Recombinant junctions formed by site-specific integration of adeno-associated virus into an episome.
about
Latent adeno-associated virus infection elicits humoral but not cell-mediated immune responses in a nonhuman primate modelMembrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virionsEfficient integration of recombinant adeno-associated virus DNA vectors requires a p5-rep sequence in cis.Adeno-associated virus Rep proteins target DNA sequences to a unique locus in the human genomeExpression of human herpesvirus 6B rep within infected cells and binding of its gene product to the TATA-binding protein in vitro and in vivo.Adeno-associated virus site-specifically integrates into a muscle-specific DNA regionGenetic fate of recombinant adeno-associated virus vector genomes in muscleTargeted chromosomal insertion of large DNA into the human genome by a fiber-modified high-capacity adenovirus-based vector system.Development of animal models for adeno-associated virus site-specific integration.Adeno-associated virus vectors and hematologyStable secondary structure near the nicking site for adeno-associated virus type 2 Rep proteins on human chromosome 19Rescue and autonomous replication of adeno-associated virus type 2 genomes containing Rep-binding site mutations in the viral p5 promoter.Characterization of wild-type adeno-associated virus type 2-like particles generated during recombinant viral vector production and strategies for their eliminationSite-specific integration of adeno-associated virus into an episome with the target locus via a deletion-substitution mechanismAn adeno-associated virus (AAV) initiator protein, Rep78, catalyzes the cleavage and ligation of single-stranded AAV ori DNA.Isolation of recombinant adeno-associated virus vector-cellular DNA junctions from mouse liver.Transfer of the full-length dystrophin-coding sequence into muscle cells by a dual high-capacity hybrid viral vector with site-specific integration abilityHigh mobility group chromosomal protein 1 binds to the adeno-associated virus replication protein (Rep) and promotes Rep-mediated site-specific cleavage of DNA, ATPase activity and transcriptional repression.Substitution of adeno-associated virus Rep protein binding and nicking sites with human chromosome 19 sequences.A p5 integration efficiency element mediates Rep-dependent integration into AAVS1 at chromosome 19.Herpes simplex virus type 1/adeno-associated virus hybrid vectors mediate site-specific integration at the adeno-associated virus preintegration site, AAVS1, on human chromosome 19.Adeno-associated viruses undergo substantial evolution in primates during natural infections.Adenoviral-mediated glial cell line-derived neurotrophic factor gene transfer has a protective effect on sciatic nerve following constriction-induced spinal cord injury.Identification of an insulator in AAVS1, a preferred region for integration of adeno-associated virus DNA.Recombinant adeno-associated virus-mediated high-efficiency, transient expression of the murine cationic amino acid transporter (ecotropic retroviral receptor) permits stable transduction of human HeLa cells by ecotropic retroviral vectors.A novel terminal resolution-like site in the adeno-associated virus type 2 genome.Binding sites for adeno-associated virus Rep proteins within the human genome.Adeno-associated virus vector integration junctions.Preferential integration of adeno-associated virus type 2 into a polypyrimidine/polypurine-rich region within AAVS1.Cellular recombination pathways and viral terminal repeat hairpin structures are sufficient for adeno-associated virus integration in vivo and in vitro.Adeno-associated virus (AAV) site-specific integration: formation of AAV-AAVS1 junctions in an in vitro system.Site-specific integration by adeno-associated virusThe recombination signals for adeno-associated virus site-specific integration.A helper-dependent capsid-modified adenovirus vector expressing adeno-associated virus rep78 mediates site-specific integration of a 27-kilobase transgene cassette.Site-specific integration of an adeno-associated virus vector plasmid mediated by regulated expression of rep based on Cre-loxP recombination.DNA sequence motifs which direct adeno-associated virus site-specific integration in a model system.Kinetics and frequency of adeno-associated virus site-specific integration into human chromosome 19 monitored by quantitative real-time PCR.Packaging of human chromosome 19-specific adeno-associated virus (AAV) integration sites in AAV virions during AAV wild-type and recombinant AAV vector production.A novel 165-base-pair terminal repeat sequence is the sole cis requirement for the adeno-associated virus life cycle.Junonia coenia densovirus-based vectors for stable transgene expression in Sf9 cells: influence of the densovirus sequences on genomic integration.
P2860
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P2860
Recombinant junctions formed by site-specific integration of adeno-associated virus into an episome.
description
1995 nî lūn-bûn
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1995年の論文
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1995年学术文章
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1995年学术文章
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1995年学术文章
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1995年学术文章
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1995年學術文章
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1995年學術文章
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name
Recombinant junctions formed b ...... ociated virus into an episome.
@en
type
label
Recombinant junctions formed b ...... ociated virus into an episome.
@en
prefLabel
Recombinant junctions formed b ...... ociated virus into an episome.
@en
P2093
P2860
P1433
P1476
Recombinant junctions formed b ...... ociated virus into an episome.
@en
P2093
P2860
P304
P407
P577
1995-11-01T00:00:00Z