Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras.
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Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens.Synthetic lethality and cancer.Drugging RAS: Know the enemy.RAS Proteins and Their Regulators in Human Disease.Synthetic essentiality: Targeting tumor suppressor deficiencies in cancer.CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer.Optimised metrics for CRISPR-KO screens with second-generation gRNA libraries.Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibitionMultiple regulatory mechanisms of the biological function of NRF3 (NFE2L3) control cancer cell proliferation.Autophagy-Independent Lysosomal Targeting Regulated by ULK1/2-FIP200 and ATG9.CRISPR-STOP: gene silencing through base-editing-induced nonsense mutations.The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells.Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity.Correcting CRISPR for copy number.SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway.Domesticating Cancer: An Evolutionary Strategy in the War on Cancer.CRISPR/Cas9-mediated gene knockout is insensitive to target copy number but is dependent on guide RNA potency and Cas9/sgRNA threshold expression level.Posttranslational Modifications of RAS Proteins.ER stress signaling promotes the survival of cancer 'persister cells' tolerant to EGFR tyrosine kinase inhibitors.Am I ready for CRISPR? A user's guide to genetic screens.CRISPR/Cas9 library screening for drug target discovery.Emerging and evolving concepts in gene essentiality.PICKLES: the database of pooled in-vitro CRISPR knockout library essentiality screens.CRISPR-UMI: single-cell lineage tracing of pooled CRISPR-Cas9 screens.Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells.Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma.Silencing of retrotransposons by SETDB1 inhibits the interferon response in acute myeloid leukemia.Emerging Opportunities for Target Discovery in Rare Cancers.The Rac GTPase in Cancer: From Old Concepts to New Paradigms.Targeting Ras signaling in AML: RALB is a small GTPase with big potential.Improved detection of synthetic lethal interactions in Drosophila cells using variable dose analysis (VDA).Generation of an arrayed CRISPR-Cas9 library targeting epigenetic regulators: from high-content screens to in vivo assays.Synthetic Lethal Vulnerabilities in KRAS-Mutant Cancers.A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs.Atomic structure of the eukaryotic intramembrane RAS methyltransferase ICMT.New weapons to penetrate the armor: Novel reagents and assays developed at the NCI RAS Initiative to enable discovery of RAS therapeutics.Toward an integrated map of genetic interactions in cancer cells.The phenotype control kernel of a biomolecular regulatory network.Application of CRISPR-Cas9 Based Genome-Wide Screening Approaches to Study Cellular Signalling Mechanisms.
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P2860
Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras.
description
2017 nî lūn-bûn
@nan
2017年の論文
@ja
2017年論文
@yue
2017年論文
@zh-hant
2017年論文
@zh-hk
2017年論文
@zh-mo
2017年論文
@zh-tw
2017年论文
@wuu
2017年论文
@zh
2017年论文
@zh-cn
name
Gene Essentiality Profiling Re ...... teractions with Oncogenic Ras.
@en
type
label
Gene Essentiality Profiling Re ...... teractions with Oncogenic Ras.
@en
prefLabel
Gene Essentiality Profiling Re ...... teractions with Oncogenic Ras.
@en
P2093
P2860
P50
P1433
P1476
Gene Essentiality Profiling Re ...... nteractions with Oncogenic Ras
@en
P2093
Arek Kendirli
Bingxu Liu
Klara Klein
Nicholas W Hughes
P2860
P304
890-903.e15
P356
10.1016/J.CELL.2017.01.013
P407
P577
2017-02-02T00:00:00Z