A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway.
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Mutations in the CCND1 and CCND2 genes are frequent events in adult patients with t(8;21)(q22;q22) acute myeloid leukemiaClioquinol induces pro-death autophagy in leukemia and myeloma cells by disrupting the mTOR signaling pathwayA virtual screen identified C96 as a novel inhibitor of phosphatidylinositol 3-kinase that displays potent preclinical activity against multiple myeloma in vitro and in vivoModulation of platelet activation and thrombus formation using a pan-PI3K inhibitor S14161.Ferroferric oxide nanoparticles induce prosurvival autophagy in human blood cells by modulating the Beclin 1/Bcl-2/VPS34 complex.A novel PI3K inhibitor PIK-C98 displays potent preclinical activity against multiple myelomaInducing cell cycle arrest and apoptosis by dimercaptosuccinic acid modified Fe3O4 magnetic nanoparticles combined with nontoxic concentration of bortezomib and gambogic acid in RPMI-8226 cells.MicroRNA-451 regulates stemness of side population cells via PI3K/Akt/mTOR signaling pathway in multiple myeloma.SC06, a novel small molecule compound, displays preclinical activity against multiple myeloma by disrupting the mTOR signaling pathwayThe Ring Finger Protein RNF6 Induces Leukemia Cell Proliferation as a Direct Target of Pre-B-cell Leukemia Homeobox 1A novel small molecule agent displays potent anti-myeloma activity by inhibiting the JAK2-STAT3 signaling pathwayPI3-kinase inhibition synergistically promoted the anti-tumor effect of lupeol in hepatocellular carcinomaThe antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity.An anti-leishmanial thiadiazine agent induces multiple myeloma cell apoptosis by suppressing the nuclear factor kappaB signalling pathway.Identification of a promising PI3K inhibitor for the treatment of multiple myeloma through the structural optimization.Kinase inhibitors as potential agents in the treatment of multiple myeloma.The genetic architecture of multiple myeloma.Synthesis of sulfonylhydrazone- and acylhydrazone-substituted 8-ethoxy-3-nitro-2H-chromenes as potent antiproliferative and apoptosis inducing agents.Cyproheptadine-induced myeloma cell apoptosis is associated with inhibition of the PI3K/AKT signaling.A deuterated analog of dasatinib disrupts cell cycle progression and displays anti-non-small cell lung cancer activity in vitro and in vivo.A Promising Combo Gene Delivery System Developed from (3-Aminopropyl)triethoxysilane-Modified Iron Oxide Nanoparticles and Cationic PolymersPoly-(allylamine hydrochloride)-coated but not poly(acrylic acid)-coated upconversion nanoparticles induce autophagy and apoptosis in human blood cancer cells
P2860
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P2860
A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
A small-molecule inhibitor of ...... phoinositide 3-kinase pathway.
@en
A small-molecule inhibitor of ...... phoinositide 3-kinase pathway.
@nl
type
label
A small-molecule inhibitor of ...... phoinositide 3-kinase pathway.
@en
A small-molecule inhibitor of ...... phoinositide 3-kinase pathway.
@nl
prefLabel
A small-molecule inhibitor of ...... phoinositide 3-kinase pathway.
@en
A small-molecule inhibitor of ...... phoinositide 3-kinase pathway.
@nl
P2093
P50
P1433
P1476
A small-molecule inhibitor of ...... sphoinositide 3-kinase pathway
@en
P2093
Jeffery Wrana
Jiefei Tong
Michael F Moran
Neil MacLean
Rose Hurren
Tabitha E Wood
Wenjie Wang
Wenxian Sun
P304
P356
10.1182/BLOOD-2010-05-284810
P407
P577
2010-12-06T00:00:00Z