C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes. - Wikidata - awgldk - TriplyDB

C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes.

C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes.

http://www.wikidata.org/entity/Q39440982

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Pathophysiology of osteoarthritis: canonical NF-κB/IKKβ-dependent and kinase-independent effects of IKKα in cartilage degradation and chondrocyte differentiation Insights on Molecular Mechanisms of Chondrocytes Death in Osteoarthritis Matrix metalloproteinases as therapeutic targets for idiopathic pulmonary fibrosis XBP1-Independent UPR Pathways Suppress C/EBP-β Mediated Chondrocyte Differentiation in ER-Stress Related Skeletal Disease Globularity and language-readiness: generating new predictions by expanding the set of genes of interest Suppression of discoidin domain receptor 1 expression enhances the chondrogenesis of adipose-derived stem cells.Prospective signs of cleidocranial dysplasia in Cebpb deficiency The RUNX2 cistrome in osteoblasts: characterization, down-regulation following differentiation, and relationship to gene expression.Deletion of Runx2 in Articular Chondrocytes Decelerates the Progression of DMM-Induced Osteoarthritis in Adult Mice.Signaling pathways in cartilage repair.CCAAT/enhancer binding protein β regulates expression of Indian hedgehog during chondrocytes differentiation.Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation.C/EBPβ mediates osteoclast recruitment by regulating endothelial progenitor cell expression of SDF-1α.Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2.Selective Distal Enhancer Control of the Mmp13 Gene Identified through Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) Genomic Deletions.Environmental disruption of circadian rhythm predisposes mice to osteoarthritis-like changes in knee joint.Emerging targets in osteoarthritis therapy.SOCS1 suppresses IL-1β-induced C/EBPβ expression via transcriptional regulation in human chondrocytes.Epigenetic and microRNA regulation during osteoarthritis development Chondrogenic commitment of human umbilical cord blood-derived mesenchymal stem cells in collagen matrices for cartilage engineering.MicroRNA-381 Regulates Chondrocyte Hypertrophy by Inhibiting Histone Deacetylase 4 Expression.iTRAQ-based proteomics reveals novel biomarkers of osteoarthritis.NFATc1 and NFATc2 repress spontaneous osteoarthritis.CCAAT/enhancer-binding protein β regulates the repression of type II collagen expression during the differentiation from proliferative to hypertrophic chondrocytes.Osteoarthritis: toward a comprehensive understanding of pathological mechanism.Insights from human genetic studies into the pathways involved in osteoarthritis.Chondrocyte hypertrophy in skeletal development, growth, and disease.Genome-wide DNA methylation study identifies significant epigenomic changes in osteoarthritic cartilage.E74-like factor 3 and nuclear factor-κB regulate lipocalin-2 expression in chondrocytes.Respiratory gases and the regulation of transcription.Runx2 and microRNA regulation in bone and cartilage diseases.Transcriptional Network Controlling Endochondral Ossification.Systematic identification of protein combinations mediating chromatin looping.Histone deacetylase inhibitor vorinostat (SAHA, MK0683) perturb miR-9-MCPIP1 axis to block IL-1β-induced IL-6 expression in human OA chondrocytes.Inhibition of vascular endothelial growth factor with shRNA in chondrocytes ameliorates osteoarthritis.Tackling chondrocyte hypertrophy with multifunctional nanoparticles.DNA methylation of the RUNX2 P1 promoter mediates MMP13 transcription in chondrocytes.Regulation of Cartilage Development and Diseases by Transcription Factors.RUNX2 RNA interference inhibits the invasion of osteosarcoma.Hydrostatic pressure influences HIF-2 alpha expression in chondrocytes.

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C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes.

http://www.wikidata.org/entity/Q39440982

description

2011 nî lūn-bûn

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C/EBPβ and RUNX2 cooperate to ...... s the inducer in chondrocytes.

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C/EBPβ and RUNX2 cooperate to ...... s the inducer in chondrocytes.

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Human Molecular Genetics

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C/EBPβ and RUNX2 cooperate to ...... s the inducer in chondrocytes.

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Akihiko Mabuchi

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Atsushi Fukai

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Bishwa Raj Sapkota

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Fumiko Yano

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Fumitaka Kugimiya

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Hiroshi Kawaguchi

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Katsushi Tokunaga

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Kozo Nakamura

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Makoto Hirata

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Nao Nishida

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P2860

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

Maturational disturbance of chondrocytes in Cbfa1-deficient mice

Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

Radiological assessment of osteo-arthrosis

Developmental regulation of the growth plate

New experimental approaches in retrovirus-mediated expression screening.

C/EBPbeta Promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p57.

Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development.

GADD45beta enhances Col10a1 transcription via the MTK1/MKK3/6/p38 axis and activation of C/EBPbeta-TAD4 in terminally differentiating chondrocytes

Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis.

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1111-1123

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10.1093/HMG/DDR540

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5

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21

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2011-11-17T00:00:00Z

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51807886

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22095691

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