Structural insights into the promiscuity and function of the human pregnane X receptor
about
sameAs
Neurosteroid regulation of central nervous system developmentEvolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile saltsActive nuclear receptors exhibit highly correlated AF-2 domain motionsThe phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptorHybrid scoring and classification approaches to predict human pregnane X receptor activatorsActivation of xenobiotic receptors: driving into the nucleus.Understanding nuclear receptors using computational methods.Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists.Treatment of cardiovascular disease by traditional Chinese medicine against pregnane X receptorOvercoming drug resistance by regulating nuclear receptors.Thiazide-like diuretic drug metolazone activates human pregnane X receptor to induce cytochrome 3A4 and multidrug-resistance protein 1.Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicitiesIdentification of STAT3-independent regulatory effects for protein inhibitor of activated STAT3 by binding to novel transcription factors.Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters.CAR and PXR: the xenobiotic-sensing receptors.Functional evolution of the pregnane X receptor.Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds.PXR antagonists and implication in drug metabolism.Machine learning methods and docking for predicting human pregnane X receptor activation.Structural basis of human pregnane X receptor activation by the hops constituent colupuloneThe structural basis of pregnane X receptor binding promiscuity.Orphan nuclear receptors as targets for drug development.Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice.Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation.Comparative In Vitro and In Silico Analysis of the Selectivity of Indirubin as a Human Ah Receptor Agonist
P2860
Q24653847-6A11202A-8EED-409E-8014-7E98EBFCF4DEQ28755660-BCABEEB1-4825-4F2E-977E-FAE9BD27AEE9Q30845026-528ED9B1-4882-4557-9C2D-700F57F30B57Q33642959-1DB6E54A-2A28-43FE-8CCC-E934FC9D7D75Q33720954-332B942B-35C7-4644-B060-F901974395CAQ33742134-33322C14-04DB-4EED-AFC0-77102BA07838Q33755918-A2AF0339-AD71-4056-9471-CCE839B53ECAQ33756500-FAB793B4-799D-4052-BCE9-827CE257F563Q33876600-44E8C1FF-E9A1-46B4-B4DE-AFBFE1E2B7C2Q34349313-36FDD62A-D4EC-4188-94D9-594A0181FA53Q34614106-1D79E9A8-4029-4886-B2C8-63256E3C77F7Q34625038-7C2F3167-60CA-499E-A574-7BB9C3055DB0Q35158714-42E106C5-6E03-4616-BE4F-05CA31B3D77CQ35919726-542C26E7-DE92-48CD-8B7E-4A83488896B5Q35944704-B23E62DC-49CE-4E24-BF90-93D470B72591Q36440155-E14EE8AA-77DE-47FC-8936-E1F121599414Q36440873-46282D97-7AF4-440E-8608-25A9A594D8D9Q36640752-AFB38953-2D4F-447E-92A0-646BCBFB622BQ36951921-A66E63E1-EBA3-4E7C-B958-972E73AF7C89Q36976887-701B1646-31E1-40F8-BD27-B4F03D811A47Q37461507-71BE8996-DE0D-4AA6-9B3B-BC7E29831065Q37725708-2AB6A602-6154-464A-AA0E-25AA02AED2A1Q39508679-79D9FA03-E6EA-4CBA-8380-E79EFB74BE35Q39578562-09984218-32C2-43A5-AFA6-6A91154483A8Q58753083-99EF99F2-9EFE-419C-853D-71AB2133B0EA
P2860
Structural insights into the promiscuity and function of the human pregnane X receptor
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Structural insights into the promiscuity and function of the human pregnane X receptor
@ast
Structural insights into the promiscuity and function of the human pregnane X receptor
@en
Structural insights into the promiscuity and function of the human pregnane X receptor
@nl
type
label
Structural insights into the promiscuity and function of the human pregnane X receptor
@ast
Structural insights into the promiscuity and function of the human pregnane X receptor
@en
Structural insights into the promiscuity and function of the human pregnane X receptor
@nl
prefLabel
Structural insights into the promiscuity and function of the human pregnane X receptor
@ast
Structural insights into the promiscuity and function of the human pregnane X receptor
@en
Structural insights into the promiscuity and function of the human pregnane X receptor
@nl
P1476
Structural insights into the promiscuity and function of the human pregnane X receptor
@en
P2093
Ryan E Watkins
Schroeder M Noble
P304
P407
P577
2002-01-01T00:00:00Z