Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers. - Wikidata - awgldk - TriplyDB

Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers.

Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers.

http://www.wikidata.org/entity/Q39424350

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The links between insulin resistance, diabetes, and cancer Interactions between tumor cells and microenvironment in breast cancer: a new opportunity for targeted therapy Metformin suppresses triple-negative breast cancer stem cells by targeting KLF5 for degradation.Herbal extract SH003 suppresses tumor growth and metastasis of MDA-MB-231 breast cancer cells by inhibiting STAT3-IL-6 signaling.Estrogen Receptor-β and the Insulin-Like Growth Factor Axis as Potential Therapeutic Targets for Triple-Negative Breast Cancer.Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention.Phenotypic switch in blood: effects of pro-inflammatory cytokines on breast cancer cell aggregation and adhesion Adult aortic valve interstitial cells have greater responses to toll-like receptor 4 stimulation.Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current Metformin inhibits the IL-6-induced epithelial-mesenchymal transition and lung adenocarcinoma growth and metastasis.In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors Metformin suppresses pancreatic tumor growth with inhibition of NFκB/STAT3 inflammatory signaling.The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts.Metformin Induces Apoptosis and Downregulates Pyruvate Kinase M2 in Breast Cancer Cells Only When Grown in Nutrient-Poor Conditions.Metformin selectively targets tumor-initiating cells in ErbB2-overexpressing breast cancer models.Transcriptomic analysis of pancreatic cancer cells in response to metformin and aspirin: an implication of synergy.Src/STAT3-dependent heme oxygenase-1 induction mediates chemoresistance of breast cancer cells to doxorubicin by promoting autophagy.Metformin-induced killing of triple-negative breast cancer cells is mediated by reduction in fatty acid synthase via miRNA-193b Metformin Treatment for the Prevention and/or Treatment of Breast/Mammary Tumorigenesis Morphoproteomics provides support for TGF-β pathway signaling in the osteoclastogenesis and immune dysregulation of osteolytic Langerhans cell histiocytosis.AMPK/mTOR-mediated inhibition of survivin partly contributes to metformin-induced apoptosis in human gastric cancer cell High Glucose-Mediated STAT3 Activation in Endometrial Cancer Is Inhibited by Metformin: Therapeutic Implications for Endometrial Cancer.Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2 Constitutive STAT3 phosphorylation contributes to skeletal muscle insulin resistance in type 2 diabetes.Tristetraprolin mediates the anti-proliferative effects of metformin in breast cancer cells Targeting HCCR expression resensitizes gastric cancer cells to chemotherapy via down-regulating the activation of STAT3.Interaction between p53 and estradiol pathways in transcriptional responses to chemotherapeutics.Metformin induces a senescence-associated gene signature in breast cancer cells.STAT signaling in different breast cancer sub-types.Disulfiram targets cancer stem-like cells and reverses resistance and cross-resistance in acquired paclitaxel-resistant triple-negative breast cancer cells.Curcumin improves the therapeutic efficacy of Listeria(at)-Mage-b vaccine in correlation with improved T-cell responses in blood of a triple-negative breast cancer model 4T1.Enhanced anti-tumor activity and cytotoxic effect on cancer stem cell population of metformin-butyrate compared with metformin HCl in breast cancer.Morphoproteomics and biomedical analytics confirm the mTORC2/Akt pathway as a resistance signature and activated ERK and STAT3 as concomitant prosurvival/antiapoptotic pathways in metastatic renal cell carcinoma (RCC) progressing on rapalogs: pathog Glucose promotes breast cancer aggression and reduces metformin efficacy.Metformin targets multiple signaling pathways in cancer.Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling.AMP-activated protein kinase and energy balance in breast cancer.Arctigenin inhibits STAT3 and exhibits anticancer potential in human triple-negative breast cancer therapy Genomic regulation of invasion by STAT3 in triple negative breast cancer.Metformin Suppresses Systemic Autoimmunity in Roquinsan/san Mice through Inhibiting B Cell Differentiation into Plasma Cells via Regulation of AMPK/mTOR/STAT3.

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Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers.

http://www.wikidata.org/entity/Q39424350

description

2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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2012年學術文章

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name

Metformin targets Stat3 to inh ...... riple-negative breast cancers.

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Metformin targets Stat3 to inh ...... riple-negative breast cancers.

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type

label

Metformin targets Stat3 to inh ...... riple-negative breast cancers.

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Metformin targets Stat3 to inh ...... riple-negative breast cancers.

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prefLabel

Metformin targets Stat3 to inh ...... riple-negative breast cancers.

@en

Metformin targets Stat3 to inh ...... riple-negative breast cancers.

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Anlong Deng

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Ann D Thor

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Bolin Liu

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Reema Wahdan-Alaswad

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Shuiliang Wang

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Stuart E Lind

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Susan M Edgerton

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Xin-Sheng Deng

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10.4161/CC.11.2.18813

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apoptotic process