Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma. - Wikidata - awgldk - TriplyDB

Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma.

Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma.

http://www.wikidata.org/entity/Q39239580

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Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting Twenty Years on: What Do We Really Know about Ewing Sarcoma and What Is the Path Forward?Sequencing Overview of Ewing Sarcoma: A Journey across Genomic, Epigenomic and Transcriptomic Landscapes Potential approaches to the treatment of Ewing's sarcoma Recent advances in targeted therapy for Ewing sarcoma KDM1 class flavin-dependent protein lysine demethylases ROMA: Representation and Quantification of Module Activity from Target Expression Data.New strategies in ewing sarcoma: lost in translation?Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma.Reversible inhibition of lysine specific demethylase 1 is a novel anti-tumor strategy for poorly differentiated endometrial carcinoma.Epigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1.Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis.PI3K/AKT signaling modulates transcriptional expression of EWS/FLI1 through specificity protein 1.High-throughput small molecule screen identifies inhibitors of aberrant chromatin accessibility.Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome Inhibitors Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells.MicroRNAs in Ewing Sarcoma.Oncogenic ETS fusions deregulate E2F3 target genes in Ewing sarcoma and prostate cancer A novel role for keratin 17 in coordinating oncogenic transformation and cellular adhesion in Ewing sarcoma.Helicase CHD4 is an epigenetic coregulator of PAX3-FOXO1 in alveolar rhabdomyosarcoma.BET bromodomain inhibitors suppress EWS-FLI1-dependent transcription and the IGF1 autocrine mechanism in Ewing sarcoma.RING1B contributes to Ewing sarcoma development by repressing the NaV1.6 sodium channel and the NF-κB pathway, independently of the fusion oncoprotein.Tumorigenicity of Ewing sarcoma is critically dependent on the trithorax proteins MLL1 and menin.Advances in therapy for pediatric sarcomas.Blocking the road, stopping the engine or killing the driver? Advances in targeting EWS/FLI-1 fusion in Ewing sarcoma as novel therapy.Structure-function based molecular relationships in Ewing's sarcoma.EWS/FLI1 Target Genes and Therapeutic Opportunities in Ewing Sarcoma.Role for the EWS domain of EWS/FLI in binding GGAA-microsatellites required for Ewing sarcoma anchorage independent growth.Activation of Wnt/β-Catenin in Ewing Sarcoma Cells Antagonizes EWS/ETS Function and Promotes Phenotypic Transition to More Metastatic Cell States.Inhibitors of LSD1 as a potential therapy for acute myeloid leukemia.Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth.Suppression of FOXO1 is responsible for a growth regulatory repressive transcriptional sub-signature of EWS-FLI1 in Ewing sarcoma.EWS/FLI utilizes NKX2-2 to repress mesenchymal features of Ewing sarcoma.The histone demethylase KDM3A, and its downstream target MCAM, promote Ewing Sarcoma cell migration and metastasis.Cell-to-cell heterogeneity of EWSR1-FLI1 activity determines proliferation/migration choices in Ewing sarcoma cells.Identification of Mithramycin Analogues with Improved Targeting of the EWS-FLI1 Transcription Factor EWS and RE1-Silencing Transcription Factor Inhibit Neuronal Phenotype Development and Oncogenic Transformation in Ewing Sarcoma Lysine-specific demethylase 1 (LSD1) destabilizes p62 and inhibits autophagy in gynecologic malignancies.Lurbinectedin Inactivates the Ewing Sarcoma Oncoprotein EWS-FLI1 by Redistributing It within the Nucleus.Identification of two types of GGAA-microsatellites and their roles in EWS/FLI binding and gene regulation in Ewing sarcoma.

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Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma.

http://www.wikidata.org/entity/Q39239580

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

@zh

2012年论文

@zh-cn

name

Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma.

@en

Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma.

@nl

type

label

Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma.

@en

Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma.

@nl

prefLabel

Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma.

@en

Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma.

@nl

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Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma.

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B Stephens

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R Bell

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R Zhuo

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S L Lessnick

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S Sankar

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S Sharma

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P2860

EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma

Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1

Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma

Oncogenic ETS proteins mimic activated RAS/MAPK signaling in prostate cells.

Oncogene mutation profiling of pediatric solid tumors reveals significant subsets of embryonal rhabdomyosarcoma and neuroblastoma with mutated genes in growth signaling pathways.

Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family

ETS transcription factors and their emerging roles in human cancer.

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42

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