Allosteric regulation of the epidermal growth factor receptor kinase
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The Croonian Lecture 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and diseaseAggregation of complement receptors on human neutrophils in the absence of ligandComputational modeling reveals molecular details of epidermal growth factor bindingCooperative roles of SDF-1α and EGF gradients on tumor cell migration revealed by a robust 3D microfluidic modelStructural Basis for Negative Cooperativity in Growth Factor Binding to an EGF ReceptorFiz1, a novel zinc finger protein interacting with the receptor tyrosine kinase Flt3Expression of the epidermal growth factor receptor gene is regulated in mouse blastocysts during delayed implantationHotspot mutations in KIT receptor differentially modulate its allosterically coupled conformational dynamics: impact on activation and drug sensitivityTyrosine kinase activity is essential for the association of phospholipase C-gamma with the epidermal growth factor receptorProtein kinase C activity in rat skeletal muscle. Apparent relation to body weight and muscle growth.Phosphorylation and activation of epidermal growth factor receptors in cells transformed by the src oncogeneThe role of endogenous epidermal growth factor receptor ligands in mediating corneal epithelial homeostasis.Continuous monitoring of receptor-mediated changes in the metabolic rates of living cells.Ligand-induced stimulation of epidermal growth factor receptor mutants with altered transmembrane regionsPhosphorylation at threonine-654 is not required for negative regulation of the epidermal growth factor receptor by non-phorbol tumor promoters.Evidence that autophosphorylation of solubilized receptors for epidermal growth factor is mediated by intermolecular cross-phosphorylationExperimental approaches to hypothetical hormones: detection of a candidate ligand of the neu protooncogene.Inhibition of human tumor growth in nude mice by a conjugate of doxorubicin with monoclonal antibodies to epidermal growth factor receptorExogenous ATP and other nucleoside phosphates modulate epidermal growth factor receptors of A-431 epidermoid carcinoma cells.Mechanisms of activation of receptor tyrosine kinases: monomers or dimers.Heterogeneity of epidermal growth factor binding kinetics on individual cells.From wavy hair to naked proteins: the role of transforming growth factor alpha in health and disease.An insertional mutant of epidermal growth factor receptor allows dissection of diverse receptor functionsConfined lateral diffusion of membrane receptors as studied by single particle tracking (nanovid microscopy). Effects of calcium-induced differentiation in cultured epithelial cells.Molecular dynamics of alamethicin transmembrane channels from open-channel current noise analysis.Single particle tracking. Analysis of diffusion and flow in two-dimensional systemsImplications of epidermal growth factor (EGF) induced egf receptor aggregationAlterations of human placental epidermal growth factor receptor in intrauterine growth retardationMechanism of epidermal growth factor receptor autophosphorylation and high-affinity bindingRecruitment of epidermal growth factor and transferrin receptors into coated pits in vitro: differing biochemical requirements.Evidence for glomerular actions of epidermal growth factor in the ratSynergistic effects of bombesin and epidermal growth factor on cancers.A structure-based model for ligand binding and dimerization of EGF receptors.Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membraneGenetics of dark skin in mice.EGF-stimulated tyrosine phosphorylation of p185neu: a potential model for receptor interactions.Overexpression of epidermal growth factor receptor in NIH-3T3-transfected cells slows its lateral diffusion and rate of endocytosis.A431 cell variants lacking the blood group A antigen display increased high affinity epidermal growth factor-receptor number, protein-tyrosine kinase activity, and receptor turnover.Iterative fractionation of recycling receptors from lysosomally destined ligands in an early sorting endosome.High-affinity epidermal growth factor binding is specifically reduced by a monoclonal antibody, and appears necessary for early responses.
P2860
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P2860
Allosteric regulation of the epidermal growth factor receptor kinase
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年学术文章
@wuu
1986年学术文章
@zh-cn
1986年学术文章
@zh-hans
1986年学术文章
@zh-my
1986年学术文章
@zh-sg
1986年學術文章
@yue
1986年學術文章
@zh
1986年學術文章
@zh-hant
name
Allosteric regulation of the epidermal growth factor receptor kinase
@en
Allosteric regulation of the epidermal growth factor receptor kinase.
@nl
type
label
Allosteric regulation of the epidermal growth factor receptor kinase
@en
Allosteric regulation of the epidermal growth factor receptor kinase.
@nl
prefLabel
Allosteric regulation of the epidermal growth factor receptor kinase
@en
Allosteric regulation of the epidermal growth factor receptor kinase.
@nl
P2860
P921
P356
P1476
Allosteric regulation of the epidermal growth factor receptor kinase
@en
P2093
Schlessinger J
P2860
P304
P356
10.1083/JCB.103.6.2067
P407
P433
P577
1986-12-01T00:00:00Z