MDA-7 negatively regulates the beta-catenin and PI3K signaling pathways in breast and lung tumor cells.
about
Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative actionCisplatin enhances protein kinase R-like endoplasmic reticulum kinase- and CD95-dependent melanoma differentiation-associated gene-7/interleukin-24-induced killing in ovarian carcinoma cellsMDA-7/IL-24-induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK-dependent mechanism.Inhibition of multiple protective signaling pathways and Ad.5/3 delivery enhances mda-7/IL-24 therapy of malignant gliomaPERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells.IL-24 gene transfer sensitizes melanoma cells to erlotinib through modulation of the Apaf-1 and Akt signaling pathways.Secretable chaperone Grp170 enhances therapeutic activity of a novel tumor suppressor, mda-7/IL-24Key signaling nodes in mammary gland development and cancer: β-catenin.Enhancing mda-7/IL-24 therapy in renal carcinoma cells by inhibiting multiple protective signaling pathways using sorafenib and by Ad.5/3 gene deliveryTargeting breast cancer-initiating/stem cells with melanoma differentiation-associated gene-7/interleukin-24.mda-7/IL-24: a unique member of the IL-10 gene family promoting cancer-targeted toxicity.mda-7/IL-24: multifunctional cancer-specific apoptosis-inducing cytokineGene therapy progress and prospects: cancer gene therapy using tumour suppressor genes.Suppression of Her2/Neu mammary tumor development in mda-7/IL-24 transgenic miceAutocrine regulation of mda-7/IL-24 mediates cancer-specific apoptosis.Melanoma differentiation associated gene-7 (mda-7)/IL-24: a 'magic bullet' for cancer therapy?Slit-2 induces a tumor-suppressive effect by regulating beta-catenin in breast cancer cells.Focal adhesion kinase: a promising target for anticancer therapy.Contributions of integrin-linked kinase to breast cancer metastasis and tumourigenesis.The role of apoptosis in radiation oncology.Molecular targets and signaling pathways regulated by interleukin (IL)-24 in mediating its antitumor activities.Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells.Phosphorylation of interleukin (IL)-24 is required for mediating its anti-cancer activityCombination of adenoviruses expressing melanoma differentiation-associated gene-7 and chemotherapeutic agents produces enhanced cytotoxicity on esophageal carcinoma.Expression, purification, and characterization of RGD-mda-7, a His-tagged mda-7/IL-24 mutant protein.OSU-03012 enhances Ad.7-induced GBM cell killing via ER stress and autophagy and by decreasing expression of mitochondrial protective proteins.Recombinant human interleukin-24 suppresses gastric carcinoma cell growth in vitro and in vivo.Enhanced antitumor activity by a selective conditionally replicating adenovirus combining with MDA-7/interleukin-24 for B-lymphoblastic leukemia via induction of apoptosis.Enhancement of adenoviral MDA-7-mediated cell killing in human lung cancer cells by geldanamycin and its 17-allyl- amino-17-demethoxy analogue.The antitumor activity of TRAIL and IL-24 with replicating oncolytic adenovirus in colorectal cancer.Combinatorial synergy induced by adenoviral-mediated mda-7 and Herceptin in Her-2+ breast cancer cells.Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis.mda-7 gene transfer sensitizes breast carcinoma cells to chemotherapy, biologic therapies and radiotherapy: correlation with expression of bcl-2 family members.Expression of IL-24 and IL-24 receptors in human wound tissues and the biological implications of IL-24 on keratinocytes.
P2860
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P2860
MDA-7 negatively regulates the beta-catenin and PI3K signaling pathways in breast and lung tumor cells.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
MDA-7 negatively regulates the ...... n breast and lung tumor cells.
@en
type
label
MDA-7 negatively regulates the ...... n breast and lung tumor cells.
@en
prefLabel
MDA-7 negatively regulates the ...... n breast and lung tumor cells.
@en
P2093
P1433
P1476
MDA-7 negatively regulates the ...... n breast and lung tumor cells.
@en
P2093
Abner M Mhashilkar
Alexis L Stewart
Anis H Khimani
Elizabeth A Grimm
Heng-Yin Yang
Jack A Roth
Kelly K Hunt
Kerry Sieger
Rajagopal Ramesh
P304
P356
10.1016/S1525-0016(03)00170-9
P577
2003-08-01T00:00:00Z