Sequential regulation of the small GTPase Rap1 in human platelets. - Wikidata - awgldk - TriplyDB

Sequential regulation of the small GTPase Rap1 in human platelets.

Sequential regulation of the small GTPase Rap1 in human platelets.

http://www.wikidata.org/entity/Q39450674

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WNT-3a modulates platelet function by regulating small GTPase activity Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred.Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling.RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences The small GTPase Rap1b regulates the cross talk between platelet integrin alpha2beta1 and integrin alphaIIbbeta3 Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation High glucose stimulates synthesis of fibronectin via a novel protein kinase C, Rap1b, and B-Raf signaling pathway Vasodilator-Stimulated Phosphoprotein (VASP)-dependent and -independent pathways regulate thrombin-induced activation of Rap1b in platelets RASA3 is a critical inhibitor of RAP1-dependent platelet activation Slowed decay of mRNAs enhances platelet specific translation Rap1b is required for normal platelet function and hemostasis in mice Thrombopoietin-mediated sustained activation of extracellular signal-regulated kinase in UT7-Mpl cells requires both Ras-Raf-1- and Rap1-B-Raf-dependent pathways The small GTPase Rap1 is activated by turbulence and is involved in integrin [alpha]IIb[beta]3-mediated cell adhesion in human megakaryocytes.Contribution of protease-activated receptors 1 and 4 and glycoprotein Ib-IX-V in the G(i)-independent activation of platelet Rap1B by thrombin.PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation.Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase.Rap1 promotes endothelial mechanosensing complex formation, NO release and normal endothelial function.Distinct roles for Rap1b protein in platelet secretion and integrin αIIbβ3 outside-in signaling Rap1b regulates B cell development, homing, and T cell-dependent humoral immunity.RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome.Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling.CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets.UV-C irradiation disrupts platelet surface disulfide bonds and activates the platelet integrin alphaIIbbeta3.RAP1-GTPase signaling and platelet function.Cyclic AMP-mediated inhibition of cell growth requires the small G protein Rap1.The high-risk human papillomavirus type 16 E6 counters the GAP function of E6TP1 toward small Rap G proteins.A Wnt-CKIvarepsilon-Rap1 pathway regulates gastrulation by modulating SIPA1L1, a Rap GTPase activating protein.Rap1 is activated by erythropoietin or interleukin-3 and is involved in regulation of beta1 integrin-mediated hematopoietic cell adhesion.Rap1A regulates generation of T regulatory cells via LFA-1-dependent and LFA-1-independent mechanisms.Rap1b is critical for glycoprotein VI-mediated but not ADP receptor-mediated alpha2beta1 activation.Irreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosphatidylinositol phosphates.Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton.EphB2 regulates contact-dependent and contact-independent signaling to control platelet function.A Gi-dependent pathway is required for activation of the small GTPase Rap1B in human platelets.Activation of Rap1B by G(i) family members in platelets.F-actin-dependent translocation of the Rap1 GDP/GTP exchange factor RasGRP2.Functional links between Disabled-2 Ser723 phosphorylation and thrombin signaling in human platelets.C3G promotes a selective release of angiogenic factors from activated mouse platelets to regulate angiogenesis and tumor metastasis.

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P2860

Sequential regulation of the small GTPase Rap1 in human platelets.

http://www.wikidata.org/entity/Q39450674

description

2000 nî lūn-bûn

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2000年の論文

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2000年学术文章

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2000年学术文章

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2000年学术文章

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2000年学术文章

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2000年学术文章

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2000年學術文章

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2000年學術文章

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2000年學術文章

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name

Sequential regulation of the small GTPase Rap1 in human platelets.

@en

Sequential regulation of the small GTPase Rap1 in human platelets.

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type

label

Sequential regulation of the small GTPase Rap1 in human platelets.

@en

Sequential regulation of the small GTPase Rap1 in human platelets.

@nl

prefLabel

Sequential regulation of the small GTPase Rap1 in human platelets.

@en

Sequential regulation of the small GTPase Rap1 in human platelets.

@nl

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MCB.20.3.779-785.2000

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Molecular and Cellular Biology

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Sequential regulation of the small GTPase Rap1 in human platelets.

@en

P2093

B Franke

http://www.w3.org/2001/XMLSchema#string

C Negrier

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G van Willigen

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H K Nieuwenhuis

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J L Bos

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J W Akkerman

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K M de Bruijn

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M van Triest

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P2860

A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

A family of cAMP-binding proteins that directly activate Rap1

Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion

A ras-related gene with transformation suppressor activity

Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G

BUD2 encodes a GTPase-activating protein for Bud1/Rsr1 necessary for proper bud-site selection in yeast.

A yeast gene (BEM1) necessary for cell polarization whose product contains two SH3 domains

Role of Crk oncogene product in physiologic signaling.

Two active states of the Ras-related Bud1/Rsr1 protein bind to different effectors to determine yeast cell polarity.

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