The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity.
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Active site distortion is sufficient for proteinase inhibition by serpins: structure of the covalent complex of alpha1-proteinase inhibitor with porcine pancreatic elastaseAntithrombin-S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activationCrystal structure of monomeric native antithrombin reveals a novel reactive center loop conformationCrystal structure of an RNA aptamer bound to thrombinThrombin inhibition by the serpinsC1 inhibitor serpin domain structure reveals the likely mechanism of heparin potentiation and conformational diseaseHeparin-induced cis- and trans-Dimerization Modes of the Thrombospondin-1 N-terminal DomainMolecular simulations of carbohydrates and protein-carbohydrate interactions: motivation, issues and prospectsHeparin binds lamprey angiotensinogen and promotes thrombin inhibition through a template mechanismTargeting the GPIbα binding site of thrombin to simultaneously induce dual anticoagulant and antiplatelet effectsFinding a needle in a haystack: development of a combinatorial virtual screening approach for identifying high specificity heparin/heparan sulfate sequence(s).Chemoenzymatic synthesis of heparin oligosaccharides with both anti-factor Xa and anti-factor IIa activities.Role of the netrin-like domain of procollagen C-proteinase enhancer-1 in the control of metalloproteinase activity.Enzymatic redesigning of biologically active heparan sulfate.A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor XaStructure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin.The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition.Heparan sulfate regulates VEGF165- and VEGF121-mediated vascular hyperpermeability.Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs).Effect of the substituents of the neighboring ring in the conformational equilibrium of iduronate in heparin-like trisaccharides.On the specificity of heparin/heparan sulfate binding to proteins. Anion-binding sites on antithrombin and thrombin are fundamentally different.Structural characterization of human heparanase reveals insights into substrate recognition.Conformational activation of antithrombin by heparin involves an altered exosite interaction with protease.Designing "high-affinity, high-specificity" glycosaminoglycan sequences through computerized modelingHigh-resolution probing heparan sulfate-antithrombin interaction on a single endothelial cell surface: single-molecule AFM studies.ANISERP: a new serpin from the parasite Anisakis simplex.Hedgehogs like it sweet, too.Anticoagulant heparan sulfate: structural specificity and biosynthesis.The structure of thrombin, a chameleon-like proteinase.Glycoconjugate glycans as viral receptors.Identification of proteoglycans as the APRIL-specific binding partners.Mutation of the H-helix in antithrombin decreases heparin stimulation of protease inhibition.Thrombin.Serpins in thrombosis, hemostasis and fibrinolysisCharacterization of a heparin-binding site on the catalytic domain of factor XIa: mechanism of heparin acceleration of factor XIa inhibition by the serpins antithrombin and C1-inhibitorAdeno-associated virus-2 and its primary cellular receptor--Cryo-EM structure of a heparin complex.Serpins in T cell immunity.The allosteric mechanism of activation of antithrombin as an inhibitor of factor IXa and factor Xa: heparin-independent full activation through mutations adjacent to helix D.Exosite determinants of serpin specificity.Capillary electrophoretic study of small, highly sulfated, non-sugar molecules interacting with antithrombin.
P2860
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P2860
The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
The ternary complex of antithr ...... asis of inhibitor specificity.
@en
type
label
The ternary complex of antithr ...... asis of inhibitor specificity.
@en
prefLabel
The ternary complex of antithr ...... asis of inhibitor specificity.
@en
P2093
P2860
P356
P1476
The ternary complex of antithr ...... asis of inhibitor specificity.
@en
P2093
Alexey Dementiev
Jean-Marc Herbert
Maurice Petitou
Peter G W Gettins
P2860
P2888
P304
P356
10.1038/NSMB810
P577
2004-08-15T00:00:00Z