Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice. - Wikidata - awgldk - TriplyDB

Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice.

Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice.

http://www.wikidata.org/entity/Q39508679

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Fucoxanthin and Its Metabolite Fucoxanthinol in Cancer Prevention and Treatment Bile Acid Metabolism and Signaling in Cholestasis, Inflammation, and Cancer Role of pregnane X receptor in chemotherapeutic treatment Pregnane X receptor as a target for treatment of inflammatory bowel disorders Targeting xenobiotic receptors PXR and CAR in human diseases PXR variants: the impact on drug metabolism and therapeutic responses Bile acid signaling in metabolic disease and drug therapy Alleviation of gut inflammation by Cdx2/Pxr pathway in a mouse model of chemical colitis Role of PXR in Hepatic Cancer: Its Influences on Liver Detoxification Capacity and Cancer Progression Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4.Bisphenol A increases atherosclerosis in pregnane X receptor-humanized ApoE deficient mice.Tissue-specific regulation of pregnane X receptor in cancer development and therapy.Activation of intestinal human pregnane X receptor protects against azoxymethane/dextran sulfate sodium-induced colon cancer Intestinal pregnane X receptor links xenobiotic exposure and hypercholesterolemia.Reporter Cell Lines for the Characterization of the Interactions between Human Nuclear Receptors and Endocrine Disruptors.Fucoxanthin attenuates rifampin-induced cytochrome P450 3A4 (CYP3A4) and multiple drug resistance 1 (MDR1) gene expression through pregnane X receptor (PXR)-mediated pathways in human hepatoma HepG2 and colon adenocarcinoma LS174T cells.Bisphenol A and its analogues activate human pregnane X receptor Serine 350 of human pregnane X receptor is crucial for its heterodimerization with retinoid X receptor alpha and transactivation of target genes in vitro and in vivo Sesamin: A Naturally Occurring Lignan Inhibits CYP3A4 by Antagonizing the Pregnane X Receptor Activation.Pregnane X Receptor Represses HNF4α Gene to Induce Insulin-Like Growth Factor-Binding Protein IGFBP1 that Alters Morphology of and Migrates HepG2 Cells.St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling.RBCK1, an E3 ubiquitin ligase, interacts with and ubiquinates the human pregnane X receptor.PXR antagonists and implication in drug metabolism.Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis.Expression of the PXR gene in various types of cancer and drug resistance Tumor suppressor protein p53 negatively regulates human pregnane X receptor activity.PXR interaction with p53: a meeting of two masters Human pregnane X receptor compromises the function of p53 and promotes malignant transformation Pregnane X Receptor and Cancer: Context-Specificity is Key.Metformin represses drug-induced expression of CYP2B6 by modulating the constitutive androstane receptor signaling.Fibroblast growth factor receptor 4 (FGFR4) and fibroblast growth factor 19 (FGF19) autocrine enhance breast cancer cells survival.Pregnane X-receptor promotes stem cell-mediated colon cancer relapse Emerging role of fibroblast growth factors 15/19 and 21 as metabolic integrators in the liver.Pregnane xenobiotic receptor in cancer pathogenesis and therapeutic response.Nuclear receptors in bile acid metabolism Effect of pregnane X receptor expression on drug resistance in breast cancer.Regulation of PXR and CAR by protein-protein interaction and signaling crosstalk.Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity.Minor role of pregnane-x-receptor for acquired multidrug resistance in head and neck squamous cell carcinoma in vitro.Expression of NR1I3 in mouse lung tumors induced by the tobacco-specific nitrosamine 4-(methylnitrosamino)-4-(3-pyridyl)-1-butanone.

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P2860

Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice.

http://www.wikidata.org/entity/Q39508679

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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2011年论文

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2011年论文

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name

Pregnane X receptor activation ...... essiveness in humans and mice.

@en

Pregnane X receptor activation ...... essiveness in humans and mice.

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type

label

Pregnane X receptor activation ...... essiveness in humans and mice.

@en

Pregnane X receptor activation ...... essiveness in humans and mice.

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prefLabel

Pregnane X receptor activation ...... essiveness in humans and mice.

@en

Pregnane X receptor activation ...... essiveness in humans and mice.

@nl

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P1433

Journal of Clinical Investigation

P1476

Pregnane X receptor activation ...... essiveness in humans and mice.

@en

P2093

Andreas Kaubisch

http://www.w3.org/2001/XMLSchema#string

Andres I Roig

http://www.w3.org/2001/XMLSchema#string

Arunima Biswas

http://www.w3.org/2001/XMLSchema#string

Hao Li

http://www.w3.org/2001/XMLSchema#string

Hongwei Wang

http://www.w3.org/2001/XMLSchema#string

James Pullman

http://www.w3.org/2001/XMLSchema#string

Jerry W Shay

http://www.w3.org/2001/XMLSchema#string

Kathleen Whitney

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Lei Wang

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Liang Zhu

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P2860

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

Src phosphorylation of the epidermal growth factor receptor at novel sites mediates receptor interaction with Src and P85 alpha

Bisphenol A and estradiol are equipotent in antagonizing cisplatin-induced cytotoxicity in breast cancer cells

Endocrine-disrupting chemicals: an Endocrine Society scientific statement

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

Structural insights into the promiscuity and function of the human pregnane X receptor

The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

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3220-3232

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10.1172/JCI41514

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8

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121

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Moosa Mohammadi

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2011-07-11T00:00:00Z

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21747170

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3148718

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