Dicationic diarylfurans as anti-Pneumocystis carinii agents.
about
Treatment of infection due to Pneumocystis cariniiA mouse diversity panel approach reveals the potential for clinical kidney injury due to DB289 not predicted by classical rodent modelsNovel amidines and analogues as promising agents against intracellular parasites: a systematic reviewVariability in DNA minor groove width recognised by ligand binding: the crystal structure of a bis-benzimidazole compound bound to the DNA duplex d(CGCGAATTCGCG)2Designer DNA-binding drugs: the crystal structure of a meta-hydroxy analogue of Hoechst 33258 bound to d(CGCGAATTCGCG)2Visualisation of extensive water ribbons and networks in a DNA minor-groove drug complexStructure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agentsIn vitro antifungal activities of a series of dication-substituted carbazoles, furans, and benzimidazolesComparative efficacy evaluation of dicationic carbazole compounds, nitazoxanide, and paromomycin against Cryptosporidium parvum infections in a neonatal mouse model.In-vitro activity of dicationic aromatic compounds and fluconazole against Cryptococcus neoformans and Candida sppAnti-Pneumocystis activities of aromatic diamidoxime prodrugs.The diamidine DB75 targets the nucleus of Plasmodium falciparumDevelopment of a capillary zone electrophoresis method for the separation of a furan combinatorial library.Molecular characterization of recombinant Pneumocystis carinii topoisomerase I: differential interactions with human topoisomerase I poisons and pentamidine.Characterization of a novel DNA minor-groove complex.Pafuramidine for Pneumocystis jiroveci pneumonia in HIV-infected individuals.Dicationic phenyl-2,2'-bichalcophenes and analogues as antiprotozoal agents.Understanding mixed sequence DNA recognition by novel designed compounds: the kinetic and thermodynamic behavior of azabenzimidazole diamidinesSynthesis and antiprotozoal activity of cationic 1,4-diphenyl-1H-1,2,3-triazoles.Novel diamidines with activity against Babesia divergens in vitro and Babesia microti in vivoA Personal History of Quadruplex-Small Molecule Targeting.Aromatic diamidines as antiparasitic agents.Efficacy of the novel diamidine compound 2,5-Bis(4-amidinophenyl)- furan-bis-O-Methlylamidoxime (Pafuramidine, DB289) against Trypanosoma brucei rhodesiense infection in vervet monkeys after oral administration.Design of beta-hairpin peptidomimetics that inhibit binding of alpha-helical HIV-1 Rev protein to the rev response element RNA.Design and synthesis of heterocyclic cations for specific DNA recognition: from AT-rich to mixed-base-pair DNA sequencesNeglected disease - african sleeping sickness: recent synthetic and modeling advances.Bis(N-amidinohydrazones) and N-(amidino)-N'-aryl-bishydrazones: New classes of antibacterial/antifungal agents.Anti-Pneumocystis carinii pneumonia activity of dicationic 2,4-diarylpyrimidines.Understanding the DNA binding of novel non-symmetrical guanidinium/2-aminoimidazolinium derivatives.Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes.Identification and characterization of an endo/exonuclease in Pneumocystis carinii that is inhibited by dicationic diarylfurans with efficacy against Pneumocystis pneumonia.Synthesis and antimalarial activities of a diverse set of triazole-containing furamidine analogues.Novel linear triaryl guanidines, N-substituted guanidines and potential prodrugs as antiprotozoal agents.Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum.Efficient estimation of MMGBSA-based BEs for DNA and aromatic furan amidino derivatives.Aerobic oxidative α-arylation of furans with boronic acids via Pd(ii)-catalyzed C-C bond cleavage of primary furfuryl alcohols: sustainable access to arylfurans.Using Genome Sequence to Enable the Design of Medicines and Chemical Probes.
P2860
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P2860
Dicationic diarylfurans as anti-Pneumocystis carinii agents.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Dicationic diarylfurans as anti-Pneumocystis carinii agents.
@en
type
label
Dicationic diarylfurans as anti-Pneumocystis carinii agents.
@en
prefLabel
Dicationic diarylfurans as anti-Pneumocystis carinii agents.
@en
P2093
P356
P1476
Dicationic diarylfurans as anti-Pneumocystis carinii agents.
@en
P2093
Dykstra CC
Lombardy RJ
Spychala J
Tidwell RR
P304
P356
10.1021/JM00006A009
P407
P577
1995-03-01T00:00:00Z