Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product.
about
P1343
Allelic heterogeneity at the equine KIT locus in dominant white (W) horsesActivating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosisCD72 negatively regulates KIT-mediated responses in human mast cellsMechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cellsMast cell homeostasis and the JAK-STAT pathwayOne-step detection of c-kit point mutations using peptide nucleic acid-mediated polymerase chain reaction clamping and hybridization probesc-kit Mutations in patients with childhood-onset mastocytosis and genotype-phenotype correlationReceptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cellsCytokine Regulation of Microenvironmental Cells in Myeloproliferative NeoplasmsPathogenesis of RON receptor tyrosine kinase in cancer cells: activation mechanism, functional crosstalk, and signaling addictionThe JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemiaDesign and pharmacology of a highly specific dual FMS and KIT kinase inhibitorA great majority of GISTs with PDGFRA mutations represent gastric tumors of low or no malignant potential.Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos inductionInduction of stem cell factor/c-Kit/slug signal transduction in multidrug-resistant malignant mesothelioma cellsMutation D816V alters the internal structure and dynamics of c-KIT receptor cytoplasmic region: implications for dimerization and activation mechanismsTargeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineagesThe radioresistance biological function of the SCF/kit signaling pathway is mediated by the zinc-finger transcription factor SlugThe adaptor 3BP2 is required for KIT receptor expression and human mast cell survivalObesity-driven disruption of haematopoiesis and the bone marrow niche.Characterization of a novel human mast cell line that responds to stem cell factor and expresses functional FcεRIEvolution of urticaria pigmentosa into indolent systemic mastocytosis: abnormal immunophenotype of mast cells without evidence of c-kit mutation ASP-816-VAL.Demonstration that mast cells, T cells, and B cells bearing the activating kit mutation D816V occur in clusters within the marrow of patients with mastocytosis.Evaluation of the kinase domain of c-KIT in canine cutaneous mast cell tumors.RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemia.Phenotypic and genotypic characteristics of mastocytosis according to the age of onset.Epstein-Barr virus associated B-cell lymphoma of brain developing in myelodysplastic syndrome with c-kit mutation (Try-557 -->stop).JAK2 V617F in myeloid disorders: what do we know now, and where are we headed?Nilotinib in patients with systemic mastocytosis: analysis of the phase 2, open-label, single-arm nilotinib registration studySequence and structure signatures of cancer mutation hotspots in protein kinasesFunctional roles of thrombopoietin-c-mpl system in essential thrombocythemia.KinMutBase, a database of human disease-causing protein kinase mutations.Effects of mutant c-Kit in early myeloid cells.Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder.The genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemiaIdentification of novel target genes of nerve growth factor (NGF) in human mastocytoma cell line (HMC-1 (V560G c-Kit)) by transcriptome analysis.Lysosomal membrane permeabilization induces cell death in human mast cells.Stem cell factor and chronic myeloid leukemia CD34+ cells.Mast cell activation syndromes: definition and classification.Animal models of soft-tissue sarcoma.
P2860
Q21090217-7F700F7F-0CA8-4082-96B8-4A74D5733D0BQ22001442-72D0CC2B-6E4A-42EE-9B69-A32878C662D6Q24297400-441979D0-E506-44DD-BE68-3A5D94431DD4Q24313261-627E8B9F-F528-42E8-A9E2-5D7FCA16F1F7Q24632515-B5367DEE-FD8E-4434-95D3-9F6E71C2CA2DQ24685763-FBD75B47-BEB8-494F-B694-2288AD7C1602Q24685927-E54D5116-942C-4EE2-9FD9-82599E3775D4Q26740953-F1576A1A-2550-4949-AC84-94A2791A1C24Q26778929-B56646CA-FB18-44C3-9B22-B2F2B2D3DA49Q26864275-BA200063-D1AD-4FE9-B24E-A3F2F625B7C9Q27266125-97E09577-1AA3-4AAE-AD2F-183C844B6790Q27676827-75910C29-1A56-4AB5-B864-6DCD92A613FCQ27824814-51D26E7B-6888-4058-B4AE-1D023503D99EQ28145948-357FF902-699E-4C59-9667-7BA1AA27551BQ28279744-6F1EF3C1-355F-4218-A610-89BA9A11D3B6Q28478611-863CB266-F66A-4D8C-B758-2ED1068D3682Q28511281-2C076CE3-5EA7-49B4-BF8D-0E4B9F06A7BEQ28513207-CD05852A-7BE4-4DCD-AA79-7EB4B1B2FC50Q30009200-29057CB3-72C7-428D-A254-C03A9B115A1EQ30367783-C72F4284-F664-49E9-9D80-F19C61E7889DQ30428097-F3085071-8112-4C40-B18C-1C79138B0AFFQ30914592-86E67CC2-E780-4DE2-BE84-833E02A70E26Q33208353-9B389D1C-9D7F-4527-ADA5-DA9DC74D63F9Q33238296-16C71C2D-A599-421A-8AB0-E4BD99E06C48Q33306326-68F5FB9D-C2AE-4C66-8CA1-403318C712EDQ33327689-92D0B1B6-5F50-4D5A-9FEE-083278EEDFC1Q33335103-8E8AD0EB-6A6F-4208-8B32-D88089758E96Q33341856-083C603E-B789-4686-B268-E2C557AD90ACQ33423072-EC2A6574-2A46-41F8-937B-58EFAB193635Q33510934-2F236DBB-0EA0-4B61-9936-3E8D86920441Q33536306-90893467-8711-4FE6-8F03-4836DA0C86D2Q33610193-6FBBB20D-A588-45A6-8DBE-55AB8069F194Q33735183-701926C8-7FD6-4455-AF8B-4CA1F606C88DQ33784323-E5857824-CD88-4921-B3ED-E199A9106940Q33796552-E9100373-4FDC-4B26-A317-B02F185CBE3CQ33875795-0D17A772-8F74-47A8-8713-DCF983CA9139Q33924209-2F13DBCD-104C-4D29-AD2D-3588D9C34E39Q33929798-F62F7B25-183F-41E7-8E88-017D9549A789Q34035582-4C32EA93-EC5E-4EE1-919A-66B0573C21C7Q34098113-FC16916A-2776-49DA-9556-05B3E1F4652D
P2860
Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Identification of mutations in ...... t activation of c-kit product.
@en
type
label
Identification of mutations in ...... t activation of c-kit product.
@en
prefLabel
Identification of mutations in ...... t activation of c-kit product.
@en
P2093
P2860
P921
P356
P1476
Identification of mutations in ...... t activation of c-kit product.
@en
P2093
Butterfield JH
Kanayama Y
Kitayama H
Koshimizu U
Sugahara H
Tsujimura T
P2860
P304
P356
10.1172/JCI116761
P407
P4510
P577
1993-10-01T00:00:00Z