476

P2093

P2860

P304

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P356

P407

P433

P478

P50

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P356

P1433

P1476

P2093

P2860

P304

P31

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P932