Trypanosoma brucei gamma-glutamylcysteine synthetase. Characterization of the kinetic mechanism and the role of Cys-319 in cystamine inactivation.
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Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligaseMechanistic Details of Glutathione Biosynthesis Revealed by Crystal Structures of Saccharomyces cerevisiae Glutamate Cysteine LigaseStructural Basis for Feedback and Pharmacological Inhibition of Saccharomyces cerevisiae Glutamate Cysteine LigaseThe modifier subunit of Drosophila glutamate-cysteine ligase regulates catalytic activity by covalent and noncovalent interactions and influences glutathione homeostasis in vivo.Kinetic mechanism of glutathione synthetase from Arabidopsis thaliana.Genetic validation of Trypanosoma brucei glutathione synthetase as an essential enzyme.Genomic analyses reveal a conserved glutathione homeostasis pathway in the invertebrate chordate Ciona intestinalis.Biochemistry and Physiology of Heavy Metal Resistance and Accumulation in Euglena.Biochemical and biophysical characterization of Leishmania donovani gamma-glutamylcysteine synthetaseDissecting the catalytic mechanism of Trypanosoma brucei trypanothione synthetase by kinetic analysis and computational modelingATP-dependent ligases in trypanothione biosynthesis--kinetics of catalysis and inhibition by phosphinic acid pseudopeptides.Structure prediction and active site analysis of the metal binding determinants in gamma -glutamylcysteine synthetase.Drosophila melanogaster glutamate-cysteine ligase activity is regulated by a modifier subunit with a mechanism of action similar to that of the mammalian form.Probing the origins of glutathione biosynthesis through biochemical analysis of glutamate-cysteine ligase and glutathione synthetase from a model photosynthetic prokaryote.Drug target validation of the trypanothione pathway enzymes through metabolic modelling.Molecular modeling of Trypanosoma cruzi glutamate cysteine ligase and investigation of its interactions with glutathione
P2860
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P2860
Trypanosoma brucei gamma-glutamylcysteine synthetase. Characterization of the kinetic mechanism and the role of Cys-319 in cystamine inactivation.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Trypanosoma brucei gamma-gluta ...... 319 in cystamine inactivation.
@en
type
label
Trypanosoma brucei gamma-gluta ...... 319 in cystamine inactivation.
@en
prefLabel
Trypanosoma brucei gamma-gluta ...... 319 in cystamine inactivation.
@en
P2860
P356
P1476
Trypanosoma brucei gamma-gluta ...... -319 in cystamine inactivation
@en
P2093
M A Phillips
P2860
P304
26317-26322
P356
10.1074/JBC.273.41.26317
P407
P577
1998-10-01T00:00:00Z