Failure of origin activation in response to fork stalling leads to chromosomal instability at fragile sites.
about
Common fragile sites: genomic hotspots of DNA damage and carcinogenesisLeukemogenic rearrangements at the mixed lineage leukemia gene (MLL)-multiple rather than a single mechanismDNA secondary structure at chromosomal fragile sites in human disease.A concomitant loss of dormant origins and FANCC exacerbates genome instability by impairing DNA replication fork progression.CtIP maintains stability at common fragile sites and inverted repeats by end resection-independent endonuclease activity.Cancer chromosomal instability: therapeutic and diagnostic challenges.De novo CNV formation in mouse embryonic stem cells occurs in the absence of Xrcc4-dependent nonhomologous end joining.Recombination and replication.Recovery of arrested replication forks by homologous recombination is error-prone.Are common fragile sites merely structural domains or highly organized "functional" units susceptible to oncogenic stress?Rescue from replication stress during mitosis.DNA double-strand breaks coupled with PARP1 and HNRNPA2B1 binding sites flank coordinately expressed domains in human chromosomesFragile site instability in Saccharomyces cerevisiae causes loss of heterozygosity by mitotic crossovers and break-induced replication.Large transcription units unify copy number variants and common fragile sites arising under replication stressBreak-seq reveals hydroxyurea-induced chromosome fragility as a result of unscheduled conflict between DNA replication and transcriptionCyclin E deregulation promotes loss of specific genomic regions.Rescue of replication failure by Fanconi anaemia proteins.Chromatin changes in the development and pathology of the Fragile X-associated disorders and Friedreich ataxia.A genome-wide analysis of common fragile sites: what features determine chromosomal instability in the human genome?Evidence for chromosome fragility at the frataxin locus in Friedreich ataxia.Mechanism of replicative DNA polymerase delta pausing and a potential role for DNA polymerase kappa in common fragile site replication.The presence of extra chromosomes leads to genomic instability.A TRF1-controlled common fragile site containing interstitial telomeric sequences.Role of DNA secondary structures in fragile site breakage along human chromosome 10Identification of early replicating fragile sites that contribute to genome instabilityDNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis.Replication stress induces specific enrichment of RECQ1 at common fragile sites FRA3B and FRA16DSister chromatid telomere fusions, but not NHEJ-mediated inter-chromosomal telomere fusions, occur independently of DNA ligases 3 and 4.The BLM dissolvasome in DNA replication and repair.Methylation of histone H4 lysine 20 by PR-Set7 ensures the integrity of late replicating sequence domains in DrosophilaCyclin Kinase-independent role of p21CDKN1A in the promotion of nascent DNA elongation in unstressed cells.On the opportunistic nature of transcription and replication initiation in the metazoan genome.Replication fork dynamics and the DNA damage response.Dormant origins, the licensing checkpoint, and the response to replicative stressesImpediments to replication fork movement: stabilisation, reactivation and genome instability.Molecular characterization of common fragile sites as a strategy to discover cancer susceptibility genes.Updating the mechanisms of common fragile site instability: how to reconcile the different views?Interplay between genetic and epigenetic factors governs common fragile site instability in cancer.Structural genomic alterations in primary mediastinal large B-cell lymphoma.A journey through the microscopic ages of DNA replication.
P2860
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P2860
Failure of origin activation in response to fork stalling leads to chromosomal instability at fragile sites.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Failure of origin activation i ...... instability at fragile sites.
@en
Failure of origin activation i ...... instability at fragile sites.
@nl
type
label
Failure of origin activation i ...... instability at fragile sites.
@en
Failure of origin activation i ...... instability at fragile sites.
@nl
prefLabel
Failure of origin activation i ...... instability at fragile sites.
@en
Failure of origin activation i ...... instability at fragile sites.
@nl
P2093
P1433
P1476
Failure of origin activation i ...... instability at fragile sites.
@en
P2093
Aaron Bensimon
Assaf C Bester
Ayelet Rahat
Batsheva Kerem
Efrat Ozeri-Galai
Ronald Lebofsky
P304
P356
10.1016/J.MOLCEL.2011.05.019
P577
2011-07-01T00:00:00Z