Engineering the specificity of antibacterial fluoroquinolones: benzenesulfonamide modifications at C-7 of ciprofloxacin change its primary target in Streptococcus pneumoniae from topoisomerase IV to gyrase.
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Emerging mechanisms of fluoroquinolone resistanceMycobacterium tuberculosis DNA gyrase: interaction with quinolones and correlation with antimycobacterial drug activityNew mutation in parE in a pneumococcal in vitro mutant resistant to fluoroquinolones.Novelties in the field of anti-infective compounds in 1999.Accumulation of mutations in both gyrB and parE genes is associated with high-level resistance to novobiocin in Staphylococcus aureus.Prulifloxacin: a new antibacterial fluoroquinolone.Topoisomerase targeting with and resistance to gemifloxacin in Staphylococcus aureusTherapeutic potential of the new quinolones in the treatment of lower respiratory tract infections.Gemifloxacin: a new fluoroquinolone.Synthesis and potential antitumor activity of 7-(4-substituted piperazin-1-yl)-4-oxoquinolines based on ciprofloxacin and norfloxacin scaffolds: in silico studies.Contributions of the 8-methoxy group of gatifloxacin to resistance selectivity, target preference, and antibacterial activity against Streptococcus pneumoniae.Selection and genetic characterization of Streptococcus pneumoniae mutants resistant to the des-F(6) quinolone BMS-284756.Quinolone resistance mutations in Streptococcus pneumoniae GyrA and ParC proteins: mechanistic insights into quinolone action from enzymatic analysis, intracellular levels, and phenotypes of wild-type and mutant proteins.Potent antipneumococcal activity of gemifloxacin is associated with dual targeting of gyrase and topoisomerase IV, an in vivo target preference for gyrase, and enhanced stabilization of cleavable complexes in vitro.Grepafloxacin, a dimethyl derivative of ciprofloxacin, acts preferentially through gyrase in Streptococcus pneumoniae: role of the C-5 group in target specificity.Small-colony mutants of Staphylococcus aureus allow selection of gyrase-mediated resistance to dual-target fluoroquinolones.In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus.Ciprofloxacin dimers target gyrase in Streptococcus pneumoniae.Mechanism of action of the antibiotic NXL101, a novel nonfluoroquinolone inhibitor of bacterial type II topoisomerases.Probing the differential interactions of quinazolinedione PD 0305970 and quinolones with gyrase and topoisomerase IV
P2860
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P2860
Engineering the specificity of antibacterial fluoroquinolones: benzenesulfonamide modifications at C-7 of ciprofloxacin change its primary target in Streptococcus pneumoniae from topoisomerase IV to gyrase.
description
2000 nî lūn-bûn
@nan
2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
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name
Engineering the specificity of ...... om topoisomerase IV to gyrase.
@en
Engineering the specificity of ...... om topoisomerase IV to gyrase.
@nl
type
label
Engineering the specificity of ...... om topoisomerase IV to gyrase.
@en
Engineering the specificity of ...... om topoisomerase IV to gyrase.
@nl
prefLabel
Engineering the specificity of ...... om topoisomerase IV to gyrase.
@en
Engineering the specificity of ...... om topoisomerase IV to gyrase.
@nl
P2093
P2860
P1476
Engineering the specificity of ...... om topoisomerase IV to gyrase.
@en
P2093
P2860
P304
P356
10.1128/AAC.44.2.320-325.2000
P407
P577
2000-02-01T00:00:00Z