Sequential regulation of the small GTPase Rap1 in human platelets.
about
WNT-3a modulates platelet function by regulating small GTPase activityInteractions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred.Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling.RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequencesThe small GTPase Rap1b regulates the cross talk between platelet integrin alpha2beta1 and integrin alphaIIbbeta3Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functionsCalDAG-GEFI integrates signaling for platelet aggregation and thrombus formationHigh glucose stimulates synthesis of fibronectin via a novel protein kinase C, Rap1b, and B-Raf signaling pathwayVasodilator-Stimulated Phosphoprotein (VASP)-dependent and -independent pathways regulate thrombin-induced activation of Rap1b in plateletsRASA3 is a critical inhibitor of RAP1-dependent platelet activationSlowed decay of mRNAs enhances platelet specific translationRap1b is required for normal platelet function and hemostasis in miceThrombopoietin-mediated sustained activation of extracellular signal-regulated kinase in UT7-Mpl cells requires both Ras-Raf-1- and Rap1-B-Raf-dependent pathwaysThe small GTPase Rap1 is activated by turbulence and is involved in integrin [alpha]IIb[beta]3-mediated cell adhesion in human megakaryocytes.Contribution of protease-activated receptors 1 and 4 and glycoprotein Ib-IX-V in the G(i)-independent activation of platelet Rap1B by thrombin.PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation.Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase.Rap1 promotes endothelial mechanosensing complex formation, NO release and normal endothelial function.Distinct roles for Rap1b protein in platelet secretion and integrin αIIbβ3 outside-in signalingRap1b regulates B cell development, homing, and T cell-dependent humoral immunity.RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome.Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling.CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets.UV-C irradiation disrupts platelet surface disulfide bonds and activates the platelet integrin alphaIIbbeta3.RAP1-GTPase signaling and platelet function.Cyclic AMP-mediated inhibition of cell growth requires the small G protein Rap1.The high-risk human papillomavirus type 16 E6 counters the GAP function of E6TP1 toward small Rap G proteins.A Wnt-CKIvarepsilon-Rap1 pathway regulates gastrulation by modulating SIPA1L1, a Rap GTPase activating protein.Rap1 is activated by erythropoietin or interleukin-3 and is involved in regulation of beta1 integrin-mediated hematopoietic cell adhesion.Rap1A regulates generation of T regulatory cells via LFA-1-dependent and LFA-1-independent mechanisms.Rap1b is critical for glycoprotein VI-mediated but not ADP receptor-mediated alpha2beta1 activation.Irreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosphatidylinositol phosphates.Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton.EphB2 regulates contact-dependent and contact-independent signaling to control platelet function.A Gi-dependent pathway is required for activation of the small GTPase Rap1B in human platelets.Activation of Rap1B by G(i) family members in platelets.F-actin-dependent translocation of the Rap1 GDP/GTP exchange factor RasGRP2.Functional links between Disabled-2 Ser723 phosphorylation and thrombin signaling in human platelets.C3G promotes a selective release of angiogenic factors from activated mouse platelets to regulate angiogenesis and tumor metastasis.
P2860
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P2860
Sequential regulation of the small GTPase Rap1 in human platelets.
description
2000 nî lūn-bûn
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2000年の論文
@ja
2000年学术文章
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2000年学术文章
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2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
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2000年學術文章
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2000年學術文章
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name
Sequential regulation of the small GTPase Rap1 in human platelets.
@en
Sequential regulation of the small GTPase Rap1 in human platelets.
@nl
type
label
Sequential regulation of the small GTPase Rap1 in human platelets.
@en
Sequential regulation of the small GTPase Rap1 in human platelets.
@nl
prefLabel
Sequential regulation of the small GTPase Rap1 in human platelets.
@en
Sequential regulation of the small GTPase Rap1 in human platelets.
@nl
P2093
P2860
P1476
Sequential regulation of the small GTPase Rap1 in human platelets.
@en
P2093
G van Willigen
H K Nieuwenhuis
J W Akkerman
K M de Bruijn
M van Triest
P2860
P304
P356
10.1128/MCB.20.3.779-785.2000
P407
P577
2000-02-01T00:00:00Z