A single, low, oral dose of a 5-carbon-linked trioxane dimer orthoester plus mefloquine cures malaria-infected mice.
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Recent advances in malaria drug discoveryAn artemisinin-derived dimer has highly potent anti-cytomegalovirus (CMV) and anti-cancer activitiesSynthesis and antimalarial efficacy of two-carbon-linked, artemisinin-derived trioxane dimers in combination with known antimalarial drugs.Malaria-infected mice are completely cured by one 6 mg/kg oral dose of a new monomeric trioxane sulfide combined with mefloquine.Antimalarial chemotherapy: artemisinin-derived dimer carbonates and thiocarbonates.Antimalarial efficacy of hydroxyethylapoquinine (SN-119) and its derivativesMalaria-infected mice live until at least day 30 after a new artemisinin-derived thioacetal thiocarbonate combined with mefloquine are administered together in a single, low, oral dose.Potent antimalarial 1,2,4-trioxanes through perhydrolysis of epoxides.The survival times of malaria-infected mice are prolonged more by several new two-carbon-linked artemisinin-derived dimer carbamates than by the trioxane antimalarial drug artemether.
P2860
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P2860
A single, low, oral dose of a 5-carbon-linked trioxane dimer orthoester plus mefloquine cures malaria-infected mice.
description
2010 nî lūn-bûn
@nan
2010年の論文
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2010年論文
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2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
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2010年论文
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name
A single, low, oral dose of a ...... e cures malaria-infected mice.
@en
type
label
A single, low, oral dose of a ...... e cures malaria-infected mice.
@en
prefLabel
A single, low, oral dose of a ...... e cures malaria-infected mice.
@en
P2093
P2860
P1476
A single, low, oral dose of a ...... e cures malaria-infected mice.
@en
P2093
Abhai Tripathi
David Sullivan
Deuk Kyu Moon
Gary H Posner
Maxime A Siegler
Sean Parkin
P2860
P304
P356
10.1016/J.BMCL.2010.09.123
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P577
2010-09-29T00:00:00Z