Three Dact gene family members are expressed during embryonic development and in the adult brains of mice.
about
DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modificationsDapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleusProtein kinase A-mediated 14-3-3 association impedes human Dapper1 to promote dishevelled degradationDapper antagonist of catenin-1 cooperates with Dishevelled-1 during postsynaptic development in mouse forebrain GABAergic interneuronsDisruption of the Dapper3 gene aggravates ureteral obstruction-mediated renal fibrosis by amplifying Wnt/β-catenin signalingDact2 is expressed in the developing ureteric bud/collecting duct system of the kidney and controls morphogenetic behavior of collecting duct cellsDact1, a nutritionally regulated preadipocyte gene, controls adipogenesis by coordinating the Wnt/beta-catenin signaling networkDact1 is a postsynaptic protein required for dendrite, spine, and excitatory synapse development in the mouse forebrainPosterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streakLoss of Dact1 disrupts planar cell polarity signaling by altering dishevelled activity and leads to posterior malformation in miceAll Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinasesModulation of the beta-catenin signaling pathway by the dishevelled-associated protein Hipk1.Epigenetic regulation of DACT2, a key component of the Wnt signalling pathway in human lung cancer.Methylation of DACT2 promotes breast cancer development by activating Wnt signalingDact2 represses PITX2 transcriptional activation and cell proliferation through Wnt/beta-catenin signaling during odontogenesis.Retinoic acid negatively regulates dact3b expression in the hindbrain of zebrafish embryos.DACT2 is frequently methylated in human gastric cancer and methylation of DACT2 activated Wnt signaling.Dact genes are chordate specific regulators at the intersection of Wnt and Tgf-β signaling pathwaysCytoplasmic HDPR1 is involved in regional lymph node metastasis and tumor development via beta-catenin accumulation in esophageal squamous cell carcinoma.Expression analysis of Dact1 in mice using a LacZ reporter.Reduced expression of DACT2 promotes hepatocellular carcinoma progression: involvement of methylation-mediated gene silencingDACT1, an antagonist to Wnt/β-catenin signaling, suppresses tumor cell growth and is frequently silenced in breast cancer.Epigenetic regulation of the Wnt signaling inhibitor DACT2 in human hepatocellular carcinoma.SEC14 and spectrin domains 1 (Sestd1) and Dapper antagonist of catenin 1 (Dact1) scaffold proteins cooperatively regulate the Van Gogh-like 2 (Vangl2) four-pass transmembrane protein and planar cell polarity (PCP) pathway during embryonic developmenA rare WNT1 missense variant overrepresented in ASD leads to increased Wnt signal pathway activation.SEC14 and Spectrin Domains 1 (Sestd1), Dishevelled 2 (Dvl2) and Dapper Antagonist of Catenin-1 (Dact1) co-regulate the Wnt/Planar Cell Polarity (PCP) pathway during mammalian developmentAberrant methylation of DACT1 and DACT2 are associated with tumor progression and poor prognosis in esophageal squamous cell carcinoma.Dapper Antagonist of Catenin-1 (Dact1) contributes to dendrite arborization in forebrain cortical interneuronsDACT2 silencing by promoter CpG methylation disrupts its regulation of epithelial-to-mesenchymal transition and cytoskeleton reorganization in breast cancer cells.Upregulation of DACT2 suppresses proliferation and enhances apoptosis of glioma cell via inactivation of YAP signaling pathwayDact1-3 mRNAs exhibit distinct expression domains during tooth development.Sestd1 Encodes a Developmentally Dynamic Synapse Protein That Complexes With BCR Rac1-GAP to Regulate Forebrain Dendrite, Spine and Synapse Formation.Methylation of DACT2 contributes to the progression of breast cancer through activating WNT signaling pathway.Comparison of adipocyte-specific gene expression from WNIN/Ob mutant obese rats, lean control, and parental control.Dact gene expression profiles suggest a role for this gene family in integrating Wnt and TGF-β signaling pathways during chicken limb development.Imprinting analysis in the Acrodysplasia region of mouse chromosome 12.Generation of orthotopically functional salivary gland from embryonic stem cells
P2860
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P2860
Three Dact gene family members are expressed during embryonic development and in the adult brains of mice.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Three Dact gene family members ...... d in the adult brains of mice.
@en
type
label
Three Dact gene family members ...... d in the adult brains of mice.
@en
prefLabel
Three Dact gene family members ...... d in the adult brains of mice.
@en
P2093
P356
P1476
Three Dact gene family members ...... d in the adult brains of mice.
@en
P2093
Benjamin N R Cheyette
Daniel A Fisher
Jun Hoshino
Nichol Baxter
Pierre-Marie Martin
Rowena Suriben
P304
P356
10.1002/DVDY.20917
P50
P577
2006-09-01T00:00:00Z